Lentivirus-mediated gene transfer of viral interleukin-10 delays but does not prevent cardiac allograft rejection

Human immunodeficiency virus (HIV)-based lentiviral vectors expressing viral interleukin-10 (vIL-10) were used to transduce rat cardiac allografts with the aim of extending graft survival. vIL-10 expression was first shown, by RT-PCR, to persist in transduced heart isografts for at least 28 days aft...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Gene therapy 2005-10, Vol.12 (20), p.1509-1516
Hauptverfasser:	Zhao, J, Pettigrew, G J, Bolton, E M, Murfitt, C R, Carmichael, A, Bradley, J A, Lever, A M L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloantigens Allografts Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Aorta Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Care and treatment Cell Biology Cell growth Cell proliferation Cyclosporine - therapeutic use Cytokines Dosage and administration Endothelial cells Expression vectors Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genetic aspects Genetic Therapy - methods Genetic transformation Genetic Vectors - administration & dosage Graft rejection Graft Rejection - immunology Graft Rejection - therapy Health. Pharmaceutical industry Heart transplantation Heart Transplantation - immunology HIV HIV - genetics Human Genetics Human immunodeficiency virus Immunosuppressive Agents - therapeutic use Industrial applications and implications. Economical aspects Interleukin 10 Interleukin-10 - analysis Interleukin-10 - genetics Lentivirus Lymphocyte Activation Lymphocytes - immunology Lymphocytes T Male Medical sciences Nanotechnology Physiological aspects Polymerase chain reaction Rats Rats, Inbred Lew Rats, Sprague-Dawley research-article Syngeneic grafts Thymidine Transduction, Genetic - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation, Homologous Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!