Further evidence that hyperhomocysteinemia and methylenetetrahydrofolate reductase C677T and A1289C polymorphisms are not risk factors for schizophrenia
It has been suggested that total plasma homocysteine (tHcy) concentrations and methylenetetrahydrofolate reductase ( MTHFR) gene polymorphisms are risk factors for schizophrenia. We conducted a case-control study to investigate whether tHcy levels and MTHFR C677T and A1298C variants are associated w...
Gespeichert in:
| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2005-09, Vol.29 (7), p.1169-1174 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1174 |
|---|---|
| container_issue | 7 |
| container_start_page | 1169 |
| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
| container_volume | 29 |
| creator | Vilella, Elisabet Virgos, Carmen Murphy, Michelle Martorell, Lourdes Valero, Joaquín Simó, Josep Maria Joven, Jorge Fernández-Ballart, Joan Labad, Antonio |
| description | It has been suggested that total plasma homocysteine (tHcy) concentrations and methylenetetrahydrofolate reductase (
MTHFR) gene polymorphisms are risk factors for schizophrenia. We conducted a case-control study to investigate whether tHcy levels and
MTHFR C677T and A1298C variants are associated with schizophrenia, giving special consideration to confounding factors. Logistic regression analysis showed that neither tHcy nor
MTHFR polymorphisms were associated with schizophrenia. Homozygosity for
MTHFR C677T was associated with higher tHcy concentrations in control and schizophrenia groups (
P
<
0.01), which was mainly driven by the male group. The A1298C variant did not show any association with tHcy concentrations. In conclusion, these results do not confirm an independent relationship of tHcy and
MTHFR genotype with risk of schizophrenia. |
| doi_str_mv | 10.1016/j.pnpbp.2005.07.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68652433</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0278584605002241</els_id><sourcerecordid>68652433</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-2a0ff8b05ac52b31a63f1efe4213b464216b417af8a22e59a4f2096308753e1c3</originalsourceid><addsrcrecordid>eNp9kb-O1DAQhy0E4paFJ0BCrug2-E9iZwuK0-oOkE6iOWrLccaKlyQOY-ek8CQ8LsntSnRUM8U3M5rfR8h7zgrOuPp0LqZxaqZCMFYVTBeM8Rdkx2tdH0rB1UuyY2Ltq7pUN-RNSme2EpLJ1-SGK6ZVxfWO_LmfMXeAFJ5CC6MDmjubabdMgF0coltShjDCECy1Y0sHyN3SwwgZMtpuaTH62NsMFKGdXbYJ6Elp_fhM33JRH090iv0yRJy6kIZELQIdY6YY0k_qrcsRE_URaXJd-B2nDmEM9i155W2f4N217smP-7vH09fDw_cv3063DwcnK50PwjLv64ZV1lWikdwq6Tl4WBOQTam2IJqSa-trKwRUR1t6wY5KslpXEriTe_LxsnfC-GuGlM0QkoO-tyPEORlVq0qUUq6gvIAOY0oI3kwYBouL4cxsQszZPAsxmxDDtNni3pMP1_VzM0D7b-ZqYAU-XwBYn3wKgCa5sIloA4LLpo3hvwf-AuBQoJg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68652433</pqid></control><display><type>article</type><title>Further evidence that hyperhomocysteinemia and methylenetetrahydrofolate reductase C677T and A1289C polymorphisms are not risk factors for schizophrenia</title><source>ScienceDirect</source><source>MEDLINE</source><creator>Vilella, Elisabet ; Virgos, Carmen ; Murphy, Michelle ; Martorell, Lourdes ; Valero, Joaquín ; Simó, Josep Maria ; Joven, Jorge ; Fernández-Ballart, Joan ; Labad, Antonio</creator><creatorcontrib>Vilella, Elisabet ; Virgos, Carmen ; Murphy, Michelle ; Martorell, Lourdes ; Valero, Joaquín ; Simó, Josep Maria ; Joven, Jorge ; Fernández-Ballart, Joan ; Labad, Antonio</creatorcontrib><description>It has been suggested that total plasma homocysteine (tHcy) concentrations and methylenetetrahydrofolate reductase (
MTHFR) gene polymorphisms are risk factors for schizophrenia. We conducted a case-control study to investigate whether tHcy levels and
MTHFR C677T and A1298C variants are associated with schizophrenia, giving special consideration to confounding factors. Logistic regression analysis showed that neither tHcy nor
MTHFR polymorphisms were associated with schizophrenia. Homozygosity for
MTHFR C677T was associated with higher tHcy concentrations in control and schizophrenia groups (
P
<
0.01), which was mainly driven by the male group. The A1298C variant did not show any association with tHcy concentrations. In conclusion, these results do not confirm an independent relationship of tHcy and
MTHFR genotype with risk of schizophrenia.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2005.07.001</identifier><identifier>PMID: 16076517</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adult ; Aged ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Homocysteine ; Homocysteine - blood ; Humans ; Hyperhomocysteinemia - blood ; Hyperhomocysteinemia - etiology ; Logistic Models ; Male ; Methylenetetrahydrofolate reductase ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Middle Aged ; Polymorphism, Genetic ; Retrospective Studies ; Risk Factors ; Schizophrenia ; Schizophrenia - epidemiology ; Schizophrenia - genetics ; Sex Factors</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2005-09, Vol.29 (7), p.1169-1174</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-2a0ff8b05ac52b31a63f1efe4213b464216b417af8a22e59a4f2096308753e1c3</citedby><cites>FETCH-LOGICAL-c357t-2a0ff8b05ac52b31a63f1efe4213b464216b417af8a22e59a4f2096308753e1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pnpbp.2005.07.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16076517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vilella, Elisabet</creatorcontrib><creatorcontrib>Virgos, Carmen</creatorcontrib><creatorcontrib>Murphy, Michelle</creatorcontrib><creatorcontrib>Martorell, Lourdes</creatorcontrib><creatorcontrib>Valero, Joaquín</creatorcontrib><creatorcontrib>Simó, Josep Maria</creatorcontrib><creatorcontrib>Joven, Jorge</creatorcontrib><creatorcontrib>Fernández-Ballart, Joan</creatorcontrib><creatorcontrib>Labad, Antonio</creatorcontrib><title>Further evidence that hyperhomocysteinemia and methylenetetrahydrofolate reductase C677T and A1289C polymorphisms are not risk factors for schizophrenia</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>It has been suggested that total plasma homocysteine (tHcy) concentrations and methylenetetrahydrofolate reductase (
MTHFR) gene polymorphisms are risk factors for schizophrenia. We conducted a case-control study to investigate whether tHcy levels and
MTHFR C677T and A1298C variants are associated with schizophrenia, giving special consideration to confounding factors. Logistic regression analysis showed that neither tHcy nor
MTHFR polymorphisms were associated with schizophrenia. Homozygosity for
MTHFR C677T was associated with higher tHcy concentrations in control and schizophrenia groups (
P
<
0.01), which was mainly driven by the male group. The A1298C variant did not show any association with tHcy concentrations. In conclusion, these results do not confirm an independent relationship of tHcy and
MTHFR genotype with risk of schizophrenia.</description><subject>Adult</subject><subject>Aged</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Hyperhomocysteinemia - blood</subject><subject>Hyperhomocysteinemia - etiology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Methylenetetrahydrofolate reductase</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Schizophrenia</subject><subject>Schizophrenia - epidemiology</subject><subject>Schizophrenia - genetics</subject><subject>Sex Factors</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kb-O1DAQhy0E4paFJ0BCrug2-E9iZwuK0-oOkE6iOWrLccaKlyQOY-ek8CQ8LsntSnRUM8U3M5rfR8h7zgrOuPp0LqZxaqZCMFYVTBeM8Rdkx2tdH0rB1UuyY2Ltq7pUN-RNSme2EpLJ1-SGK6ZVxfWO_LmfMXeAFJ5CC6MDmjubabdMgF0coltShjDCECy1Y0sHyN3SwwgZMtpuaTH62NsMFKGdXbYJ6Elp_fhM33JRH090iv0yRJy6kIZELQIdY6YY0k_qrcsRE_URaXJd-B2nDmEM9i155W2f4N217smP-7vH09fDw_cv3063DwcnK50PwjLv64ZV1lWikdwq6Tl4WBOQTam2IJqSa-trKwRUR1t6wY5KslpXEriTe_LxsnfC-GuGlM0QkoO-tyPEORlVq0qUUq6gvIAOY0oI3kwYBouL4cxsQszZPAsxmxDDtNni3pMP1_VzM0D7b-ZqYAU-XwBYn3wKgCa5sIloA4LLpo3hvwf-AuBQoJg</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Vilella, Elisabet</creator><creator>Virgos, Carmen</creator><creator>Murphy, Michelle</creator><creator>Martorell, Lourdes</creator><creator>Valero, Joaquín</creator><creator>Simó, Josep Maria</creator><creator>Joven, Jorge</creator><creator>Fernández-Ballart, Joan</creator><creator>Labad, Antonio</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Further evidence that hyperhomocysteinemia and methylenetetrahydrofolate reductase C677T and A1289C polymorphisms are not risk factors for schizophrenia</title><author>Vilella, Elisabet ; Virgos, Carmen ; Murphy, Michelle ; Martorell, Lourdes ; Valero, Joaquín ; Simó, Josep Maria ; Joven, Jorge ; Fernández-Ballart, Joan ; Labad, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-2a0ff8b05ac52b31a63f1efe4213b464216b417af8a22e59a4f2096308753e1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Hyperhomocysteinemia - blood</topic><topic>Hyperhomocysteinemia - etiology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Methylenetetrahydrofolate reductase</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Schizophrenia</topic><topic>Schizophrenia - epidemiology</topic><topic>Schizophrenia - genetics</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vilella, Elisabet</creatorcontrib><creatorcontrib>Virgos, Carmen</creatorcontrib><creatorcontrib>Murphy, Michelle</creatorcontrib><creatorcontrib>Martorell, Lourdes</creatorcontrib><creatorcontrib>Valero, Joaquín</creatorcontrib><creatorcontrib>Simó, Josep Maria</creatorcontrib><creatorcontrib>Joven, Jorge</creatorcontrib><creatorcontrib>Fernández-Ballart, Joan</creatorcontrib><creatorcontrib>Labad, Antonio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vilella, Elisabet</au><au>Virgos, Carmen</au><au>Murphy, Michelle</au><au>Martorell, Lourdes</au><au>Valero, Joaquín</au><au>Simó, Josep Maria</au><au>Joven, Jorge</au><au>Fernández-Ballart, Joan</au><au>Labad, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Further evidence that hyperhomocysteinemia and methylenetetrahydrofolate reductase C677T and A1289C polymorphisms are not risk factors for schizophrenia</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>29</volume><issue>7</issue><spage>1169</spage><epage>1174</epage><pages>1169-1174</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><abstract>It has been suggested that total plasma homocysteine (tHcy) concentrations and methylenetetrahydrofolate reductase (
MTHFR) gene polymorphisms are risk factors for schizophrenia. We conducted a case-control study to investigate whether tHcy levels and
MTHFR C677T and A1298C variants are associated with schizophrenia, giving special consideration to confounding factors. Logistic regression analysis showed that neither tHcy nor
MTHFR polymorphisms were associated with schizophrenia. Homozygosity for
MTHFR C677T was associated with higher tHcy concentrations in control and schizophrenia groups (
P
<
0.01), which was mainly driven by the male group. The A1298C variant did not show any association with tHcy concentrations. In conclusion, these results do not confirm an independent relationship of tHcy and
MTHFR genotype with risk of schizophrenia.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>16076517</pmid><doi>10.1016/j.pnpbp.2005.07.001</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-5846 |
| ispartof | Progress in neuro-psychopharmacology & biological psychiatry, 2005-09, Vol.29 (7), p.1169-1174 |
| issn | 0278-5846 1878-4216 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68652433 |
| source | ScienceDirect; MEDLINE |
| subjects | Adult Aged Case-Control Studies Female Gene Frequency Genetic Predisposition to Disease Genotype Homocysteine Homocysteine - blood Humans Hyperhomocysteinemia - blood Hyperhomocysteinemia - etiology Logistic Models Male Methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) - genetics Middle Aged Polymorphism, Genetic Retrospective Studies Risk Factors Schizophrenia Schizophrenia - epidemiology Schizophrenia - genetics Sex Factors |
| title | Further evidence that hyperhomocysteinemia and methylenetetrahydrofolate reductase C677T and A1289C polymorphisms are not risk factors for schizophrenia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T15%3A04%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Further%20evidence%20that%20hyperhomocysteinemia%20and%20methylenetetrahydrofolate%20reductase%20C677T%20and%20A1289C%20polymorphisms%20are%20not%20risk%20factors%20for%20schizophrenia&rft.jtitle=Progress%20in%20neuro-psychopharmacology%20&%20biological%20psychiatry&rft.au=Vilella,%20Elisabet&rft.date=2005-09-01&rft.volume=29&rft.issue=7&rft.spage=1169&rft.epage=1174&rft.pages=1169-1174&rft.issn=0278-5846&rft.eissn=1878-4216&rft_id=info:doi/10.1016/j.pnpbp.2005.07.001&rft_dat=%3Cproquest_cross%3E68652433%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68652433&rft_id=info:pmid/16076517&rft_els_id=S0278584605002241&rfr_iscdi=true |