Successful rescue therapy with darunabir (TMC114) in HIV-infected patients who have failed several ritonavir-boosted protease inhibitors

Darunabir, formerly TMC114, is a new protease inhibitor (PI) under clinical development designed to be active against HIV strains resistant to currently available PI. The virological and immunological response to ritonavir-boosted darunabir was assessed in four heavily antiretroviral-experienced pat...

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Veröffentlicht in:	AIDS (London) 2006-07, Vol.20 (11), p.1558-1560
Hauptverfasser:	POVEDA, Eva, BLANCO, Francisco, GARCIA-GASCO, Pilar, ALCOLEA, Antonio, BRIZ, Veronica, SORIANO, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active Antiviral agents Biological and medical sciences Darunavir Drug Resistance, Viral HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV Protease Inhibitors - therapeutic use HIV-1 - drug effects HIV-1 - genetics Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Medical sciences Pharmacology. Drug treatments Ritonavir - therapeutic use RNA, Viral - blood Salvage Therapy - methods Sulfonamides - therapeutic use Treatment Failure Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load
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