Germinal center and activated B-cell profiles separate burkitt lymphoma and diffuse large B-cell lymphoma in AIDS and non-AIDS cases
Morphologic features of Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) overlap. No single phenotypic marker or molecular abnormality is pathognomonic. We tested a panel of 8 germinal center (GC) and activated B-cell (ABC) markers for their ability to separate BL and DLBCL. We diagno...
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| Veröffentlicht in: | American journal of clinical pathology 2005-11, Vol.124 (5), p.790-798 |
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| creator | GORMLEY, Robert P MADAN, Rashna RAMESH, K. H PULIJAAL, Venkat CAUUIZZARO, Linda WALSH, Daniel IOACHIM, Harry L RATECH, Howard DULAU, Alina E DONGSHENG XU TAMAS, Ecaterina F BHATTACHARYYA, Pritish K LEVALLEY, Aaron XIAONAN XUE KUMAR, Pankaj SPARANO, Joseph |
| description | Morphologic features of Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) overlap. No single phenotypic marker or molecular abnormality is pathognomonic. We tested a panel of 8 germinal center (GC) and activated B-cell (ABC) markers for their ability to separate BL and DLBCL. We diagnosed 16 BL and 39 DLBCL cases from 21 patients with AIDS and 34 without AIDS based on traditional morphologic criteria, Ki-67 proliferative index, and c-myc rearrangement (fluorescence in situ hybridization). After immunohistochemically staining tissue microarrays of BL and DLBCL for markers of GC (bcl-6, CD10, cyclin H) and ABC (MUM1, CD138, PAK1, CD44, bcl-2), we scored each case for the percentage of positive cells. Hierarchical clustering yielded 2 major clusters significantly associated with morphologic diagnosis (P < .001). For comparison, we plotted the sum of the GC scores and ABC scores for each case as x and y data points. This revealed a high-GC/low-ABC group and a low-GC/high-ABC group that were associated significantly with morphologic diagnosis (P < .001). Protein expression of multiple GC and ABC markers can separate BL and DLBCL. |
| doi_str_mv | 10.1309/7CEAWV0DNLLUWQTF |
| format | Article |
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H ; PULIJAAL, Venkat ; CAUUIZZARO, Linda ; WALSH, Daniel ; IOACHIM, Harry L ; RATECH, Howard ; DULAU, Alina E ; DONGSHENG XU ; TAMAS, Ecaterina F ; BHATTACHARYYA, Pritish K ; LEVALLEY, Aaron ; XIAONAN XUE ; KUMAR, Pankaj ; SPARANO, Joseph</creator><creatorcontrib>GORMLEY, Robert P ; MADAN, Rashna ; RAMESH, K. H ; PULIJAAL, Venkat ; CAUUIZZARO, Linda ; WALSH, Daniel ; IOACHIM, Harry L ; RATECH, Howard ; DULAU, Alina E ; DONGSHENG XU ; TAMAS, Ecaterina F ; BHATTACHARYYA, Pritish K ; LEVALLEY, Aaron ; XIAONAN XUE ; KUMAR, Pankaj ; SPARANO, Joseph</creatorcontrib><description>Morphologic features of Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) overlap. No single phenotypic marker or molecular abnormality is pathognomonic. We tested a panel of 8 germinal center (GC) and activated B-cell (ABC) markers for their ability to separate BL and DLBCL. We diagnosed 16 BL and 39 DLBCL cases from 21 patients with AIDS and 34 without AIDS based on traditional morphologic criteria, Ki-67 proliferative index, and c-myc rearrangement (fluorescence in situ hybridization). After immunohistochemically staining tissue microarrays of BL and DLBCL for markers of GC (bcl-6, CD10, cyclin H) and ABC (MUM1, CD138, PAK1, CD44, bcl-2), we scored each case for the percentage of positive cells. Hierarchical clustering yielded 2 major clusters significantly associated with morphologic diagnosis (P < .001). For comparison, we plotted the sum of the GC scores and ABC scores for each case as x and y data points. This revealed a high-GC/low-ABC group and a low-GC/high-ABC group that were associated significantly with morphologic diagnosis (P < .001). Protein expression of multiple GC and ABC markers can separate BL and DLBCL.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1309/7CEAWV0DNLLUWQTF</identifier><identifier>PMID: 16203284</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Adolescent ; Adult ; Aged ; B-Lymphocytes - immunology ; Biological and medical sciences ; Burkitt Lymphoma - diagnosis ; Burkitt Lymphoma - immunology ; Burkitt Lymphoma - pathology ; Child ; Child, Preschool ; Diagnosis, Differential ; Female ; Germinal Center - immunology ; Hematologic and hematopoietic diseases ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphocyte Activation ; Lymphoma, AIDS-Related - diagnosis ; Lymphoma, AIDS-Related - immunology ; Lymphoma, AIDS-Related - pathology ; Lymphoma, B-Cell - diagnosis ; Lymphoma, B-Cell - immunology ; Lymphoma, B-Cell - pathology ; Lymphoma, Large B-Cell, Diffuse - diagnosis ; Lymphoma, Large B-Cell, Diffuse - immunology ; Lymphoma, Large B-Cell, Diffuse - pathology ; Male ; Medical sciences ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Retrospective Studies</subject><ispartof>American journal of clinical pathology, 2005-11, Vol.124 (5), p.790-798</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-344bd33ed5f31011e7103c63d96da696c1ce564a0f4a3802d9fb60a89f03c95c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17217445$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16203284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GORMLEY, Robert P</creatorcontrib><creatorcontrib>MADAN, Rashna</creatorcontrib><creatorcontrib>RAMESH, K. H</creatorcontrib><creatorcontrib>PULIJAAL, Venkat</creatorcontrib><creatorcontrib>CAUUIZZARO, Linda</creatorcontrib><creatorcontrib>WALSH, Daniel</creatorcontrib><creatorcontrib>IOACHIM, Harry L</creatorcontrib><creatorcontrib>RATECH, Howard</creatorcontrib><creatorcontrib>DULAU, Alina E</creatorcontrib><creatorcontrib>DONGSHENG XU</creatorcontrib><creatorcontrib>TAMAS, Ecaterina F</creatorcontrib><creatorcontrib>BHATTACHARYYA, Pritish K</creatorcontrib><creatorcontrib>LEVALLEY, Aaron</creatorcontrib><creatorcontrib>XIAONAN XUE</creatorcontrib><creatorcontrib>KUMAR, Pankaj</creatorcontrib><creatorcontrib>SPARANO, Joseph</creatorcontrib><title>Germinal center and activated B-cell profiles separate burkitt lymphoma and diffuse large B-cell lymphoma in AIDS and non-AIDS cases</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Morphologic features of Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) overlap. No single phenotypic marker or molecular abnormality is pathognomonic. We tested a panel of 8 germinal center (GC) and activated B-cell (ABC) markers for their ability to separate BL and DLBCL. We diagnosed 16 BL and 39 DLBCL cases from 21 patients with AIDS and 34 without AIDS based on traditional morphologic criteria, Ki-67 proliferative index, and c-myc rearrangement (fluorescence in situ hybridization). After immunohistochemically staining tissue microarrays of BL and DLBCL for markers of GC (bcl-6, CD10, cyclin H) and ABC (MUM1, CD138, PAK1, CD44, bcl-2), we scored each case for the percentage of positive cells. Hierarchical clustering yielded 2 major clusters significantly associated with morphologic diagnosis (P < .001). For comparison, we plotted the sum of the GC scores and ABC scores for each case as x and y data points. This revealed a high-GC/low-ABC group and a low-GC/high-ABC group that were associated significantly with morphologic diagnosis (P < .001). Protein expression of multiple GC and ABC markers can separate BL and DLBCL.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Burkitt Lymphoma - diagnosis</subject><subject>Burkitt Lymphoma - immunology</subject><subject>Burkitt Lymphoma - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Germinal Center - immunology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphocyte Activation</subject><subject>Lymphoma, AIDS-Related - diagnosis</subject><subject>Lymphoma, AIDS-Related - immunology</subject><subject>Lymphoma, AIDS-Related - pathology</subject><subject>Lymphoma, B-Cell - diagnosis</subject><subject>Lymphoma, B-Cell - immunology</subject><subject>Lymphoma, B-Cell - pathology</subject><subject>Lymphoma, Large B-Cell, Diffuse - diagnosis</subject><subject>Lymphoma, Large B-Cell, Diffuse - immunology</subject><subject>Lymphoma, Large B-Cell, Diffuse - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Retrospective Studies</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1P3DAQBmALtSoL7Z1T5Ut7SzuOHSc-bpePIq2KEFCO0aw9LoZ8bO0EiXt_eMOyBakXTpbl5x159DJ2IOCLkGC-louj-fVPOPyxXF5dn18e77CZMEpmZZnnb9gMAPLMiFLusr2UbgFEXoF6x3aFzkHmlZqxPycU29Bhwy11A0WOneNoh3CPAzn-LbPUNHwdex8aSjzRGuP0wldjvAvDwJuHdn3Tt7jJueD9mIg3GH_Rv-yzCB2fnx5ebGTXd9nmYjFRes_eemwSfdie--zq-Ohy8T1bnp2cLubLzCqAIZNKrZyU5AovBQhBpQBptXRGO9RGW2Gp0ArBK5QV5M74lQasjJ-YKazcZ5-f5k77_B4pDXUb0uMnsaN-TLWutKpKoV6FwmgJujAThCdoY59SJF-vY2gxPtQC6seK6v8rmiIft7PHVUvuJbDtZAKftgCTxcZH7GxIL67MRalUIf8CSOmatA</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>GORMLEY, Robert P</creator><creator>MADAN, Rashna</creator><creator>RAMESH, K. 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H ; PULIJAAL, Venkat ; CAUUIZZARO, Linda ; WALSH, Daniel ; IOACHIM, Harry L ; RATECH, Howard ; DULAU, Alina E ; DONGSHENG XU ; TAMAS, Ecaterina F ; BHATTACHARYYA, Pritish K ; LEVALLEY, Aaron ; XIAONAN XUE ; KUMAR, Pankaj ; SPARANO, Joseph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-344bd33ed5f31011e7103c63d96da696c1ce564a0f4a3802d9fb60a89f03c95c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Burkitt Lymphoma - diagnosis</topic><topic>Burkitt Lymphoma - immunology</topic><topic>Burkitt Lymphoma - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Germinal Center - immunology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphocyte Activation</topic><topic>Lymphoma, AIDS-Related - diagnosis</topic><topic>Lymphoma, AIDS-Related - immunology</topic><topic>Lymphoma, AIDS-Related - pathology</topic><topic>Lymphoma, B-Cell - diagnosis</topic><topic>Lymphoma, B-Cell - immunology</topic><topic>Lymphoma, B-Cell - pathology</topic><topic>Lymphoma, Large B-Cell, Diffuse - diagnosis</topic><topic>Lymphoma, Large B-Cell, Diffuse - immunology</topic><topic>Lymphoma, Large B-Cell, Diffuse - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GORMLEY, Robert P</creatorcontrib><creatorcontrib>MADAN, Rashna</creatorcontrib><creatorcontrib>RAMESH, K. 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H</au><au>PULIJAAL, Venkat</au><au>CAUUIZZARO, Linda</au><au>WALSH, Daniel</au><au>IOACHIM, Harry L</au><au>RATECH, Howard</au><au>DULAU, Alina E</au><au>DONGSHENG XU</au><au>TAMAS, Ecaterina F</au><au>BHATTACHARYYA, Pritish K</au><au>LEVALLEY, Aaron</au><au>XIAONAN XUE</au><au>KUMAR, Pankaj</au><au>SPARANO, Joseph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Germinal center and activated B-cell profiles separate burkitt lymphoma and diffuse large B-cell lymphoma in AIDS and non-AIDS cases</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>124</volume><issue>5</issue><spage>790</spage><epage>798</epage><pages>790-798</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>Morphologic features of Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) overlap. No single phenotypic marker or molecular abnormality is pathognomonic. We tested a panel of 8 germinal center (GC) and activated B-cell (ABC) markers for their ability to separate BL and DLBCL. We diagnosed 16 BL and 39 DLBCL cases from 21 patients with AIDS and 34 without AIDS based on traditional morphologic criteria, Ki-67 proliferative index, and c-myc rearrangement (fluorescence in situ hybridization). After immunohistochemically staining tissue microarrays of BL and DLBCL for markers of GC (bcl-6, CD10, cyclin H) and ABC (MUM1, CD138, PAK1, CD44, bcl-2), we scored each case for the percentage of positive cells. Hierarchical clustering yielded 2 major clusters significantly associated with morphologic diagnosis (P < .001). For comparison, we plotted the sum of the GC scores and ABC scores for each case as x and y data points. This revealed a high-GC/low-ABC group and a low-GC/high-ABC group that were associated significantly with morphologic diagnosis (P < .001). Protein expression of multiple GC and ABC markers can separate BL and DLBCL.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>16203284</pmid><doi>10.1309/7CEAWV0DNLLUWQTF</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged B-Lymphocytes - immunology Biological and medical sciences Burkitt Lymphoma - diagnosis Burkitt Lymphoma - immunology Burkitt Lymphoma - pathology Child Child, Preschool Diagnosis, Differential Female Germinal Center - immunology Hematologic and hematopoietic diseases Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocyte Activation Lymphoma, AIDS-Related - diagnosis Lymphoma, AIDS-Related - immunology Lymphoma, AIDS-Related - pathology Lymphoma, B-Cell - diagnosis Lymphoma, B-Cell - immunology Lymphoma, B-Cell - pathology Lymphoma, Large B-Cell, Diffuse - diagnosis Lymphoma, Large B-Cell, Diffuse - immunology Lymphoma, Large B-Cell, Diffuse - pathology Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Retrospective Studies |
| title | Germinal center and activated B-cell profiles separate burkitt lymphoma and diffuse large B-cell lymphoma in AIDS and non-AIDS cases |
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