Induction of apoptosis in human lung cancer cells following treatment with amifostine and an adenoviral vector containing wild-type p53

Adenoviral delivery of the p53 gene is a potential therapeutic approach for the treatment of lung cancer. Furthermore, amifostine is a cytoprotective agent and recent reports have described its potentiation of chemotherapy's antitumor activity in lung cancer. Therefore, we wished to investigate...

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Veröffentlicht in:	Cancer gene therapy 2006-08, Vol.13 (8), p.806-814
Hauptverfasser:	Pataer, A, Fanale, M A, Roth, J A, Swisher, S G, Hunt, K K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Amifostine Amifostine - therapeutic use Antineoplastic Agents - therapeutic use Antitumor activity Apoptosis Apoptosis - drug effects Apoptosis - genetics BAX protein bcl-2 Homologous Antagonist-Killer Protein - genetics Bcl-2 protein bcl-2-Associated X Protein - genetics Biomedical and Life Sciences Biomedicine Cancer therapies Care and treatment Cdc2 protein CDC2 Protein Kinase - physiology Cell Line Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chemotherapy Combined Modality Therapy Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - genetics Dephosphorylation Dosage and administration Enzyme inhibitors Epithelial cells Gene Expression Gene Therapy Genes, bcl-2 - genetics Genes, p53 - genetics Genetic aspects Genetic Therapy - methods Genetic Vectors Health aspects Humans Kinases Lung cancer Lung Neoplasms - genetics Lung Neoplasms - therapy original-article p53 Protein Tumor suppressor genes
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