Surface-Enhanced Raman Scattering in Local Optical Fields of Silver and Gold NanoaggregatesFrom Single-Molecule Raman Spectroscopy to Ultrasensitive Probing in Live Cells
This Account discusses surface-enhanced Raman scattering at extremely high enhancement levels that can occur for molecules attached to silver and gold nanoclusters. Strongly enhanced and highly confined local optical fields enable surface-enhanced Stokes and anti-Stokes Raman spectroscopy of single...
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| Veröffentlicht in: | Accounts of chemical research 2006-07, Vol.39 (7), p.443-450 |
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| creator | Kneipp, Katrin Kneipp, Harald Kneipp, Janina |
| description | This Account discusses surface-enhanced Raman scattering at extremely high enhancement levels that can occur for molecules attached to silver and gold nanoclusters. Strongly enhanced and highly confined local optical fields enable surface-enhanced Stokes and anti-Stokes Raman spectroscopy of single molecules even under nonresonant excitation conditions as well as extremely large effective cross sections in two-photon excited Raman spectroscopy. The ability for very sensitive and spatially confined molecular structural probing makes gold and silver nanoclusters very promising tools for studies of small structures in biological materials, such as cellular compartments. |
| doi_str_mv | 10.1021/ar050107x |
| format | Article |
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Chem. Res</addtitle><description>This Account discusses surface-enhanced Raman scattering at extremely high enhancement levels that can occur for molecules attached to silver and gold nanoclusters. Strongly enhanced and highly confined local optical fields enable surface-enhanced Stokes and anti-Stokes Raman spectroscopy of single molecules even under nonresonant excitation conditions as well as extremely large effective cross sections in two-photon excited Raman spectroscopy. The ability for very sensitive and spatially confined molecular structural probing makes gold and silver nanoclusters very promising tools for studies of small structures in biological materials, such as cellular compartments.</description><subject>Cells</subject><subject>Gold - chemistry</subject><subject>Metal Nanoparticles</subject><subject>Molecular Probes</subject><subject>Sensitivity and Specificity</subject><subject>Silver - chemistry</subject><subject>Spectrum Analysis, Raman - methods</subject><subject>Surface Properties</subject><issn>0001-4842</issn><issn>1520-4898</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc9u1DAQxiMEokvhwAsgX-AWsBPHzh7RqluQdumKbM_WxJkNLo692E7VPglP0Xufimcgq-32NPNpfppv_mTZe0Y_M1qwLxBoRRmVdy-yGasKmvN6Xr_MZpRSNuW8OMvexHgzyYIL-To7Y6LmoqD1LHtoxrADjfmF-wVOY0d-wgCONBpSwmBcT4wjK6_Bkqt9Moe4NGi7SPyONMbeYiDgOnLpbUd-gPPQ9wF7SBj__X1cBj9MlOst5mtvUY8WTw571Cn4qP3-niRPrm0KENFFk8wtkk3w7cn9oBdobXybvdqBjfjuKZ5n18uL7eJbvrq6_L74usqBzYuUI-86XcuqbLlgAkqKlazqtqMArW4pZ6LgZctq0Zad1Fgjb6cqL4uCV6WgsjzPPh377oP_M2JMajBRTxOAQz9GJWrBZcHmE_jhCRzbATu1D2aAcK9OB56A_AiYmPDuuQ7htxKylJXabhrVrOW62WxrtZn4j0cedFQ3fgxu2lMxqg6PVs-PLv8D9o6bJg</recordid><startdate>200607</startdate><enddate>200607</enddate><creator>Kneipp, Katrin</creator><creator>Kneipp, Harald</creator><creator>Kneipp, Janina</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200607</creationdate><title>Surface-Enhanced Raman Scattering in Local Optical Fields of Silver and Gold NanoaggregatesFrom Single-Molecule Raman Spectroscopy to Ultrasensitive Probing in Live Cells</title><author>Kneipp, Katrin ; Kneipp, Harald ; Kneipp, Janina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a192t-e4ddc8753b4616a30e5758bd0aabcb0416243b186b3d7ce8e4b8bd43224536073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Cells</topic><topic>Gold - chemistry</topic><topic>Metal Nanoparticles</topic><topic>Molecular Probes</topic><topic>Sensitivity and Specificity</topic><topic>Silver - chemistry</topic><topic>Spectrum Analysis, Raman - methods</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kneipp, Katrin</creatorcontrib><creatorcontrib>Kneipp, Harald</creatorcontrib><creatorcontrib>Kneipp, Janina</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Accounts of chemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kneipp, Katrin</au><au>Kneipp, Harald</au><au>Kneipp, Janina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surface-Enhanced Raman Scattering in Local Optical Fields of Silver and Gold NanoaggregatesFrom Single-Molecule Raman Spectroscopy to Ultrasensitive Probing in Live Cells</atitle><jtitle>Accounts of chemical research</jtitle><addtitle>Acc. 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| ispartof | Accounts of chemical research, 2006-07, Vol.39 (7), p.443-450 |
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| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Cells Gold - chemistry Metal Nanoparticles Molecular Probes Sensitivity and Specificity Silver - chemistry Spectrum Analysis, Raman - methods Surface Properties |
| title | Surface-Enhanced Raman Scattering in Local Optical Fields of Silver and Gold NanoaggregatesFrom Single-Molecule Raman Spectroscopy to Ultrasensitive Probing in Live Cells |
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