Identification and characterization of an asparaginyl proteinase (legumain) from the parasitic nematode, Haemonchus contortus

Asparaginyl proteinases (or legumains) are a recently identified, novel class of cysteine proteinase which specifically hydrolyse peptide bonds after asparagine residues. Legumains have been implicated in the activation of cysteine proteases, particularly cathepsin B-like proteinases which are thoug...

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Veröffentlicht in:	Parasitology 2006-08, Vol.133 (2), p.237-244
Hauptverfasser:	OLIVER, E. M., SKUCE, P. J., McNAIR, C. M., KNOX, D. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence amino acid sequences Amino acids Animals Antigens Base Sequence Biological and medical sciences Blotting, Western Cloning, Molecular Cysteine Endopeptidases - chemistry Cysteine Endopeptidases - genetics Cysteine Endopeptidases - isolation & purification cysteine proteinases E coli enzyme activity enzyme inhibition Enzymes Fundamental and applied biological sciences. Psychology gastrointestinal nematodes gene expression Gene Expression Regulation, Enzymologic General aspects General aspects and techniques. Study of several systematic groups. Models Haemonchus - classification Haemonchus - enzymology Haemonchus contortus Humans Immunization immunolocalization Invertebrates legumain Life Cycle Stages localization microvilli Molecular Sequence Data Molecular Weight Nemathelminthia. Plathelmintha nucleotide sequences Parasites Phylogeny proteinase inhibitors Rats recombinant proteins Reverse Transcriptase Polymerase Chain Reaction sequence homology Sequence Homology, Amino Acid Sheep Studies tissue distribution
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