Plasma nitrate values in patients with obsessive‐compulsive disorder
Recently there has been increasing evidence that free oxygen species may play an important role in the pathophysiology of various neuropsychiatric disorders. The present study was performed to assess the changes in plasma nitric oxide (NO) levels in patients with obsessive‐compulsive disorder (OCD)...
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| Veröffentlicht in: | Psychiatry and clinical neurosciences 2005-10, Vol.59 (5), p.621-623 |
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| creator | ATMACA, MURAD TEZCAN, ERTAN KULOGLU, MURAT USTUNDAG, BILAL |
| description | Recently there has been increasing evidence that free oxygen species may play an important role in the pathophysiology of various neuropsychiatric disorders. The present study was performed to assess the changes in plasma nitric oxide (NO) levels in patients with obsessive‐compulsive disorder (OCD) compared to age‐ and sex‐matched normal controls. Twenty‐three patients with OCD and 23 healthy volunteers were included in the study. NO values were determined in the plasma of normal healthy controls and the OCD patients. Plasma nitrate levels in OCD patients were significantly higher than those in controls and were significantly and positively correlated with Yale‐Brown Obsession Compulsion Scale scores but not related to age or to the duration of illness. These findings indicated a possible role of increased NO may be relevant to the pathophysiology of OCD. |
| doi_str_mv | 10.1111/j.1440-1819.2005.01426.x |
| format | Article |
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The present study was performed to assess the changes in plasma nitric oxide (NO) levels in patients with obsessive‐compulsive disorder (OCD) compared to age‐ and sex‐matched normal controls. Twenty‐three patients with OCD and 23 healthy volunteers were included in the study. NO values were determined in the plasma of normal healthy controls and the OCD patients. Plasma nitrate levels in OCD patients were significantly higher than those in controls and were significantly and positively correlated with Yale‐Brown Obsession Compulsion Scale scores but not related to age or to the duration of illness. 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The present study was performed to assess the changes in plasma nitric oxide (NO) levels in patients with obsessive‐compulsive disorder (OCD) compared to age‐ and sex‐matched normal controls. Twenty‐three patients with OCD and 23 healthy volunteers were included in the study. NO values were determined in the plasma of normal healthy controls and the OCD patients. Plasma nitrate levels in OCD patients were significantly higher than those in controls and were significantly and positively correlated with Yale‐Brown Obsession Compulsion Scale scores but not related to age or to the duration of illness. These findings indicated a possible role of increased NO may be relevant to the pathophysiology of OCD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aging - metabolism</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitrates - blood</subject><subject>nitric</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>Obsessive-Compulsive Disorder - blood</subject><subject>Obsessive-compulsive disorders</subject><subject>Obsessive-Compulsive neuroses</subject><subject>obsessive‐compulsive disorder</subject><subject>oxide</subject><subject>Pathophysiological aspects</subject><subject>pathophysiology</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Neuroses</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nitrates - blood</topic><topic>nitric</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - blood</topic><topic>Obsessive-Compulsive Disorder - blood</topic><topic>Obsessive-compulsive disorders</topic><topic>Obsessive-Compulsive neuroses</topic><topic>obsessive‐compulsive disorder</topic><topic>oxide</topic><topic>Pathophysiological aspects</topic><topic>pathophysiology</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ATMACA, MURAD</creatorcontrib><creatorcontrib>TEZCAN, ERTAN</creatorcontrib><creatorcontrib>KULOGLU, MURAT</creatorcontrib><creatorcontrib>USTUNDAG, BILAL</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ATMACA, MURAD</au><au>TEZCAN, ERTAN</au><au>KULOGLU, MURAT</au><au>USTUNDAG, BILAL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma nitrate values in patients with obsessive‐compulsive disorder</atitle><jtitle>Psychiatry and clinical neurosciences</jtitle><addtitle>Psychiatry Clin Neurosci</addtitle><date>2005-10</date><risdate>2005</risdate><volume>59</volume><issue>5</issue><spage>621</spage><epage>623</epage><pages>621-623</pages><issn>1323-1316</issn><eissn>1440-1819</eissn><coden>PCNEFP</coden><abstract>Recently there has been increasing evidence that free oxygen species may play an important role in the pathophysiology of various neuropsychiatric disorders. The present study was performed to assess the changes in plasma nitric oxide (NO) levels in patients with obsessive‐compulsive disorder (OCD) compared to age‐ and sex‐matched normal controls. Twenty‐three patients with OCD and 23 healthy volunteers were included in the study. NO values were determined in the plasma of normal healthy controls and the OCD patients. Plasma nitrate levels in OCD patients were significantly higher than those in controls and were significantly and positively correlated with Yale‐Brown Obsession Compulsion Scale scores but not related to age or to the duration of illness. These findings indicated a possible role of increased NO may be relevant to the pathophysiology of OCD.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>16194270</pmid><doi>10.1111/j.1440-1819.2005.01426.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Adult and adolescent clinical studies Aging - metabolism Anxiety disorders. Neuroses Biological and medical sciences Female Humans Male Medical sciences Nitrates - blood nitric Nitric oxide Nitric Oxide - blood Obsessive-Compulsive Disorder - blood Obsessive-compulsive disorders Obsessive-Compulsive neuroses obsessive‐compulsive disorder oxide Pathophysiological aspects pathophysiology Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | Plasma nitrate values in patients with obsessive‐compulsive disorder |
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