Interaction of measles virus vectors with Auger electron emitting radioisotopes

A recombinant measles virus (MV) expressing the sodium iodide symporter (NIS) is being considered for therapy of advanced multiple myeloma. Auger electrons selectively damage cells in which the isotope decays. We hypothesized that the Auger electron emitting isotope 125I can be used to control viral...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-11, Vol.337 (1), p.22-29
Hauptverfasser:	Dingli, David, Peng, Kah-Whye, Harvey, Mary E., Vongpunsawad, Sompong, Bergert, Elizabeth R., Kyle, Robert A., Cattaneo, Roberto, Morris, John C., Russell, Stephen J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - blood Auger electron Carcinoembryonic Antigen - genetics Cell Line, Tumor Cercopithecus aethiops Electrons Female Free Radicals - metabolism Genetic Vectors - radiation effects Iodide Iodine Radioisotopes Measles virus Measles virus - genetics Measles virus - immunology Measles virus - radiation effects Mice Multiple myeloma Multiple Myeloma - immunology Multiple Myeloma - therapy Sodium iodide symporter Symporters - genetics Vero Cells Virotherapy Virus Replication - radiation effects Xenograft Model Antitumor Assays
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