Imaging the optic nerve in multiple sclerosis
Although multiple sclerosis (MS) frequently involves the optic nerves, imaging this structure is not yet performed routinely in clinical practice. The recent improvement of magnetic resonance (MR) technology and the development of new MR strategies, capable of providing an, in vivo, overall assessme...
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| Veröffentlicht in: | Multiple sclerosis 2005-10, Vol.11 (5), p.537-541 |
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| container_title | Multiple sclerosis |
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| creator | Rocca, M A Hickman, S J Bö, L Agosta, F Miller, D H Comi, G Filippi, M |
| description | Although multiple sclerosis (MS) frequently involves the optic nerves, imaging this structure is not yet performed routinely in clinical practice. The recent improvement of magnetic resonance (MR) technology and the development of new MR strategies, capable of providing an, in vivo, overall assessment of MS pathology has allowed objective metrics to be obtained for monitoring disease evolution, essentially in the brain. However, despite this progress, the correlation between brain MR metrics of the disease and clinical disability are still disappointing. An objective and accurate estimate of the presence and extent of optic nerve involvement might help to overcome this clinical/MRI paradox. This review summarizes the main results obtained from the application of conventional and modern MR-based techniques for the evaluation of optic nerve damage in MS. |
| doi_str_mv | 10.1191/1352458505ms1213oa |
| format | Article |
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The recent improvement of magnetic resonance (MR) technology and the development of new MR strategies, capable of providing an, in vivo, overall assessment of MS pathology has allowed objective metrics to be obtained for monitoring disease evolution, essentially in the brain. However, despite this progress, the correlation between brain MR metrics of the disease and clinical disability are still disappointing. An objective and accurate estimate of the presence and extent of optic nerve involvement might help to overcome this clinical/MRI paradox. This review summarizes the main results obtained from the application of conventional and modern MR-based techniques for the evaluation of optic nerve damage in MS.</description><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Multiple Sclerosis - pathology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Optic Nerve - pathology</subject><subject>Optic Neuritis - pathology</subject><subject>Pharmacology. 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| subjects | Atrophy Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Humans Immunomodulators Magnetic Resonance Imaging Medical sciences Multiple Sclerosis - pathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Optic Nerve - pathology Optic Neuritis - pathology Pharmacology. Drug treatments |
| title | Imaging the optic nerve in multiple sclerosis |
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