Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1
Visfatin has been originally identified as a growth factor for early stage B cells and recently known as an adipokine. Here, we report that hypoxia induces the visfatin mRNA and protein levels in MCF7 breast cancer cells. We also demonstrate that induction of visfatin gene is regulated by hypoxia-in...
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| Veröffentlicht in: | FEBS letters 2006-07, Vol.580 (17), p.4105-4113 |
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| creator | Bae, Soo-Kyung Kim, Su-Ryun Kim, Jong Gab Kim, Jee Yeon Koo, Tae Hyeon Jang, Hye-Ock Yun, Il Yoo, Mi-Ae Bae, Moon-Kyoung |
| description | Visfatin has been originally identified as a growth factor for early stage B cells and recently known as an adipokine. Here, we report that hypoxia induces the visfatin mRNA and protein levels in MCF7 breast cancer cells. We also demonstrate that induction of visfatin gene is regulated by hypoxia-inducible factor-1α (HIF-1α). Moreover, 5′-flanking promoter region of human visfatin gene contains two functional HIF responsive elements (HREs), activating the expression of visfatin. Mutation of these HREs in the visfatin promoter abrogates activation of a luciferase reporter gene driven by visfatin promoter under hypoxia. Taken together, our results demonstrate that visfatin is a new hypoxia-inducible gene of which expression is stimulated through the interaction of HIF-1 with HRE sites in its promoter region. |
| doi_str_mv | 10.1016/j.febslet.2006.06.052 |
| format | Article |
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Here, we report that hypoxia induces the visfatin mRNA and protein levels in MCF7 breast cancer cells. We also demonstrate that induction of visfatin gene is regulated by hypoxia-inducible factor-1α (HIF-1α). Moreover, 5′-flanking promoter region of human visfatin gene contains two functional HIF responsive elements (HREs), activating the expression of visfatin. Mutation of these HREs in the visfatin promoter abrogates activation of a luciferase reporter gene driven by visfatin promoter under hypoxia. Taken together, our results demonstrate that visfatin is a new hypoxia-inducible gene of which expression is stimulated through the interaction of HIF-1 with HRE sites in its promoter region.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2006.06.052</identifier><identifier>PMID: 16828081</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>B-Lymphocytes - metabolism ; Breast cancer cells ; Cell Hypoxia - physiology ; Cell Line, Tumor ; Cytokines - biosynthesis ; Cytokines - genetics ; Gene Expression Regulation - physiology ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism ; Hypoxia-inducible factor-1α ; Mutation ; Nicotinamide Phosphoribosyltransferase ; Pre-B-cell colony-enhancing factor ; Protein Binding - physiology ; Response Elements - physiology ; RNA, Messenger - biosynthesis ; RNA, Messenger - genetics ; Visfatin</subject><ispartof>FEBS letters, 2006-07, Vol.580 (17), p.4105-4113</ispartof><rights>2006 Federation of European Biochemical Societies</rights><rights>FEBS Letters 580 (2006) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5721-6bd764bad0d68ff5306f8fbfa460dfa6a8480af124e1984f4602fe47138488c53</citedby><cites>FETCH-LOGICAL-c5721-6bd764bad0d68ff5306f8fbfa460dfa6a8480af124e1984f4602fe47138488c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2006.06.052$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.febslet.2006.06.052$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,1433,3550,27924,27925,45574,45575,45995,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16828081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bae, Soo-Kyung</creatorcontrib><creatorcontrib>Kim, Su-Ryun</creatorcontrib><creatorcontrib>Kim, Jong Gab</creatorcontrib><creatorcontrib>Kim, Jee Yeon</creatorcontrib><creatorcontrib>Koo, Tae Hyeon</creatorcontrib><creatorcontrib>Jang, Hye-Ock</creatorcontrib><creatorcontrib>Yun, Il</creatorcontrib><creatorcontrib>Yoo, Mi-Ae</creatorcontrib><creatorcontrib>Bae, Moon-Kyoung</creatorcontrib><title>Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Visfatin has been originally identified as a growth factor for early stage B cells and recently known as an adipokine. Here, we report that hypoxia induces the visfatin mRNA and protein levels in MCF7 breast cancer cells. We also demonstrate that induction of visfatin gene is regulated by hypoxia-inducible factor-1α (HIF-1α). Moreover, 5′-flanking promoter region of human visfatin gene contains two functional HIF responsive elements (HREs), activating the expression of visfatin. Mutation of these HREs in the visfatin promoter abrogates activation of a luciferase reporter gene driven by visfatin promoter under hypoxia. Taken together, our results demonstrate that visfatin is a new hypoxia-inducible gene of which expression is stimulated through the interaction of HIF-1 with HRE sites in its promoter region.</description><subject>B-Lymphocytes - metabolism</subject><subject>Breast cancer cells</subject><subject>Cell Hypoxia - physiology</subject><subject>Cell Line, Tumor</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - genetics</subject><subject>Gene Expression Regulation - physiology</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - metabolism</subject><subject>Hypoxia-inducible factor-1α</subject><subject>Mutation</subject><subject>Nicotinamide Phosphoribosyltransferase</subject><subject>Pre-B-cell colony-enhancing factor</subject><subject>Protein Binding - physiology</subject><subject>Response Elements - physiology</subject><subject>RNA, Messenger - biosynthesis</subject><subject>RNA, Messenger - genetics</subject><subject>Visfatin</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctOxCAUhonROOPoI2hYuesIvVC6Mmocx8TEhbpyQSgcHCa9jKVV-_ZS28SlJichwH8-yHcQOqVkSQllF9ulgdwV0C5DQthyqCTcQ3PK0yiIYsb30ZwQGgdJmkUzdOTclvg9p9khmlHGQ044naPXdb-rv6zCttKdam1d4drgTVfKCn9YZ2RrK_wGFWDrsLYNqLbocQnayhY0znu8-QHI4Adg8wKwkaqtm4AeowMjCwcn07pAL6vb55t18PB4d39z9RCoJA1pwHKdsjiXmmjGjUkiwgw3uZExI9pIJnnMiTQ0jIFmPDb-ODQQpzTyF1wl0QKdj9xdU7934FpRWqegKGQFdecE4yzKEv53kGapl8ioDyZjUDW1cw0YsWtsKZteUCIG_WIrJv1i0C-GSkLfdzY90OXe0W_X5NsH1mPg0xbQ_48qVrfX4dMwy2GUhBGSsmxAXY4o8Go_LDTCKQuVgnFKQtf2j99-A18ZrsQ</recordid><startdate>20060724</startdate><enddate>20060724</enddate><creator>Bae, Soo-Kyung</creator><creator>Kim, Su-Ryun</creator><creator>Kim, Jong Gab</creator><creator>Kim, Jee Yeon</creator><creator>Koo, Tae Hyeon</creator><creator>Jang, Hye-Ock</creator><creator>Yun, Il</creator><creator>Yoo, Mi-Ae</creator><creator>Bae, Moon-Kyoung</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060724</creationdate><title>Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1</title><author>Bae, Soo-Kyung ; 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Here, we report that hypoxia induces the visfatin mRNA and protein levels in MCF7 breast cancer cells. We also demonstrate that induction of visfatin gene is regulated by hypoxia-inducible factor-1α (HIF-1α). Moreover, 5′-flanking promoter region of human visfatin gene contains two functional HIF responsive elements (HREs), activating the expression of visfatin. Mutation of these HREs in the visfatin promoter abrogates activation of a luciferase reporter gene driven by visfatin promoter under hypoxia. Taken together, our results demonstrate that visfatin is a new hypoxia-inducible gene of which expression is stimulated through the interaction of HIF-1 with HRE sites in its promoter region.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>16828081</pmid><doi>10.1016/j.febslet.2006.06.052</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Wiley Online Library (Open Access Collection); Alma/SFX Local Collection |
| subjects | B-Lymphocytes - metabolism Breast cancer cells Cell Hypoxia - physiology Cell Line, Tumor Cytokines - biosynthesis Cytokines - genetics Gene Expression Regulation - physiology Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor-1α Mutation Nicotinamide Phosphoribosyltransferase Pre-B-cell colony-enhancing factor Protein Binding - physiology Response Elements - physiology RNA, Messenger - biosynthesis RNA, Messenger - genetics Visfatin |
| title | Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1 |
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