Identification of residues crucially involved in soluble guanylate cyclase activation

The ubiquitous heterodimeric nitric oxide (NO) receptor soluble guanylate cyclase (sGC) plays a key role in various signal transduction pathways. Binding of NO takes place at the prosthetic heme moiety at the N-terminus of the β 1-subunit of sGC. The induced structural changes lead to an activation...

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Veröffentlicht in:	FEBS letters 2006-07, Vol.580 (17), p.4205-4213
Hauptverfasser:	Rothkegel, Christiane, Schmidt, Peter M., Stoll, Friederike, Schröder, Henning, Schmidt, Harald H.H.W., Stasch, Johannes-Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bay 41-2272 BAY 58-2667 cGMP Cyclic GMP Cyclic GMP - chemistry Cyclic GMP - metabolism Enzyme Activation Guanylate Cyclase - chemistry Guanylate Cyclase - metabolism Heme Models, Molecular n.d Nitric oxide not detectable Protein Structure, Tertiary Rats relative light units RLUs sGC soluble guanylate cyclase Soluble guanylyl cyclase Structural Homology, Protein Structure-Activity Relationship Substrate Specificity Thermoanaerobacter - enzymology wild-type
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