Vascular Neointimal Formation and Signaling Pathway Activation in Response to Stent Injury in Insulin-Resistant and Diabetic Animals

Diabetes and insulin resistance are associated with increased disease risk and poor outcomes from cardiovascular interventions. Even drug-eluting stents exhibit reduced efficacy in patients with diabetes. We now report the first study of vascular response to stent injury in insulin-resistant and dia...

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Veröffentlicht in:	Circulation research 2005-09, Vol.97 (7), p.725-733
Hauptverfasser:	Jonas, Michael, Edelman, Elazer R, Groothuis, Adam, Baker, Aaron B, Seifert, Philip, Rogers, Campbell
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Extracellular Signal-Regulated MAP Kinases - metabolism Fundamental and applied biological sciences. Psychology Hyperglycemia - pathology Insulin Resistance Obesity - metabolism Obesity - pathology Protein Kinases - physiology Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Rats Rats, Sprague-Dawley Rats, Zucker Signal Transduction - physiology Stents - adverse effects Streptozocin TOR Serine-Threonine Kinases Tunica Intima - pathology Vertebrates: cardiovascular system
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