High survivin predicts a poor response to endocrine therapy, but a good response to chemotherapy in advanced breast cancer

Variants of survivin with differing subcellular localizations might mediate the different functions of survivin, i.e. cell-cycle regulation and apoptosis inhibition. Highly proliferative tumors are more sensitive to chemotherapy, whereas apoptosis resistant cells would be refractory to endocrine the...

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Veröffentlicht in:	Breast cancer research and treatment 2006-07, Vol.98 (2), p.223-230
Hauptverfasser:	SPAN, Paul N, TJAN-HEIJNEN, Vivianne C. G, MANDERS, Peggy, VAN TIENOVEN, Doorlene, LEHR, Jeffrey, SWEEP, Fred C. G. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Aromatase Inhibitors - therapeutic use Biological and medical sciences Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - drug therapy Breast Neoplasms - mortality Cancer research Cancer therapies Chemotherapy Endocrine therapy Enzyme-Linked Immunosorbent Assay Female Gynecology. Andrology. Obstetrics Hormones Humans Inhibitor of Apoptosis Proteins Mammary gland diseases Medical research Medical sciences Medroxyprogesterone Acetate - therapeutic use Microtubule-Associated Proteins - analysis Middle Aged Neoplasm Proteins - analysis Tamoxifen - therapeutic use Tumors
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