Gene order constrains adaptation in bacteriophage T7

The order of genes in the genome is commonly thought to have functional significance for gene regulation and fitness but has not heretofore been tested experimentally. We adapted a bacteriophage T7 variant harboring an ectopically positioned RNA polymerase gene to determine whether it could regain t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2005-10, Vol.341 (1), p.141-152
Hauptverfasser:	Springman, R., Badgett, M.R., Molineux, I.J., Bull, J.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - genetics Bacteria Bacteriophage Bacteriophage T7 - genetics Bacteriophage T7 - physiology Directed Molecular Evolution DNA, Viral - genetics DNA-Directed RNA Polymerases - genetics Escherichia coli K12 - virology Experimental evolution Gene Order Genome evolution Genome, Viral Microbial evolution Models, Genetic Molecular evolution Mutation Phage T7 Recombination, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!