Visceral Fat Analysis at CT Colonography
Obesity is associated with increased risks for colorectal neoplasia. Few studies have examined quantitative body fat measurements as predictors of colorectal polyps. The objective is to determine whether visceral fat is associated with colorectal polyps at computed tomography (CT) colonography. Case...
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| Veröffentlicht in: | Academic radiology 2006-08, Vol.13 (8), p.963-968 |
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| creator | Johnson, Kristina T. Harmsen, William S. Limburg, Paul J. Carston, Michael J. Johnson, Charles D. |
| description | Obesity is associated with increased risks for colorectal neoplasia. Few studies have examined quantitative body fat measurements as predictors of colorectal polyps. The objective is to determine whether visceral fat is associated with colorectal polyps at computed tomography (CT) colonography.
Case (
n = 25) and control (
n = 25) subjects with proven large (>1 cm) colorectal adenomas or normal colons respectively were randomly selected from among an established CT colonography research study cohort. Using supine CT colonography data, the body wall was traced at three levels: top of the right kidney, iliac crest, and superior acetabulum. Total area from the three slices and each slice area were determined within the visceral fat range (–170 to –45 Hounsfield units) and recorded within the selected region. Visceral fat measures were compared between patient groups with and without polyps.
None of the single slice visceral fat area measures or summed measures predicted case or control status. The most informative visceral fat measure was obtained at the top of the right kidney with a maximum area under the received operator characteristic curve of 0.77 (0.05 SE). For a selected sensitivity of 75%, the maximum specificity for a large (≥1 cm) polyp was 64%.
In this pilot study, visceral fat measures at CT colonography were not significantly associated with the presence of large colorectal adenomas. However, odd ratios were elevated by a factor of 2. This suggests that a larger study may be justified. |
| doi_str_mv | 10.1016/j.acra.2006.04.008 |
| format | Article |
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Case (
n = 25) and control (
n = 25) subjects with proven large (>1 cm) colorectal adenomas or normal colons respectively were randomly selected from among an established CT colonography research study cohort. Using supine CT colonography data, the body wall was traced at three levels: top of the right kidney, iliac crest, and superior acetabulum. Total area from the three slices and each slice area were determined within the visceral fat range (–170 to –45 Hounsfield units) and recorded within the selected region. Visceral fat measures were compared between patient groups with and without polyps.
None of the single slice visceral fat area measures or summed measures predicted case or control status. The most informative visceral fat measure was obtained at the top of the right kidney with a maximum area under the received operator characteristic curve of 0.77 (0.05 SE). For a selected sensitivity of 75%, the maximum specificity for a large (≥1 cm) polyp was 64%.
In this pilot study, visceral fat measures at CT colonography were not significantly associated with the presence of large colorectal adenomas. However, odd ratios were elevated by a factor of 2. This suggests that a larger study may be justified.</description><identifier>ISSN: 1076-6332</identifier><identifier>EISSN: 1878-4046</identifier><identifier>DOI: 10.1016/j.acra.2006.04.008</identifier><identifier>PMID: 16843848</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Case-Control Studies ; Colonic Polyps - diagnostic imaging ; Colonography, Computed Tomographic - methods ; Colonoscopy ; colorectal polyps ; CT colonography ; Female ; Humans ; Intra-Abdominal Fat - diagnostic imaging ; Logistic Models ; Male ; Middle Aged ; Pilot Projects ; ROC Curve ; Supine Position ; Visceral fat</subject><ispartof>Academic radiology, 2006-08, Vol.13 (8), p.963-968</ispartof><rights>2006 AUR</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-77ed90d614adf24ce4efb92d7ac1c8219d29e387a64fb6e661a388f5128d6bde3</citedby><cites>FETCH-LOGICAL-c416t-77ed90d614adf24ce4efb92d7ac1c8219d29e387a64fb6e661a388f5128d6bde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1076633206002601$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16843848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Kristina T.</creatorcontrib><creatorcontrib>Harmsen, William S.</creatorcontrib><creatorcontrib>Limburg, Paul J.</creatorcontrib><creatorcontrib>Carston, Michael J.</creatorcontrib><creatorcontrib>Johnson, Charles D.</creatorcontrib><title>Visceral Fat Analysis at CT Colonography</title><title>Academic radiology</title><addtitle>Acad Radiol</addtitle><description>Obesity is associated with increased risks for colorectal neoplasia. Few studies have examined quantitative body fat measurements as predictors of colorectal polyps. The objective is to determine whether visceral fat is associated with colorectal polyps at computed tomography (CT) colonography.
Case (
n = 25) and control (
n = 25) subjects with proven large (>1 cm) colorectal adenomas or normal colons respectively were randomly selected from among an established CT colonography research study cohort. Using supine CT colonography data, the body wall was traced at three levels: top of the right kidney, iliac crest, and superior acetabulum. Total area from the three slices and each slice area were determined within the visceral fat range (–170 to –45 Hounsfield units) and recorded within the selected region. Visceral fat measures were compared between patient groups with and without polyps.
None of the single slice visceral fat area measures or summed measures predicted case or control status. The most informative visceral fat measure was obtained at the top of the right kidney with a maximum area under the received operator characteristic curve of 0.77 (0.05 SE). For a selected sensitivity of 75%, the maximum specificity for a large (≥1 cm) polyp was 64%.
In this pilot study, visceral fat measures at CT colonography were not significantly associated with the presence of large colorectal adenomas. However, odd ratios were elevated by a factor of 2. This suggests that a larger study may be justified.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Case-Control Studies</subject><subject>Colonic Polyps - diagnostic imaging</subject><subject>Colonography, Computed Tomographic - methods</subject><subject>Colonoscopy</subject><subject>colorectal polyps</subject><subject>CT colonography</subject><subject>Female</subject><subject>Humans</subject><subject>Intra-Abdominal Fat - diagnostic imaging</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>ROC Curve</subject><subject>Supine Position</subject><subject>Visceral fat</subject><issn>1076-6332</issn><issn>1878-4046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AURQdRbK3-AReSlbhJnK-8TMCNBKtCwU11O0xmXjQlTepMKvTfm9CCO7t6d3Hu5XEIuWY0YZTB_Sox1puEUwoJlQml6oRMmcpULKmE0yHTDGIQgk_IRQgrSlkKSpyTCQMlhZJqSu4-6mDRmyaamz56bE2zC3WIhlwso6Jrurb79GbztbskZ5VpAl4d7oy8z5-WxUu8eHt-LR4XsZUM-jjL0OXUAZPGVVxalFiVOXeZscwqznLHcxQqMyCrEhCAGaFUlTKuHJQOxYzc7nc3vvveYuj1evywaUyL3TZoUCAyLtOjoOBcqJE-BnJGRSryEeR70PouBI-V3vh6bfxOM6pH43qlR-N6NK6p1IPxoXRzWN-Wa3R_lYPiAXjYAzhY-6nR62BrbC262qPttevq__Z_AeUTj-k</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Johnson, Kristina T.</creator><creator>Harmsen, William S.</creator><creator>Limburg, Paul J.</creator><creator>Carston, Michael J.</creator><creator>Johnson, Charles D.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7U5</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>Visceral Fat Analysis at CT Colonography</title><author>Johnson, Kristina T. ; Harmsen, William S. ; Limburg, Paul J. ; Carston, Michael J. ; Johnson, Charles D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-77ed90d614adf24ce4efb92d7ac1c8219d29e387a64fb6e661a388f5128d6bde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Case-Control Studies</topic><topic>Colonic Polyps - diagnostic imaging</topic><topic>Colonography, Computed Tomographic - methods</topic><topic>Colonoscopy</topic><topic>colorectal polyps</topic><topic>CT colonography</topic><topic>Female</topic><topic>Humans</topic><topic>Intra-Abdominal Fat - diagnostic imaging</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>ROC Curve</topic><topic>Supine Position</topic><topic>Visceral fat</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Kristina T.</creatorcontrib><creatorcontrib>Harmsen, William S.</creatorcontrib><creatorcontrib>Limburg, Paul J.</creatorcontrib><creatorcontrib>Carston, Michael J.</creatorcontrib><creatorcontrib>Johnson, Charles D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Academic radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Kristina T.</au><au>Harmsen, William S.</au><au>Limburg, Paul J.</au><au>Carston, Michael J.</au><au>Johnson, Charles D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visceral Fat Analysis at CT Colonography</atitle><jtitle>Academic radiology</jtitle><addtitle>Acad Radiol</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>13</volume><issue>8</issue><spage>963</spage><epage>968</epage><pages>963-968</pages><issn>1076-6332</issn><eissn>1878-4046</eissn><abstract>Obesity is associated with increased risks for colorectal neoplasia. Few studies have examined quantitative body fat measurements as predictors of colorectal polyps. The objective is to determine whether visceral fat is associated with colorectal polyps at computed tomography (CT) colonography.
Case (
n = 25) and control (
n = 25) subjects with proven large (>1 cm) colorectal adenomas or normal colons respectively were randomly selected from among an established CT colonography research study cohort. Using supine CT colonography data, the body wall was traced at three levels: top of the right kidney, iliac crest, and superior acetabulum. Total area from the three slices and each slice area were determined within the visceral fat range (–170 to –45 Hounsfield units) and recorded within the selected region. Visceral fat measures were compared between patient groups with and without polyps.
None of the single slice visceral fat area measures or summed measures predicted case or control status. The most informative visceral fat measure was obtained at the top of the right kidney with a maximum area under the received operator characteristic curve of 0.77 (0.05 SE). For a selected sensitivity of 75%, the maximum specificity for a large (≥1 cm) polyp was 64%.
In this pilot study, visceral fat measures at CT colonography were not significantly associated with the presence of large colorectal adenomas. However, odd ratios were elevated by a factor of 2. This suggests that a larger study may be justified.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16843848</pmid><doi>10.1016/j.acra.2006.04.008</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Case-Control Studies Colonic Polyps - diagnostic imaging Colonography, Computed Tomographic - methods Colonoscopy colorectal polyps CT colonography Female Humans Intra-Abdominal Fat - diagnostic imaging Logistic Models Male Middle Aged Pilot Projects ROC Curve Supine Position Visceral fat |
| title | Visceral Fat Analysis at CT Colonography |
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