Angiotensin-Converting Enzyme Inhibitors Slow Recovery From Anemia Following Cardiac Surgery
Angiotensin-converting enzyme (ACE) inhibitors, which are frequently administered in patients with heart disease, have a known inhibitory effect on erythropoiesis. The aim of this study was to detect whether early ACE inhibitor administration slows recovery from anemia following recent cardiac surge...
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| Veröffentlicht in: | Chest 2006-07, Vol.130 (1), p.79-84 |
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| creator | Ripamonti, Vittorino Racca, Vittorio Calvo, Maria G. Castiglioni, Paolo Ferratini, Maurizio |
| description | Angiotensin-converting enzyme (ACE) inhibitors, which are frequently administered in patients with heart disease, have a known inhibitory effect on erythropoiesis. The aim of this study was to detect whether early ACE inhibitor administration slows recovery from anemia following recent cardiac surgery.
Forty male patients with anemia (hemoglobin < 12 g/dL) an average of 9 days after cardiac surgery were randomized to receive enalapril (ACE inhibitor group) or not. All of the patients received ferrous sulfate, 525 mg, in addition to standard therapy. Patients with anemia due to other causes were excluded. Blood samples were obtained at baseline, and after 8 days, 16 days, and 60 days. A 6-min walking test and echocardioscan were performed at baseline, and after 16 days and 60 days of treatment, and a chest radiograph was obtained at baseline and after 60 days. The ACE inhibitor group showed a statistically significant lower increase in hemoglobin and RBC values. The peak between-group differences of 1 g/dL of hemoglobin (p = 0.012) and 444 RBCs per milliliter (p = 0.017) were observed on day 16.
Early enalapril maleate administration in anemic patients after heart surgery significantly inhibits erythropoiesis. This unfavorable effect on anemia should be considered when prescribing ACE inhibitors for such patients. |
| doi_str_mv | 10.1378/chest.130.1.79 |
| format | Article |
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Forty male patients with anemia (hemoglobin < 12 g/dL) an average of 9 days after cardiac surgery were randomized to receive enalapril (ACE inhibitor group) or not. All of the patients received ferrous sulfate, 525 mg, in addition to standard therapy. Patients with anemia due to other causes were excluded. Blood samples were obtained at baseline, and after 8 days, 16 days, and 60 days. A 6-min walking test and echocardioscan were performed at baseline, and after 16 days and 60 days of treatment, and a chest radiograph was obtained at baseline and after 60 days. The ACE inhibitor group showed a statistically significant lower increase in hemoglobin and RBC values. The peak between-group differences of 1 g/dL of hemoglobin (p = 0.012) and 444 RBCs per milliliter (p = 0.017) were observed on day 16.
Early enalapril maleate administration in anemic patients after heart surgery significantly inhibits erythropoiesis. This unfavorable effect on anemia should be considered when prescribing ACE inhibitors for such patients.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.130.1.79</identifier><identifier>PMID: 16840386</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>ACE inhibitors ; Anemia ; Anemia - drug therapy ; Anemias. Hemoglobinopathies ; angiotensin-converting enzyme inhibitors ; Angiotensin-Converting Enzyme Inhibitors - adverse effects ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Biological and medical sciences ; Blood transfusions ; Cardiac patients ; cardiac rehabilitation ; Cardiac Surgical Procedures ; Cardiology. Vascular system ; Cardiovascular disease ; Coronary vessels ; Creatinine ; Diseases of red blood cells ; Dosage and administration ; Drug therapy ; Ejection fraction ; Enalapril - adverse effects ; Enalapril - therapeutic use ; Enzymes ; Erythropoiesis - drug effects ; Health aspects ; Heart ; Heart surgery ; Hematologic and hematopoietic diseases ; Hemoglobin ; Hemoglobins - drug effects ; Humans ; Male ; Medical sciences ; Middle Aged ; Patient outcomes ; Pneumology ; Postoperative Period ; Stroke Volume - drug effects ; Surgery</subject><ispartof>Chest, 2006-07, Vol.130 (1), p.79-84</ispartof><rights>2006 The American College of Chest Physicians</rights><rights>2006 INIST-CNRS</rights><rights>COPYRIGHT 2006 Elsevier B.V.</rights><rights>Copyright American College of Chest Physicians Jul 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-5ec89c92cfa06c94c8c2952aba58058440abc7ff06ed8c9531664056a684ac7b3</citedby><cites>FETCH-LOGICAL-c515t-5ec89c92cfa06c94c8c2952aba58058440abc7ff06ed8c9531664056a684ac7b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17953350$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16840386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ripamonti, Vittorino</creatorcontrib><creatorcontrib>Racca, Vittorio</creatorcontrib><creatorcontrib>Calvo, Maria G.</creatorcontrib><creatorcontrib>Castiglioni, Paolo</creatorcontrib><creatorcontrib>Ferratini, Maurizio</creatorcontrib><title>Angiotensin-Converting Enzyme Inhibitors Slow Recovery From Anemia Following Cardiac Surgery</title><title>Chest</title><addtitle>Chest</addtitle><description>Angiotensin-converting enzyme (ACE) inhibitors, which are frequently administered in patients with heart disease, have a known inhibitory effect on erythropoiesis. The aim of this study was to detect whether early ACE inhibitor administration slows recovery from anemia following recent cardiac surgery.
Forty male patients with anemia (hemoglobin < 12 g/dL) an average of 9 days after cardiac surgery were randomized to receive enalapril (ACE inhibitor group) or not. All of the patients received ferrous sulfate, 525 mg, in addition to standard therapy. Patients with anemia due to other causes were excluded. Blood samples were obtained at baseline, and after 8 days, 16 days, and 60 days. A 6-min walking test and echocardioscan were performed at baseline, and after 16 days and 60 days of treatment, and a chest radiograph was obtained at baseline and after 60 days. The ACE inhibitor group showed a statistically significant lower increase in hemoglobin and RBC values. The peak between-group differences of 1 g/dL of hemoglobin (p = 0.012) and 444 RBCs per milliliter (p = 0.017) were observed on day 16.
Early enalapril maleate administration in anemic patients after heart surgery significantly inhibits erythropoiesis. This unfavorable effect on anemia should be considered when prescribing ACE inhibitors for such patients.</description><subject>ACE inhibitors</subject><subject>Anemia</subject><subject>Anemia - drug therapy</subject><subject>Anemias. Hemoglobinopathies</subject><subject>angiotensin-converting enzyme inhibitors</subject><subject>Angiotensin-Converting Enzyme Inhibitors - adverse effects</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood transfusions</subject><subject>Cardiac patients</subject><subject>cardiac rehabilitation</subject><subject>Cardiac Surgical Procedures</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Coronary vessels</subject><subject>Creatinine</subject><subject>Diseases of red blood cells</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Ejection fraction</subject><subject>Enalapril - adverse effects</subject><subject>Enalapril - therapeutic use</subject><subject>Enzymes</subject><subject>Erythropoiesis - drug effects</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart surgery</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemoglobin</subject><subject>Hemoglobins - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Patient outcomes</subject><subject>Pneumology</subject><subject>Postoperative Period</subject><subject>Stroke Volume - drug effects</subject><subject>Surgery</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kdFv0zAQxiMEYmXwyiOKkMZbih3HjvNYVSubNAmJwRuS5V4uqafEHna6qfz1XGmlTgiQH-yzf9_d-b4se8vZnItaf4QNpomOFM7r5lk2443ghZCVeJ7NGONlIVRTnmWvUrpjFPNGvczOuNIVE1rNsu8L37swoU_OF8vgHzBOzvf5pf-5GzG_9hu3dlOIKb8dwmP-BSEQsstXMYz5wuPobL4KA73tVUsbW2chv93GnqjX2YvODgnfHPfz7Nvq8uvyqrj5_Ol6ubgpQHI5FRJBN9CU0FmmoKlAQ9nI0q6t1EzqqmJ2DXXXMYWthkYKrlTFpLL0Cwv1WpxnHw5572P4saWBmNElwGGwHsM2GaWVqBkXBL7_A7wL2-ipN1MyVulaNiVBxQHq7YDG-S5M0UKPHqMdgsfO0fWCK7HnS0n8_C88rZamA_8TQAwpRezMfXSjjTvDmdm7an67SkcKTd2Q4N2x7e16xPaEH20k4OII2AR26KL14NKJq2loQrJT5Y3rN48uokmjHQZKKw41j-N4UlkfBEj2PTiMJoFDD9iSGCbTBvevpn8BZcbOtw</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Ripamonti, Vittorino</creator><creator>Racca, Vittorio</creator><creator>Calvo, Maria G.</creator><creator>Castiglioni, Paolo</creator><creator>Ferratini, Maurizio</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><general>Elsevier B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20060701</creationdate><title>Angiotensin-Converting Enzyme Inhibitors Slow Recovery From Anemia Following Cardiac Surgery</title><author>Ripamonti, Vittorino ; Racca, Vittorio ; Calvo, Maria G. ; Castiglioni, Paolo ; Ferratini, Maurizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-5ec89c92cfa06c94c8c2952aba58058440abc7ff06ed8c9531664056a684ac7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ACE inhibitors</topic><topic>Anemia</topic><topic>Anemia - drug therapy</topic><topic>Anemias. Hemoglobinopathies</topic><topic>angiotensin-converting enzyme inhibitors</topic><topic>Angiotensin-Converting Enzyme Inhibitors - adverse effects</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood transfusions</topic><topic>Cardiac patients</topic><topic>cardiac rehabilitation</topic><topic>Cardiac Surgical Procedures</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Coronary vessels</topic><topic>Creatinine</topic><topic>Diseases of red blood cells</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Ejection fraction</topic><topic>Enalapril - adverse effects</topic><topic>Enalapril - therapeutic use</topic><topic>Enzymes</topic><topic>Erythropoiesis - drug effects</topic><topic>Health aspects</topic><topic>Heart</topic><topic>Heart surgery</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemoglobin</topic><topic>Hemoglobins - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Patient outcomes</topic><topic>Pneumology</topic><topic>Postoperative Period</topic><topic>Stroke Volume - drug effects</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ripamonti, Vittorino</creatorcontrib><creatorcontrib>Racca, Vittorio</creatorcontrib><creatorcontrib>Calvo, Maria G.</creatorcontrib><creatorcontrib>Castiglioni, Paolo</creatorcontrib><creatorcontrib>Ferratini, Maurizio</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ripamonti, Vittorino</au><au>Racca, Vittorio</au><au>Calvo, Maria G.</au><au>Castiglioni, Paolo</au><au>Ferratini, Maurizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin-Converting Enzyme Inhibitors Slow Recovery From Anemia Following Cardiac Surgery</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>130</volume><issue>1</issue><spage>79</spage><epage>84</epage><pages>79-84</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Angiotensin-converting enzyme (ACE) inhibitors, which are frequently administered in patients with heart disease, have a known inhibitory effect on erythropoiesis. The aim of this study was to detect whether early ACE inhibitor administration slows recovery from anemia following recent cardiac surgery.
Forty male patients with anemia (hemoglobin < 12 g/dL) an average of 9 days after cardiac surgery were randomized to receive enalapril (ACE inhibitor group) or not. All of the patients received ferrous sulfate, 525 mg, in addition to standard therapy. Patients with anemia due to other causes were excluded. Blood samples were obtained at baseline, and after 8 days, 16 days, and 60 days. A 6-min walking test and echocardioscan were performed at baseline, and after 16 days and 60 days of treatment, and a chest radiograph was obtained at baseline and after 60 days. The ACE inhibitor group showed a statistically significant lower increase in hemoglobin and RBC values. The peak between-group differences of 1 g/dL of hemoglobin (p = 0.012) and 444 RBCs per milliliter (p = 0.017) were observed on day 16.
Early enalapril maleate administration in anemic patients after heart surgery significantly inhibits erythropoiesis. This unfavorable effect on anemia should be considered when prescribing ACE inhibitors for such patients.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>16840386</pmid><doi>10.1378/chest.130.1.79</doi><tpages>6</tpages></addata></record> |
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| subjects | ACE inhibitors Anemia Anemia - drug therapy Anemias. Hemoglobinopathies angiotensin-converting enzyme inhibitors Angiotensin-Converting Enzyme Inhibitors - adverse effects Angiotensin-Converting Enzyme Inhibitors - therapeutic use Biological and medical sciences Blood transfusions Cardiac patients cardiac rehabilitation Cardiac Surgical Procedures Cardiology. Vascular system Cardiovascular disease Coronary vessels Creatinine Diseases of red blood cells Dosage and administration Drug therapy Ejection fraction Enalapril - adverse effects Enalapril - therapeutic use Enzymes Erythropoiesis - drug effects Health aspects Heart Heart surgery Hematologic and hematopoietic diseases Hemoglobin Hemoglobins - drug effects Humans Male Medical sciences Middle Aged Patient outcomes Pneumology Postoperative Period Stroke Volume - drug effects Surgery |
| title | Angiotensin-Converting Enzyme Inhibitors Slow Recovery From Anemia Following Cardiac Surgery |
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