Improving Second-Generation Surveillance: The Biological Measure of Unprotected Intercourse Using Prostate-Specific Antigen in Vaginal Secretions of West African Women
BACKGROUND:Second-generation surveillance for HIV includes measures of high-risk behaviors among the general adult population and sex workers (SW). Questionnaires are prone to social desirability biases because individuals minimize the frequency of behaviors not expected from them. OBJECTIVE:Determi...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2006-08, Vol.42 (4), p.490-493 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
| container_volume | 42 |
| creator | Pépin, Jacques Fink, Guy D Khonde, Nzambi Sobela, Francois Deslandes, Sylvie Diakité, Soumaila Labbé, Annie-Claude Sylla, Mohamed Frost, Eric |
| description | BACKGROUND:Second-generation surveillance for HIV includes measures of high-risk behaviors among the general adult population and sex workers (SW). Questionnaires are prone to social desirability biases because individuals minimize the frequency of behaviors not expected from them.
OBJECTIVE:Determine whether the prostate-specific antigen (PSA) could be used as a biological marker of unprotected intercourse.
METHODS:We measured the presence of PSA in vaginal secretions of women who were (n = 508) or were not (n = 658) SW presenting with vaginal discharge in health facilities of Ghana, Togo, Guinea, and Mali. The cutoff for a positive assay was determined as ≥0.4 μg/L based on a subsample of 95 non-SW claiming abstinence for 3 months.
RESULTS:A positive PSA assay was correlated with infections with Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium. Among non-SW, a positive PSA was more common among those with HIV, but less frequent in those better educated. Among SW and non-SW, women from Ghana were less likely to have a positive PSA and had a lower prevalence of sexually transmitted infections than those from elsewhere.
CONCLUSIONS:PSA can be used as a biological marker of unprotected intercourse, allowing interventions to target efforts on those at highest risk. |
| doi_str_mv | 10.1097/01.qai.0000222286.52084.9c |
| format | Article |
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OBJECTIVE:Determine whether the prostate-specific antigen (PSA) could be used as a biological marker of unprotected intercourse.
METHODS:We measured the presence of PSA in vaginal secretions of women who were (n = 508) or were not (n = 658) SW presenting with vaginal discharge in health facilities of Ghana, Togo, Guinea, and Mali. The cutoff for a positive assay was determined as ≥0.4 μg/L based on a subsample of 95 non-SW claiming abstinence for 3 months.
RESULTS:A positive PSA assay was correlated with infections with Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium. Among non-SW, a positive PSA was more common among those with HIV, but less frequent in those better educated. Among SW and non-SW, women from Ghana were less likely to have a positive PSA and had a lower prevalence of sexually transmitted infections than those from elsewhere.
CONCLUSIONS:PSA can be used as a biological marker of unprotected intercourse, allowing interventions to target efforts on those at highest risk.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/01.qai.0000222286.52084.9c</identifier><identifier>PMID: 16773025</identifier><identifier>CODEN: JDSRET</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Africa, Western ; AIDS/HIV ; Antigens ; Biological and medical sciences ; Chlamydia trachomatis ; Female ; Fundamental and applied biological sciences. Psychology ; HIV ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Medical sciences ; Microbiology ; Miscellaneous ; Mycoplasma genitalium ; Neisseria gonorrhoeae ; Prostate-Specific Antigen - analysis ; Prostate-Specific Antigen - secretion ; Risk factors ; Sex industry ; Unsafe Sex ; Vagina - secretion ; Viral diseases ; Virology ; Womens health</subject><ispartof>Journal of acquired immune deficiency syndromes (1999), 2006-08, Vol.42 (4), p.490-493</ispartof><rights>2006 Lippincott Williams & Wilkins, Inc.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Aug 1, 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3936-56b716cf1b77d32f0ad6c8cfb714bb616a3533e0df90a41a620effe334fcfd743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf><![CDATA[$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&PDF=y&D=ovft&AN=00126334-200608010-00016$$EPDF$$P50$$Gwolterskluwer$$H]]></linktopdf><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00126334-200608010-00016$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,780,784,4609,27924,27925,64666,65461</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17982048$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16773025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pépin, Jacques</creatorcontrib><creatorcontrib>Fink, Guy D</creatorcontrib><creatorcontrib>Khonde, Nzambi</creatorcontrib><creatorcontrib>Sobela, Francois</creatorcontrib><creatorcontrib>Deslandes, Sylvie</creatorcontrib><creatorcontrib>Diakité, Soumaila</creatorcontrib><creatorcontrib>Labbé, Annie-Claude</creatorcontrib><creatorcontrib>Sylla, Mohamed</creatorcontrib><creatorcontrib>Frost, Eric</creatorcontrib><title>Improving Second-Generation Surveillance: The Biological Measure of Unprotected Intercourse Using Prostate-Specific Antigen in Vaginal Secretions of West African Women</title><title>Journal of acquired immune deficiency syndromes (1999)</title><addtitle>J Acquir Immune Defic Syndr</addtitle><description>BACKGROUND:Second-generation surveillance for HIV includes measures of high-risk behaviors among the general adult population and sex workers (SW). Questionnaires are prone to social desirability biases because individuals minimize the frequency of behaviors not expected from them.
OBJECTIVE:Determine whether the prostate-specific antigen (PSA) could be used as a biological marker of unprotected intercourse.
METHODS:We measured the presence of PSA in vaginal secretions of women who were (n = 508) or were not (n = 658) SW presenting with vaginal discharge in health facilities of Ghana, Togo, Guinea, and Mali. The cutoff for a positive assay was determined as ≥0.4 μg/L based on a subsample of 95 non-SW claiming abstinence for 3 months.
RESULTS:A positive PSA assay was correlated with infections with Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium. Among non-SW, a positive PSA was more common among those with HIV, but less frequent in those better educated. Among SW and non-SW, women from Ghana were less likely to have a positive PSA and had a lower prevalence of sexually transmitted infections than those from elsewhere.
CONCLUSIONS:PSA can be used as a biological marker of unprotected intercourse, allowing interventions to target efforts on those at highest risk.</description><subject>Africa, Western</subject><subject>AIDS/HIV</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Chlamydia trachomatis</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mycoplasma genitalium</subject><subject>Neisseria gonorrhoeae</subject><subject>Prostate-Specific Antigen - analysis</subject><subject>Prostate-Specific Antigen - secretion</subject><subject>Risk factors</subject><subject>Sex industry</subject><subject>Unsafe Sex</subject><subject>Vagina - secretion</subject><subject>Viral diseases</subject><subject>Virology</subject><subject>Womens health</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt9u0zAUxiMEYqPwCsiaBHcpx3_iJLsrE4xKQyB1ZZeR6xy3HqnT2ckmnojX5JRWqsQN58aW9fP3-ZzPWXbBYcqhLj8Anz4YPwUqQVXpaSGgUtPaPsvOea1UXlaVek77QhS54rI4y16ldA_AtVL1y-yM67KUIIrz7Pd8u4v9ow9rtkDbhza_xoDRDL4PbDHGR_RdZ4LFS3a7QfbR912_9tZ07CuaNEZkvWPLQBoD2gFbNg8DRtuPMSFbpr3u99inwQyYL3ZovfOWzcLg1xiYD-yHWftAamQecW-a9oJ3mAY2c5GMArvrtxheZy-c6RK-Oa6TbPn50-3Vl_zm2_X8anaTW1lLnRd6VXJtHV-VZSuFA9NqW1lHp2q10lwbWUiJ0LoajOJGC0DnUErlrGtLJSfZ-4MudfQw0jOarU8W9zPAfkyNrrTUWvwfFFxwLSUQePEPeE_ToZ6JkVJLKIibZJcHyNKwUkTX7KLfmvir4dDsQ2-ANxR6cwq9-Rt6U1u6_PboMK622J6uHlMm4N0RMImic5EC9enElXUlQFXEqQP31HeUYvrZjU8Ymw2abtiQNRfUkcoFgIYKOOSw_1LyD_iXyI4</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Pépin, Jacques</creator><creator>Fink, Guy D</creator><creator>Khonde, Nzambi</creator><creator>Sobela, Francois</creator><creator>Deslandes, Sylvie</creator><creator>Diakité, Soumaila</creator><creator>Labbé, Annie-Claude</creator><creator>Sylla, Mohamed</creator><creator>Frost, Eric</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7QL</scope><scope>7U1</scope><scope>7U2</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>Improving Second-Generation Surveillance: The Biological Measure of Unprotected Intercourse Using Prostate-Specific Antigen in Vaginal Secretions of West African Women</title><author>Pépin, Jacques ; Fink, Guy D ; Khonde, Nzambi ; Sobela, Francois ; Deslandes, Sylvie ; Diakité, Soumaila ; Labbé, Annie-Claude ; Sylla, Mohamed ; Frost, Eric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3936-56b716cf1b77d32f0ad6c8cfb714bb616a3533e0df90a41a620effe334fcfd743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Africa, Western</topic><topic>AIDS/HIV</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>Chlamydia trachomatis</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mycoplasma genitalium</topic><topic>Neisseria gonorrhoeae</topic><topic>Prostate-Specific Antigen - analysis</topic><topic>Prostate-Specific Antigen - secretion</topic><topic>Risk factors</topic><topic>Sex industry</topic><topic>Unsafe Sex</topic><topic>Vagina - secretion</topic><topic>Viral diseases</topic><topic>Virology</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pépin, Jacques</creatorcontrib><creatorcontrib>Fink, Guy D</creatorcontrib><creatorcontrib>Khonde, Nzambi</creatorcontrib><creatorcontrib>Sobela, Francois</creatorcontrib><creatorcontrib>Deslandes, Sylvie</creatorcontrib><creatorcontrib>Diakité, Soumaila</creatorcontrib><creatorcontrib>Labbé, Annie-Claude</creatorcontrib><creatorcontrib>Sylla, Mohamed</creatorcontrib><creatorcontrib>Frost, Eric</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pépin, Jacques</au><au>Fink, Guy D</au><au>Khonde, Nzambi</au><au>Sobela, Francois</au><au>Deslandes, Sylvie</au><au>Diakité, Soumaila</au><au>Labbé, Annie-Claude</au><au>Sylla, Mohamed</au><au>Frost, Eric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improving Second-Generation Surveillance: The Biological Measure of Unprotected Intercourse Using Prostate-Specific Antigen in Vaginal Secretions of West African Women</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>42</volume><issue>4</issue><spage>490</spage><epage>493</epage><pages>490-493</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><coden>JDSRET</coden><abstract>BACKGROUND:Second-generation surveillance for HIV includes measures of high-risk behaviors among the general adult population and sex workers (SW). Questionnaires are prone to social desirability biases because individuals minimize the frequency of behaviors not expected from them.
OBJECTIVE:Determine whether the prostate-specific antigen (PSA) could be used as a biological marker of unprotected intercourse.
METHODS:We measured the presence of PSA in vaginal secretions of women who were (n = 508) or were not (n = 658) SW presenting with vaginal discharge in health facilities of Ghana, Togo, Guinea, and Mali. The cutoff for a positive assay was determined as ≥0.4 μg/L based on a subsample of 95 non-SW claiming abstinence for 3 months.
RESULTS:A positive PSA assay was correlated with infections with Neisseria gonorrhoeae, Chlamydia trachomatis, and Mycoplasma genitalium. Among non-SW, a positive PSA was more common among those with HIV, but less frequent in those better educated. Among SW and non-SW, women from Ghana were less likely to have a positive PSA and had a lower prevalence of sexually transmitted infections than those from elsewhere.
CONCLUSIONS:PSA can be used as a biological marker of unprotected intercourse, allowing interventions to target efforts on those at highest risk.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>16773025</pmid><doi>10.1097/01.qai.0000222286.52084.9c</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of acquired immune deficiency syndromes (1999), 2006-08, Vol.42 (4), p.490-493 |
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| language | eng |
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| subjects | Africa, Western AIDS/HIV Antigens Biological and medical sciences Chlamydia trachomatis Female Fundamental and applied biological sciences. Psychology HIV Human immunodeficiency virus Human viral diseases Humans Infectious diseases Medical sciences Microbiology Miscellaneous Mycoplasma genitalium Neisseria gonorrhoeae Prostate-Specific Antigen - analysis Prostate-Specific Antigen - secretion Risk factors Sex industry Unsafe Sex Vagina - secretion Viral diseases Virology Womens health |
| title | Improving Second-Generation Surveillance: The Biological Measure of Unprotected Intercourse Using Prostate-Specific Antigen in Vaginal Secretions of West African Women |
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