Crystal Structures, Reactivity and Inferred Acylation Transition States for 2‘-Amine Substituted RNA

Ribose 2‘-amine substitutions are broadly useful as structural probes in nucleic acids. In addition, structure-selective chemical reaction at 2‘-amine groups is a robust technology for interrogating local nucleotide flexibility and conformational changes in RNA and DNA. We analyzed crystal structure...

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Veröffentlicht in:	Journal of the American Chemical Society 2005-10, Vol.127 (39), p.13622-13628
Hauptverfasser:	Gherghe, Costin M, Krahn, Joseph M, Weeks, Kevin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Base Sequence Biological and medical sciences Crystallography, X-Ray Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration Mechanisms. Catalysis. Electron transfer. Models Molecular biophysics Nucleic Acid Conformation Physical chemistry in biology RNA - chemistry
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