Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division

Understanding of the mechanisms governing spindle positioning during asymmetric division remains incomplete. During unequal division of one-cell stage C. elegans embryos, the Galpha proteins GOA-1 and GPA-16 act in a partially redundant manner to generate pulling forces along astral microtubules. Pr...

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Veröffentlicht in:	Development (Cambridge) 2005-10, Vol.132 (20), p.4449-4459
Hauptverfasser:	Afshar, Katayoun, Willard, Francis S, Colombo, Kelly, Siderovski, David P, Gönczy, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blastomeres - cytology Blastomeres - metabolism Caenorhabditis elegans - cytology Caenorhabditis elegans - embryology Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Division Cerebral Cortex - cytology Cerebral Cortex - embryology Cerebral Cortex - metabolism Embryo, Nonmammalian - cytology Embryo, Nonmammalian - metabolism Gene Expression Regulation, Developmental GTP-Binding Protein alpha Subunits - genetics GTP-Binding Protein alpha Subunits - metabolism Guanine Nucleotide Dissociation Inhibitors - metabolism Guanine Nucleotide Exchange Factors - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Time Factors
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