Hypoglycemic effect and chlorogenic acid content in two Cecropia species
The hypoglycemic effect of methanol leaf extracts from Cecropia obtusifolia and C. peltata was evaluated in healthy mice. A significant decrease (p < 0.05) in plasma glucose levels was recorded 2 and 4 h after a single oral administration of methanol extracts (1 g/kg). This effect was correlated...
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| Veröffentlicht in: | Phytotherapy research 2005-08, Vol.19 (8), p.661-664 |
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| description | The hypoglycemic effect of methanol leaf extracts from Cecropia obtusifolia and C. peltata was evaluated in healthy mice. A significant decrease (p < 0.05) in plasma glucose levels was recorded 2 and 4 h after a single oral administration of methanol extracts (1 g/kg). This effect was correlated with the chlorogenic acid contents in both species; C. peltata, containing 19.84 ± 1.64 mg of chlorogenic acid/g of dried leaves produced the highest decrease (Dα 2,60 = 20.18, p < 0.05) of plasma glucose levels (52.8%). The extracts of C. obtusifolia from Tabasco and Veracruz, showed similar hypoglycemic effects (33.3% and 35.7%, respectively) and chlorogenic acid contents (Tukey0.05 = 1.8859) (13.3 ± 3.2 mg/g and 13.1 ± 1.6 mg/g, respectively). The hypoglycemic effect produced by different doses (0.1, 0.25, 0.50, 0.75 and 1 g/kg body wt, p.o.) of C. peltata showed a lineal relationship with chlorogenic acid content, reaching an ED50 = 0.540 g/kg body wt for extract, and an ED50 = 10.8 mg/kg body wt for chlorogenic acid. These results suggest that C. peltata is a better hypoglycemic agent than C. obtusifolia, and it could be considered for developing a phytomedicinal product to carry out clinical trials. Copyright © 2005 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.1722 |
| format | Article |
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A significant decrease (p < 0.05) in plasma glucose levels was recorded 2 and 4 h after a single oral administration of methanol extracts (1 g/kg). This effect was correlated with the chlorogenic acid contents in both species; C. peltata, containing 19.84 ± 1.64 mg of chlorogenic acid/g of dried leaves produced the highest decrease (Dα 2,60 = 20.18, p < 0.05) of plasma glucose levels (52.8%). The extracts of C. obtusifolia from Tabasco and Veracruz, showed similar hypoglycemic effects (33.3% and 35.7%, respectively) and chlorogenic acid contents (Tukey0.05 = 1.8859) (13.3 ± 3.2 mg/g and 13.1 ± 1.6 mg/g, respectively). The hypoglycemic effect produced by different doses (0.1, 0.25, 0.50, 0.75 and 1 g/kg body wt, p.o.) of C. peltata showed a lineal relationship with chlorogenic acid content, reaching an ED50 = 0.540 g/kg body wt for extract, and an ED50 = 10.8 mg/kg body wt for chlorogenic acid. These results suggest that C. peltata is a better hypoglycemic agent than C. obtusifolia, and it could be considered for developing a phytomedicinal product to carry out clinical trials. Copyright © 2005 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.1722</identifier><identifier>PMID: 16177966</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - drug effects ; Cecropia obtusifolia ; Cecropia peltata ; Cecropia Plant - chemistry ; chlorogenic acid ; Chlorogenic Acid - analogs & derivatives ; Chlorogenic Acid - analysis ; Chlorogenic Acid - pharmacology ; Dose-Response Relationship, Drug ; General pharmacology ; guarumbo ; Hypoglycemic Agents - chemistry ; Hypoglycemic Agents - pharmacology ; hypoglycemic effect ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Molecular Structure ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts - chemistry ; Plant Leaves - chemistry ; type 2 diabetes mellitus</subject><ispartof>Phytotherapy research, 2005-08, Vol.19 (8), p.661-664</ispartof><rights>Copyright © 2005 John Wiley & Sons, Ltd.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright (c) 2005 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4112-b46caf0a0abdf92bb8735cf9e81a2297b7af05bac8e08849dac5c46ccdce16b03</citedby><cites>FETCH-LOGICAL-c4112-b46caf0a0abdf92bb8735cf9e81a2297b7af05bac8e08849dac5c46ccdce16b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.1722$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.1722$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17128325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16177966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nicasio, P</creatorcontrib><creatorcontrib>Aguilar-Santamaria, L</creatorcontrib><creatorcontrib>Aranda, E</creatorcontrib><creatorcontrib>Ortiz, S</creatorcontrib><creatorcontrib>Gonzalez, M</creatorcontrib><title>Hypoglycemic effect and chlorogenic acid content in two Cecropia species</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The hypoglycemic effect of methanol leaf extracts from Cecropia obtusifolia and C. peltata was evaluated in healthy mice. A significant decrease (p < 0.05) in plasma glucose levels was recorded 2 and 4 h after a single oral administration of methanol extracts (1 g/kg). This effect was correlated with the chlorogenic acid contents in both species; C. peltata, containing 19.84 ± 1.64 mg of chlorogenic acid/g of dried leaves produced the highest decrease (Dα 2,60 = 20.18, p < 0.05) of plasma glucose levels (52.8%). The extracts of C. obtusifolia from Tabasco and Veracruz, showed similar hypoglycemic effects (33.3% and 35.7%, respectively) and chlorogenic acid contents (Tukey0.05 = 1.8859) (13.3 ± 3.2 mg/g and 13.1 ± 1.6 mg/g, respectively). The hypoglycemic effect produced by different doses (0.1, 0.25, 0.50, 0.75 and 1 g/kg body wt, p.o.) of C. peltata showed a lineal relationship with chlorogenic acid content, reaching an ED50 = 0.540 g/kg body wt for extract, and an ED50 = 10.8 mg/kg body wt for chlorogenic acid. These results suggest that C. peltata is a better hypoglycemic agent than C. obtusifolia, and it could be considered for developing a phytomedicinal product to carry out clinical trials. Copyright © 2005 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - drug effects</subject><subject>Cecropia obtusifolia</subject><subject>Cecropia peltata</subject><subject>Cecropia Plant - chemistry</subject><subject>chlorogenic acid</subject><subject>Chlorogenic Acid - analogs & derivatives</subject><subject>Chlorogenic Acid - analysis</subject><subject>Chlorogenic Acid - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>General pharmacology</subject><subject>guarumbo</subject><subject>Hypoglycemic Agents - chemistry</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>hypoglycemic effect</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Molecular Structure</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Leaves - chemistry</subject><subject>type 2 diabetes mellitus</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10Etv1DAQB3ALgei2IPEJIBcqLike52H7WC3QRazKayu4Wc5kshiycbCzKvvtcbURPXGyNP7NQ3_GngG_AM7F63EKFyCFeMAWwLXOoZLFQ7bguoK8BPX9hJ3G-JNzrgUvH7MTqEFKXdcLtlodRr_tD0g7hxl1HeGU2aHN8Efvg9_SkMoWXSr4YaJhytyQTbc-WxIGPzqbxZHQUXzCHnW2j_R0fs_Yzbu3m-UqX3-8er-8XOdYAoi8KWu0HbfcNm2nRdMoWVTYaVJghdCykem3aiwq4kqVurVYYerBFgnqhhdn7Pw4dwz-957iZHYuIvW9Hcjvo6lVLbRSIsFXR5jujDFQZ8bgdjYcDHBzl5pJqZm71BJ9Ps_cNztq7-EcUwIvZ2Aj2r4LdkAX750EoQpRJZcf3a3r6fDfhebT5su8ePYuTvTnn7fhl6llISvz7frKbODNulQfPpvr5F8cfWe9sduQbrj5KjgUHHhRVqUq_gI9B5xr</recordid><startdate>200508</startdate><enddate>200508</enddate><creator>Nicasio, P</creator><creator>Aguilar-Santamaria, L</creator><creator>Aranda, E</creator><creator>Ortiz, S</creator><creator>Gonzalez, M</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200508</creationdate><title>Hypoglycemic effect and chlorogenic acid content in two Cecropia species</title><author>Nicasio, P ; Aguilar-Santamaria, L ; Aranda, E ; Ortiz, S ; Gonzalez, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4112-b46caf0a0abdf92bb8735cf9e81a2297b7af05bac8e08849dac5c46ccdce16b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - drug effects</topic><topic>Cecropia obtusifolia</topic><topic>Cecropia peltata</topic><topic>Cecropia Plant - chemistry</topic><topic>chlorogenic acid</topic><topic>Chlorogenic Acid - analogs & derivatives</topic><topic>Chlorogenic Acid - analysis</topic><topic>Chlorogenic Acid - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>General pharmacology</topic><topic>guarumbo</topic><topic>Hypoglycemic Agents - chemistry</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>hypoglycemic effect</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Molecular Structure</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Leaves - chemistry</topic><topic>type 2 diabetes mellitus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nicasio, P</creatorcontrib><creatorcontrib>Aguilar-Santamaria, L</creatorcontrib><creatorcontrib>Aranda, E</creatorcontrib><creatorcontrib>Ortiz, S</creatorcontrib><creatorcontrib>Gonzalez, M</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nicasio, P</au><au>Aguilar-Santamaria, L</au><au>Aranda, E</au><au>Ortiz, S</au><au>Gonzalez, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoglycemic effect and chlorogenic acid content in two Cecropia species</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2005-08</date><risdate>2005</risdate><volume>19</volume><issue>8</issue><spage>661</spage><epage>664</epage><pages>661-664</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>The hypoglycemic effect of methanol leaf extracts from Cecropia obtusifolia and C. peltata was evaluated in healthy mice. A significant decrease (p < 0.05) in plasma glucose levels was recorded 2 and 4 h after a single oral administration of methanol extracts (1 g/kg). This effect was correlated with the chlorogenic acid contents in both species; C. peltata, containing 19.84 ± 1.64 mg of chlorogenic acid/g of dried leaves produced the highest decrease (Dα 2,60 = 20.18, p < 0.05) of plasma glucose levels (52.8%). The extracts of C. obtusifolia from Tabasco and Veracruz, showed similar hypoglycemic effects (33.3% and 35.7%, respectively) and chlorogenic acid contents (Tukey0.05 = 1.8859) (13.3 ± 3.2 mg/g and 13.1 ± 1.6 mg/g, respectively). The hypoglycemic effect produced by different doses (0.1, 0.25, 0.50, 0.75 and 1 g/kg body wt, p.o.) of C. peltata showed a lineal relationship with chlorogenic acid content, reaching an ED50 = 0.540 g/kg body wt for extract, and an ED50 = 10.8 mg/kg body wt for chlorogenic acid. These results suggest that C. peltata is a better hypoglycemic agent than C. obtusifolia, and it could be considered for developing a phytomedicinal product to carry out clinical trials. Copyright © 2005 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>16177966</pmid><doi>10.1002/ptr.1722</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Blood Glucose - drug effects Cecropia obtusifolia Cecropia peltata Cecropia Plant - chemistry chlorogenic acid Chlorogenic Acid - analogs & derivatives Chlorogenic Acid - analysis Chlorogenic Acid - pharmacology Dose-Response Relationship, Drug General pharmacology guarumbo Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology hypoglycemic effect Male Medical sciences Mice Mice, Inbred BALB C Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Extracts - chemistry Plant Leaves - chemistry type 2 diabetes mellitus |
| title | Hypoglycemic effect and chlorogenic acid content in two Cecropia species |
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