Evaluation of the Structure-Function Relationship in Glaucoma
While glaucoma is evaluated on the basis of structural and functional test results, the spatial relationship between structure and function is not well defined. This study produces a topographical map to demonstrate how sectors of the optic nerve head (ONH) are related to locations in the visual fie...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 2005-10, Vol.46 (10), p.3712-3717 |
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| creator | Gardiner, Stuart K Johnson, Chris A Cioffi, George A |
| description | While glaucoma is evaluated on the basis of structural and functional test results, the spatial relationship between structure and function is not well defined. This study produces a topographical map to demonstrate how sectors of the optic nerve head (ONH) are related to locations in the visual field, using empiric cross-sectional patient data.
One hundred nine subjects with healthy eyes and 166 subjects with diagnosed or suspected glaucoma (one test per patient) were evaluated using a retina tomograph and white-on-white standard automated perimetry (SAP). The tomograph ONH images were divided into 36 sectors; and the sector rim areas normalized to account for changes in the total rim area. These were then correlated with SAP thresholds. For each visual field location, a map was produced indicating the strength of correlation between the normalized sector rim areas and thresholds.
The highest correlation between a sector's normalized rim area and a SAP location's sensitivity was 0.520. Twenty-seven of the 52 non-blind spot SAP locations exhibited a correlation greater than 0.2 with at least one ONH sector. Locations in the superior hemifield were usually best correlated with the polar inferior temporal sectors of the ONH; locations in the inferior hemifield were usually best correlated with the polar superior temporal sectors of the ONH.
A map relating regions of the ONH to SAP test locations has been produced. This map may be useful in elucidating the structure-function relationship, particularly for cases of localized glaucomatous loss. |
| doi_str_mv | 10.1167/iovs.05-0266 |
| format | Article |
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One hundred nine subjects with healthy eyes and 166 subjects with diagnosed or suspected glaucoma (one test per patient) were evaluated using a retina tomograph and white-on-white standard automated perimetry (SAP). The tomograph ONH images were divided into 36 sectors; and the sector rim areas normalized to account for changes in the total rim area. These were then correlated with SAP thresholds. For each visual field location, a map was produced indicating the strength of correlation between the normalized sector rim areas and thresholds.
The highest correlation between a sector's normalized rim area and a SAP location's sensitivity was 0.520. Twenty-seven of the 52 non-blind spot SAP locations exhibited a correlation greater than 0.2 with at least one ONH sector. Locations in the superior hemifield were usually best correlated with the polar inferior temporal sectors of the ONH; locations in the inferior hemifield were usually best correlated with the polar superior temporal sectors of the ONH.
A map relating regions of the ONH to SAP test locations has been produced. This map may be useful in elucidating the structure-function relationship, particularly for cases of localized glaucomatous loss.</description><identifier>ISSN: 0146-0404</identifier><identifier>ISSN: 1552-5783</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.05-0266</identifier><identifier>PMID: 16186353</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Glaucoma - diagnosis ; Glaucoma and intraocular pressure ; Humans ; Medical sciences ; Ophthalmology ; Optic Disk - pathology ; Optic Nerve Diseases - diagnosis ; Vertebrates: nervous system and sense organs ; Vision Disorders - diagnosis ; Visual Field Tests - methods ; Visual Fields</subject><ispartof>Investigative ophthalmology & visual science, 2005-10, Vol.46 (10), p.3712-3717</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-fcbfb1681b6504fdffcbd0c731d07b1d85bfa5ebd42e20b0445f353887babf813</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17131241$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16186353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gardiner, Stuart K</creatorcontrib><creatorcontrib>Johnson, Chris A</creatorcontrib><creatorcontrib>Cioffi, George A</creatorcontrib><title>Evaluation of the Structure-Function Relationship in Glaucoma</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>While glaucoma is evaluated on the basis of structural and functional test results, the spatial relationship between structure and function is not well defined. This study produces a topographical map to demonstrate how sectors of the optic nerve head (ONH) are related to locations in the visual field, using empiric cross-sectional patient data.
One hundred nine subjects with healthy eyes and 166 subjects with diagnosed or suspected glaucoma (one test per patient) were evaluated using a retina tomograph and white-on-white standard automated perimetry (SAP). The tomograph ONH images were divided into 36 sectors; and the sector rim areas normalized to account for changes in the total rim area. These were then correlated with SAP thresholds. For each visual field location, a map was produced indicating the strength of correlation between the normalized sector rim areas and thresholds.
The highest correlation between a sector's normalized rim area and a SAP location's sensitivity was 0.520. Twenty-seven of the 52 non-blind spot SAP locations exhibited a correlation greater than 0.2 with at least one ONH sector. Locations in the superior hemifield were usually best correlated with the polar inferior temporal sectors of the ONH; locations in the inferior hemifield were usually best correlated with the polar superior temporal sectors of the ONH.
A map relating regions of the ONH to SAP test locations has been produced. This map may be useful in elucidating the structure-function relationship, particularly for cases of localized glaucomatous loss.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glaucoma - diagnosis</subject><subject>Glaucoma and intraocular pressure</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Ophthalmology</subject><subject>Optic Disk - pathology</subject><subject>Optic Nerve Diseases - diagnosis</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Vision Disorders - diagnosis</subject><subject>Visual Field Tests - methods</subject><subject>Visual Fields</subject><issn>0146-0404</issn><issn>1552-5783</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1r3DAQBmARGpJNmlvPxZcmlzqdkfV16SEs-SgEAm1zFpIsdVVkeyvZWfrvY2cXchrQPLwaXkI-IVwjCvktDi_lGngNVIgjskLOac2laj6QFSATNTBgp-SslL8AFJHCCTlFgUo0vFmR77cvJk1mjENfDaEaN776NebJjVP29d3Uu7fNT5_eSNnEbRX76j6ZyQ2d-UiOg0nFXxzmOXm-u_29fqgfn-5_rG8ea8dQjnVwNlgUCq3gwEIb5ocWnGywBWmxVdwGw71tGfUULDDGw3ydUtIaGxQ25-Ryn7vNw7_Jl1F3sTifkun9MBUtlKCSg5rh1z10eSgl-6C3OXYm_9cIeqlLL3Vp4Hqpa-afD7mT7Xz7jg_9zODLAZjiTArZ9C6WdyexQcqWA6_2bhP_bHYxe106k9Ici3q32zGx_N9IpM0rzVmBJg</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Gardiner, Stuart K</creator><creator>Johnson, Chris A</creator><creator>Cioffi, George A</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051001</creationdate><title>Evaluation of the Structure-Function Relationship in Glaucoma</title><author>Gardiner, Stuart K ; Johnson, Chris A ; Cioffi, George A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-fcbfb1681b6504fdffcbd0c731d07b1d85bfa5ebd42e20b0445f353887babf813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glaucoma - diagnosis</topic><topic>Glaucoma and intraocular pressure</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Ophthalmology</topic><topic>Optic Disk - pathology</topic><topic>Optic Nerve Diseases - diagnosis</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Vision Disorders - diagnosis</topic><topic>Visual Field Tests - methods</topic><topic>Visual Fields</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gardiner, Stuart K</creatorcontrib><creatorcontrib>Johnson, Chris A</creatorcontrib><creatorcontrib>Cioffi, George A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gardiner, Stuart K</au><au>Johnson, Chris A</au><au>Cioffi, George A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Structure-Function Relationship in Glaucoma</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>46</volume><issue>10</issue><spage>3712</spage><epage>3717</epage><pages>3712-3717</pages><issn>0146-0404</issn><issn>1552-5783</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>While glaucoma is evaluated on the basis of structural and functional test results, the spatial relationship between structure and function is not well defined. This study produces a topographical map to demonstrate how sectors of the optic nerve head (ONH) are related to locations in the visual field, using empiric cross-sectional patient data.
One hundred nine subjects with healthy eyes and 166 subjects with diagnosed or suspected glaucoma (one test per patient) were evaluated using a retina tomograph and white-on-white standard automated perimetry (SAP). The tomograph ONH images were divided into 36 sectors; and the sector rim areas normalized to account for changes in the total rim area. These were then correlated with SAP thresholds. For each visual field location, a map was produced indicating the strength of correlation between the normalized sector rim areas and thresholds.
The highest correlation between a sector's normalized rim area and a SAP location's sensitivity was 0.520. Twenty-seven of the 52 non-blind spot SAP locations exhibited a correlation greater than 0.2 with at least one ONH sector. Locations in the superior hemifield were usually best correlated with the polar inferior temporal sectors of the ONH; locations in the inferior hemifield were usually best correlated with the polar superior temporal sectors of the ONH.
A map relating regions of the ONH to SAP test locations has been produced. This map may be useful in elucidating the structure-function relationship, particularly for cases of localized glaucomatous loss.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>16186353</pmid><doi>10.1167/iovs.05-0266</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Aged, 80 and over Biological and medical sciences Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Glaucoma - diagnosis Glaucoma and intraocular pressure Humans Medical sciences Ophthalmology Optic Disk - pathology Optic Nerve Diseases - diagnosis Vertebrates: nervous system and sense organs Vision Disorders - diagnosis Visual Field Tests - methods Visual Fields |
| title | Evaluation of the Structure-Function Relationship in Glaucoma |
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