Removal of small nonenveloped viruses by antibody-enhanced nanofiltration during the manufacture of plasma derivatives

BACKGROUND: Filters with nominal pore sizes in the nanometer range are well‐established tools for enhancing the virus safety margins of plasma‐derived products, yet intrinsically less successful for smaller viruses such as hepatitis A virus (HAV) and human parvovirus B19 (B19V). The formation of vi...

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Veröffentlicht in:	Transfusion (Philadelphia, Pa.) Pa.), 2006-07, Vol.46 (7), p.1143-1151
Hauptverfasser:	Kreil, Thomas R., Wieser, Andreas, Berting, Andreas, Spruth, Martin, Medek, Christian, Pölsler, Gerhard, Gaida, Theodor, Hämmerle, Thomas, Teschner, Wolfgang, Schwarz, Hans Peter, Barrett, P. Noel
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antibodies, Viral Antigen-Antibody Complex Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Filtration - methods Hepatitis A Virus, Human - isolation & purification Human viral diseases Humans Infectious diseases Medical sciences Mice Minute Virus of Mice - isolation & purification Miscellaneous Nanostructures Parvovirus B19, Human - isolation & purification Plasma - virology Porosity Stomach, duodenum, intestine, rectum, anus Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Transfusions. Complications. Transfusion reactions. Cell and gene therapy Viral diseases Viruses - isolation & purification
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