Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells
We investigated the antiproliferative effects of four structurally similar prenylated xanthones, α-mangostin, β-mangostin, γ-mangostin, and methoxy-β-mangostin, in human colon cancer DLD-1 cells. We investigated the antiproliferative effects of four structurally similar prenylated xanthones, α-mango...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 2005-11, Vol.13 (21), p.6064-6069 |
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| creator | Matsumoto, Kenji Akao, Yukihiro Ohguchi, Kenji Ito, Tetsuro Tanaka, Toshiyuki Iinuma, Munekazu Nozawa, Yoshinori |
| description | We investigated the antiproliferative effects of four structurally similar prenylated xanthones, α-mangostin, β-mangostin, γ-mangostin, and methoxy-β-mangostin, in human colon cancer DLD-1 cells.
We investigated the antiproliferative effects of four structurally similar prenylated xanthones, α-mangostin, β-mangostin, γ-mangostin, and methoxy-β-mangostin, in human colon cancer DLD-1 cells. These xanthones differ in the number of hydroxyl and methoxy groups. Except for methoxy-β-mangostin, the other three xanthones strongly inhibited cell growth at 20
μM and their antitumor efficacy was correlated with the number of hydroxyl groups. Hoechst 33342 nuclear staining and nucleosomal DNA-gel electrophoresis revealed that the antiproliferative effects of α- and γ-mangostin, but not that of β-mangostin, were associated with apoptosis. It was also shown that their antiproliferative effects were associated with cell-cycle arrest by affecting the expression of cyclins, cdc2, and p27; G1 arrest was by α-mangostin and β-mangostin, and S arrest by γ-mangostin. These findings provide a relevant basis for the development of xanthones as an agent for cancer prevention and combination therapy with anti-cancer drugs. |
| doi_str_mv | 10.1016/j.bmc.2005.06.065 |
| format | Article |
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We investigated the antiproliferative effects of four structurally similar prenylated xanthones, α-mangostin, β-mangostin, γ-mangostin, and methoxy-β-mangostin, in human colon cancer DLD-1 cells. These xanthones differ in the number of hydroxyl and methoxy groups. Except for methoxy-β-mangostin, the other three xanthones strongly inhibited cell growth at 20
μM and their antitumor efficacy was correlated with the number of hydroxyl groups. Hoechst 33342 nuclear staining and nucleosomal DNA-gel electrophoresis revealed that the antiproliferative effects of α- and γ-mangostin, but not that of β-mangostin, were associated with apoptosis. It was also shown that their antiproliferative effects were associated with cell-cycle arrest by affecting the expression of cyclins, cdc2, and p27; G1 arrest was by α-mangostin and β-mangostin, and S arrest by γ-mangostin. These findings provide a relevant basis for the development of xanthones as an agent for cancer prevention and combination therapy with anti-cancer drugs.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmc.2005.06.065</identifier><identifier>PMID: 16112579</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anti-cancer ; Antineoplastic agents ; Apoptosis ; Apoptosis - drug effects ; Biological and medical sciences ; Cell Cycle - drug effects ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell-cycle arrest ; Colonic Neoplasms - pathology ; G1 Phase - drug effects ; General aspects ; Humans ; Medical sciences ; Molecular Structure ; Pharmacology. Drug treatments ; S Phase - drug effects ; Xanthone ; Xanthones - chemistry ; Xanthones - pharmacology</subject><ispartof>Bioorganic & medicinal chemistry, 2005-11, Vol.13 (21), p.6064-6069</ispartof><rights>2005 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-649df6da653d41a6604daea396f11f51c763fa6923847dd471a35007d6e8d143</citedby><cites>FETCH-LOGICAL-c381t-649df6da653d41a6604daea396f11f51c763fa6923847dd471a35007d6e8d143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0968089605006188$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17136366$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16112579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsumoto, Kenji</creatorcontrib><creatorcontrib>Akao, Yukihiro</creatorcontrib><creatorcontrib>Ohguchi, Kenji</creatorcontrib><creatorcontrib>Ito, Tetsuro</creatorcontrib><creatorcontrib>Tanaka, Toshiyuki</creatorcontrib><creatorcontrib>Iinuma, Munekazu</creatorcontrib><creatorcontrib>Nozawa, Yoshinori</creatorcontrib><title>Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>We investigated the antiproliferative effects of four structurally similar prenylated xanthones, α-mangostin, β-mangostin, γ-mangostin, and methoxy-β-mangostin, in human colon cancer DLD-1 cells.
We investigated the antiproliferative effects of four structurally similar prenylated xanthones, α-mangostin, β-mangostin, γ-mangostin, and methoxy-β-mangostin, in human colon cancer DLD-1 cells. These xanthones differ in the number of hydroxyl and methoxy groups. Except for methoxy-β-mangostin, the other three xanthones strongly inhibited cell growth at 20
μM and their antitumor efficacy was correlated with the number of hydroxyl groups. Hoechst 33342 nuclear staining and nucleosomal DNA-gel electrophoresis revealed that the antiproliferative effects of α- and γ-mangostin, but not that of β-mangostin, were associated with apoptosis. It was also shown that their antiproliferative effects were associated with cell-cycle arrest by affecting the expression of cyclins, cdc2, and p27; G1 arrest was by α-mangostin and β-mangostin, and S arrest by γ-mangostin. These findings provide a relevant basis for the development of xanthones as an agent for cancer prevention and combination therapy with anti-cancer drugs.</description><subject>Anti-cancer</subject><subject>Antineoplastic agents</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell-cycle arrest</subject><subject>Colonic Neoplasms - pathology</subject><subject>G1 Phase - drug effects</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Pharmacology. Drug treatments</subject><subject>S Phase - drug effects</subject><subject>Xanthone</subject><subject>Xanthones - chemistry</subject><subject>Xanthones - pharmacology</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtq5DAQRUWYkHQeHzCbwZuZnTsqSy5bZDXkDQ2BkEV2oiLJRI1tdSQ7kL8fdbohu4GianNucTmM_QS-BA54sV6-DmZZcV4vOeapD9gCJMpSCAU_2IIrbEveKjxmJymtOeeVVHDEjgEBqrpRC_b0QuP0FkaXCj_a2bjCuL4vzafpXUExujQVNNqCNmEzheS3WPE2DzQWJvQhbxqNi8X16rqEr2w6Y4cd9cmd7-8pe769eb66L1ePdw9Xf1elES1MJUplO7SEtbASCJFLS46Ewg6gq8E0KDpCVYlWNtbKBkjUnDcWXWtBilP2Z_d2E8P7nHvqwadtARpdmJPGFisUXGUQdqCJIaXoOr2JfqD4qYHrrUe91tmj3nrUHPPUOfNr_3x-HZz9TuzFZeD3HqBkqO9i1uDTN9eAQIGYucsd57KJD--iTsa7rMz66MykbfD_qfEPYxSOwQ</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>Matsumoto, Kenji</creator><creator>Akao, Yukihiro</creator><creator>Ohguchi, Kenji</creator><creator>Ito, Tetsuro</creator><creator>Tanaka, Toshiyuki</creator><creator>Iinuma, Munekazu</creator><creator>Nozawa, Yoshinori</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells</title><author>Matsumoto, Kenji ; Akao, Yukihiro ; Ohguchi, Kenji ; Ito, Tetsuro ; Tanaka, Toshiyuki ; Iinuma, Munekazu ; Nozawa, Yoshinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-649df6da653d41a6604daea396f11f51c763fa6923847dd471a35007d6e8d143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Anti-cancer</topic><topic>Antineoplastic agents</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cell Cycle - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell-cycle arrest</topic><topic>Colonic Neoplasms - pathology</topic><topic>G1 Phase - drug effects</topic><topic>General aspects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Pharmacology. Drug treatments</topic><topic>S Phase - drug effects</topic><topic>Xanthone</topic><topic>Xanthones - chemistry</topic><topic>Xanthones - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsumoto, Kenji</creatorcontrib><creatorcontrib>Akao, Yukihiro</creatorcontrib><creatorcontrib>Ohguchi, Kenji</creatorcontrib><creatorcontrib>Ito, Tetsuro</creatorcontrib><creatorcontrib>Tanaka, Toshiyuki</creatorcontrib><creatorcontrib>Iinuma, Munekazu</creatorcontrib><creatorcontrib>Nozawa, Yoshinori</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsumoto, Kenji</au><au>Akao, Yukihiro</au><au>Ohguchi, Kenji</au><au>Ito, Tetsuro</au><au>Tanaka, Toshiyuki</au><au>Iinuma, Munekazu</au><au>Nozawa, Yoshinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>13</volume><issue>21</issue><spage>6064</spage><epage>6069</epage><pages>6064-6069</pages><issn>0968-0896</issn><eissn>1464-3391</eissn><abstract>We investigated the antiproliferative effects of four structurally similar prenylated xanthones, α-mangostin, β-mangostin, γ-mangostin, and methoxy-β-mangostin, in human colon cancer DLD-1 cells.
We investigated the antiproliferative effects of four structurally similar prenylated xanthones, α-mangostin, β-mangostin, γ-mangostin, and methoxy-β-mangostin, in human colon cancer DLD-1 cells. These xanthones differ in the number of hydroxyl and methoxy groups. Except for methoxy-β-mangostin, the other three xanthones strongly inhibited cell growth at 20
μM and their antitumor efficacy was correlated with the number of hydroxyl groups. Hoechst 33342 nuclear staining and nucleosomal DNA-gel electrophoresis revealed that the antiproliferative effects of α- and γ-mangostin, but not that of β-mangostin, were associated with apoptosis. It was also shown that their antiproliferative effects were associated with cell-cycle arrest by affecting the expression of cyclins, cdc2, and p27; G1 arrest was by α-mangostin and β-mangostin, and S arrest by γ-mangostin. These findings provide a relevant basis for the development of xanthones as an agent for cancer prevention and combination therapy with anti-cancer drugs.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16112579</pmid><doi>10.1016/j.bmc.2005.06.065</doi><tpages>6</tpages></addata></record> |
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| subjects | Anti-cancer Antineoplastic agents Apoptosis Apoptosis - drug effects Biological and medical sciences Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cell-cycle arrest Colonic Neoplasms - pathology G1 Phase - drug effects General aspects Humans Medical sciences Molecular Structure Pharmacology. Drug treatments S Phase - drug effects Xanthone Xanthones - chemistry Xanthones - pharmacology |
| title | Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells |
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