p73-dependent induction of 14-3-3sigma increases the chemo-sensitivity of drug-resistant human breast cancers

It has been well documented that tumor suppressor p53 is mutated in about 50% of all human tumors. p53 status might be one of the critical determinants for the chemo-sensitivity of human tumors. In the present study, we have found that p53 family member p73 as well as 14-3-3sigma is down-regulated i...

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Veröffentlicht in:	Biochemical and biophysical research communications 2006-08, Vol.347 (1), p.327-333
Hauptverfasser:	Sang, Meixiang, Li, Yuanyuan, Ozaki, Toshinori, Ono, Sayaka, Ando, Kiyohiro, Yamamoto, Hideki, Koda, Tadayuki, Geng, Cuizhi, Nakagawara, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins Antibiotics, Antineoplastic - administration & dosage Biomarkers, Tumor Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Survival - drug effects DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Doxorubicin - administration & dosage Drug Resistance, Neoplasm Exonucleases Exoribonucleases Gene Expression Regulation, Neoplastic - drug effects Genes, Tumor Suppressor Humans Neoplasm Proteins Nuclear Proteins - metabolism Tumor Protein p73 Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Proteins
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