Human monocytoid cells as a model to study Toll-like receptor-mediated activation

THP-1 2A9, a subclone of the monocytoid cell line THP-1 and known to be exquisitely sensitive to LPS, was tested for TNF production following triggering by excess doses of TLR ligands. TLR2, TLR4 and TLR5 agonists, but neither TLR3 nor TLR9 agonists, induced TNF production. When used at lower concen...

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Veröffentlicht in:	Journal of immunological methods 2006-06, Vol.313 (1), p.1-10
Hauptverfasser:	Remer, Katharina A., Brcic, Marija, Sauter, Kay-Sara, Jungi, Thomas W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology Biological and medical sciences Calcitriol - pharmacology CD14 Cell Line Cysteine - analogs & derivatives Cysteine - pharmacology Flagellin - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression - drug effects Humans Interferon-gamma - pharmacology Lipopolysaccharide Receptors - genetics Lipopolysaccharides - pharmacology Lipoproteins - pharmacology Molecular immunology Monocytes - drug effects Monocytes - metabolism Monocytoid cells Peptidoglycan - pharmacology Poly I-C - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Techniques Teichoic Acids - pharmacology THP-1 TLR TLR agonists TNF Toll-Like Receptor 2 - agonists Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - immunology Toll-Like Receptor 3 - agonists Toll-Like Receptor 4 - agonists Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - immunology Toll-Like Receptor 5 - agonists Toll-Like Receptor 9 - agonists Toll-Like Receptors - agonists Toll-Like Receptors - physiology Tumor Necrosis Factor-alpha - metabolism
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