JNK Regulates MCP-1 Expression in Adenovirus Type 19-Infected Human Corneal Fibroblasts

Previous studies indicate that adenovirus type 19 (Ad19) infection of human corneal fibroblasts (HCFs) induces the expression of several proinflammatory mediators, including IL-8 and monocyte chemoattractant protein-1 (MCP-1), and that the tyrosine kinase c-Src and its downstream target, the mitogen...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2005-10, Vol.46 (10), p.3777-3782
Hauptverfasser:	Xiao, Jingnan, Chodosh, James
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses, Human - physiology Biological and medical sciences Cell Culture Techniques Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Cornea - metabolism Cornea - virology Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay Eye and associated structures. Visual pathways and centers. Vision Fibroblasts - metabolism Fibroblasts - virology Fundamental and applied biological sciences. Psychology Gene Expression Humans Immunoblotting JNK Mitogen-Activated Protein Kinases - physiology MAP Kinase Kinase 7 - metabolism Phosphorylation Polymerase Chain Reaction Proto-Oncogene Proteins c-jun - metabolism RNA, Messenger - metabolism Signal Transduction - physiology Vertebrates: nervous system and sense organs
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