8-isoprostaglandin E(2) activates Ca(2+)-dependent K(+) current via cyclic AMP signaling pathway in murine renal artery

The inhibitory pathway of 8-isoprostaglandin E(2) was investigated in murine renal arterial smooth muscle. K(+) current was augmented in a concentration-dependent fashion, with an average increase of 123+/-28% (n=6) following application of 10(-5) M 8-iso PGE(2). This augmentation was observed in th...

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Veröffentlicht in:	European journal of pharmacology 2005-09, Vol.520 (1-3), p.22-28
Hauptverfasser:	Zhang, Yongde, Pertens, Evi, Janssen, Luke J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Adenylyl Cyclase Inhibitors Animals Biological Factors Calcium - metabolism Cyclic AMP - metabolism Dinoprostone - analogs & derivatives Dinoprostone - pharmacology Dose-Response Relationship, Drug In Vitro Techniques Isoprostanes - pharmacology Membrane Potentials Mice Mice, Inbred BALB C Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Potassium - metabolism Potassium Channel Blockers - pharmacology Potassium Channels, Calcium-Activated - drug effects Potassium Channels, Calcium-Activated - metabolism Protein Kinase Inhibitors - pharmacology Renal Artery - drug effects Renal Artery - metabolism Signal Transduction
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