Polyketide stereotetrads in natural products

Natural products (or secondary metabolites) remain as the most important source for discovery of new and potential drug molecules. With high resolution data of their structures, and the advancement of synthesis possibilities, analysis of the natural products based on their specific structural featur...

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Veröffentlicht in:Chemical Society reviews 2005-08, Vol.34 (8), p.677-690
Hauptverfasser: Koskinen, Ari M P, Karisalmi, Kaisa
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Karisalmi, Kaisa
description Natural products (or secondary metabolites) remain as the most important source for discovery of new and potential drug molecules. With high resolution data of their structures, and the advancement of synthesis possibilities, analysis of the natural products based on their specific structural features is valuable to those entering the field. In this tutorial review we attempt such an analysis indicating the salient features of the structural classes with examples of the synthesis of each one of them. As the particular class of natural products, we have chosen polyketides.
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source Royal Society of Chemistry Journals Archive (1841-2007); MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Fatty Acids, Unsaturated - chemistry
Macrolides - chemical synthesis
Macrolides - chemistry
Molecular Conformation
Plant Extracts - chemistry
Stereoisomerism
title Polyketide stereotetrads in natural products
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