Evaluation of functional and binding assays in cells expressing either recombinant or endogenous hERG channel

Introduction: The hERG (human ether-a-go-go related gene) potassium channel is required for normal cardiac repolarization, is susceptible to inhibition by a wide variety of compounds, and its blockage can lead to cardiac QT interval prolongation and life threatening arrhythmias. The present report e...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmacological and toxicological methods 2006-07, Vol.54 (1), p.42-55
Hauptverfasser:	Murphy, Steven M., Palmer, Marc, Poole, Michelle Fontilla, Padegimas, Linas, Hunady, Karen, Danzig, Joel, Gill, Sikander, Gill, Rajwant, Ting, Anthony, Sherf, Bruce, Brunden, Kurt, Stricker-Krongrad, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	3H-dofetilide Animals Arrhythmias Binding assay Cell Line CHO Cells Cricetinae ERG1 Potassium Channel Ether-A-Go-Go Potassium Channels - biosynthesis Ether-A-Go-Go Potassium Channels - metabolism hERG Humans Membrane potential dye Protein Binding - physiology QT prolongation Radioligand Assay - methods Recombinant Proteins - biosynthesis Recombinant Proteins - metabolism Rubidium efflux Torsades de Pointes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!