Signalling mechanisms linking hepatic glucose and lipid metabolism
Fatty liver and hepatic triglyceride accumulation are strongly associated with obesity, insulin resistance and type 2 diabetes, and are subject to nutritional influences. Hepatic regulation of glucose and lipid homeostasis is influenced by a complex system of hormones, hormonally regulated signallin...
Gespeichert in:
| Veröffentlicht in: | Diabetologia 2006-08, Vol.49 (8), p.1732-1741 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1741 |
|---|---|
| container_issue | 8 |
| container_start_page | 1732 |
| container_title | Diabetologia |
| container_volume | 49 |
| creator | WEICKERT, M. O PFEIFFER, A. F. H |
| description | Fatty liver and hepatic triglyceride accumulation are strongly associated with obesity, insulin resistance and type 2 diabetes, and are subject to nutritional influences. Hepatic regulation of glucose and lipid homeostasis is influenced by a complex system of hormones, hormonally regulated signalling pathways and transcription factors. Recently, considerable progress has been made in elucidating molecular pathways and potential factors that are affected in insulin-resistant states. In this review we discuss some of the key factors that are involved in both the regulation of glucose and lipid metabolism in the liver. Understanding the molecular network that links hepatic lipid accumulation and impaired glucose metabolism may provide targets for dietary or pharmacological interventions. |
| doi_str_mv | 10.1007/s00125-006-0295-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68620708</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1075011171</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-d248d71631daaaf19ee447398dfba9980f23a6d92e3ed24b11c95d0a0ad318463</originalsourceid><addsrcrecordid>eNpd0E1LAzEQBuAgitbqD_AiRdDb6kySzSZHFb9A8KCCtzBNsu3W_aib7sF_b2oLgqeQzDPD5GXsBOESAYqrCIA8zwBUBtzkmdhhI5SCZyC53mWjdTlDrT4O2GGMCwAQuVT77ABVgVoqMWI3r9Wspbqu2tmkCW5ObRWbOEn3z_XTPCxpVbnJrB5cF8OEWp9qy8onvKJpVyd9xPZKqmM43p5j9n5_93b7mD2_PDzdXj9nThizyjyX2heoBHoiKtGEIGUhjPbllIzRUHJByhseREh2iuhM7oGAvPhddswuNnOXffc1hLiyTRVdqGtqQzdEq7TiUIBO8OwfXHRDn34ZLUehpUbJE8INcn0XYx9Ku-yrhvpvi2DX6dpNujala9fpWpF6TreDh2kT_F_HNs4EzreAoqO67Kl1VfxzhdGocyl-AJMfgW0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213848142</pqid></control><display><type>article</type><title>Signalling mechanisms linking hepatic glucose and lipid metabolism</title><source>MEDLINE</source><source>SpringerLink Journals (MCLS)</source><creator>WEICKERT, M. O ; PFEIFFER, A. F. H</creator><creatorcontrib>WEICKERT, M. O ; PFEIFFER, A. F. H</creatorcontrib><description>Fatty liver and hepatic triglyceride accumulation are strongly associated with obesity, insulin resistance and type 2 diabetes, and are subject to nutritional influences. Hepatic regulation of glucose and lipid homeostasis is influenced by a complex system of hormones, hormonally regulated signalling pathways and transcription factors. Recently, considerable progress has been made in elucidating molecular pathways and potential factors that are affected in insulin-resistant states. In this review we discuss some of the key factors that are involved in both the regulation of glucose and lipid metabolism in the liver. Understanding the molecular network that links hepatic lipid accumulation and impaired glucose metabolism may provide targets for dietary or pharmacological interventions.</description><identifier>ISSN: 0012-186X</identifier><identifier>EISSN: 1432-0428</identifier><identifier>DOI: 10.1007/s00125-006-0295-3</identifier><identifier>PMID: 16718463</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Biological and medical sciences ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes. Impaired glucose tolerance ; DNA-Binding Proteins - physiology ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty acids ; Fatty Liver - metabolism ; Gastroenterology. Liver. Pancreas. Abdomen ; Glucose ; Glucose - metabolism ; Homeostasis ; Humans ; Insulin resistance ; Kinases ; Lipids ; Lipids - physiology ; Liver ; Liver - metabolism ; Liver X Receptors ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Metabolism ; Metabolites ; Models, Biological ; Nutrition ; Obesity ; Orphan Nuclear Receptors ; Other diseases. Semiology ; Proteins ; Receptors, Cytoplasmic and Nuclear - physiology ; Signal Transduction - physiology ; Sterol Regulatory Element Binding Proteins - metabolism ; Transcription factors ; Triglycerides - metabolism</subject><ispartof>Diabetologia, 2006-08, Vol.49 (8), p.1732-1741</ispartof><rights>2006 INIST-CNRS</rights><rights>Springer-Verlag 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-d248d71631daaaf19ee447398dfba9980f23a6d92e3ed24b11c95d0a0ad318463</citedby><cites>FETCH-LOGICAL-c399t-d248d71631daaaf19ee447398dfba9980f23a6d92e3ed24b11c95d0a0ad318463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17981854$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16718463$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WEICKERT, M. O</creatorcontrib><creatorcontrib>PFEIFFER, A. F. H</creatorcontrib><title>Signalling mechanisms linking hepatic glucose and lipid metabolism</title><title>Diabetologia</title><addtitle>Diabetologia</addtitle><description>Fatty liver and hepatic triglyceride accumulation are strongly associated with obesity, insulin resistance and type 2 diabetes, and are subject to nutritional influences. Hepatic regulation of glucose and lipid homeostasis is influenced by a complex system of hormones, hormonally regulated signalling pathways and transcription factors. Recently, considerable progress has been made in elucidating molecular pathways and potential factors that are affected in insulin-resistant states. In this review we discuss some of the key factors that are involved in both the regulation of glucose and lipid metabolism in the liver. Understanding the molecular network that links hepatic lipid accumulation and impaired glucose metabolism may provide targets for dietary or pharmacological interventions.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>DNA-Binding Proteins - physiology</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fatty acids</subject><subject>Fatty Liver - metabolism</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Kinases</subject><subject>Lipids</subject><subject>Lipids - physiology</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Liver X Receptors</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Models, Biological</subject><subject>Nutrition</subject><subject>Obesity</subject><subject>Orphan Nuclear Receptors</subject><subject>Other diseases. Semiology</subject><subject>Proteins</subject><subject>Receptors, Cytoplasmic and Nuclear - physiology</subject><subject>Signal Transduction - physiology</subject><subject>Sterol Regulatory Element Binding Proteins - metabolism</subject><subject>Transcription factors</subject><subject>Triglycerides - metabolism</subject><issn>0012-186X</issn><issn>1432-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0E1LAzEQBuAgitbqD_AiRdDb6kySzSZHFb9A8KCCtzBNsu3W_aib7sF_b2oLgqeQzDPD5GXsBOESAYqrCIA8zwBUBtzkmdhhI5SCZyC53mWjdTlDrT4O2GGMCwAQuVT77ABVgVoqMWI3r9Wspbqu2tmkCW5ObRWbOEn3z_XTPCxpVbnJrB5cF8OEWp9qy8onvKJpVyd9xPZKqmM43p5j9n5_93b7mD2_PDzdXj9nThizyjyX2heoBHoiKtGEIGUhjPbllIzRUHJByhseREh2iuhM7oGAvPhddswuNnOXffc1hLiyTRVdqGtqQzdEq7TiUIBO8OwfXHRDn34ZLUehpUbJE8INcn0XYx9Ku-yrhvpvi2DX6dpNujala9fpWpF6TreDh2kT_F_HNs4EzreAoqO67Kl1VfxzhdGocyl-AJMfgW0</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>WEICKERT, M. O</creator><creator>PFEIFFER, A. F. H</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>Signalling mechanisms linking hepatic glucose and lipid metabolism</title><author>WEICKERT, M. O ; PFEIFFER, A. F. H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-d248d71631daaaf19ee447398dfba9980f23a6d92e3ed24b11c95d0a0ad318463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>DNA-Binding Proteins - physiology</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fatty acids</topic><topic>Fatty Liver - metabolism</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Glucose</topic><topic>Glucose - metabolism</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Kinases</topic><topic>Lipids</topic><topic>Lipids - physiology</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Liver X Receptors</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Models, Biological</topic><topic>Nutrition</topic><topic>Obesity</topic><topic>Orphan Nuclear Receptors</topic><topic>Other diseases. Semiology</topic><topic>Proteins</topic><topic>Receptors, Cytoplasmic and Nuclear - physiology</topic><topic>Signal Transduction - physiology</topic><topic>Sterol Regulatory Element Binding Proteins - metabolism</topic><topic>Transcription factors</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WEICKERT, M. O</creatorcontrib><creatorcontrib>PFEIFFER, A. F. H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WEICKERT, M. O</au><au>PFEIFFER, A. F. H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Signalling mechanisms linking hepatic glucose and lipid metabolism</atitle><jtitle>Diabetologia</jtitle><addtitle>Diabetologia</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>49</volume><issue>8</issue><spage>1732</spage><epage>1741</epage><pages>1732-1741</pages><issn>0012-186X</issn><eissn>1432-0428</eissn><abstract>Fatty liver and hepatic triglyceride accumulation are strongly associated with obesity, insulin resistance and type 2 diabetes, and are subject to nutritional influences. Hepatic regulation of glucose and lipid homeostasis is influenced by a complex system of hormones, hormonally regulated signalling pathways and transcription factors. Recently, considerable progress has been made in elucidating molecular pathways and potential factors that are affected in insulin-resistant states. In this review we discuss some of the key factors that are involved in both the regulation of glucose and lipid metabolism in the liver. Understanding the molecular network that links hepatic lipid accumulation and impaired glucose metabolism may provide targets for dietary or pharmacological interventions.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>16718463</pmid><doi>10.1007/s00125-006-0295-3</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-186X |
| ispartof | Diabetologia, 2006-08, Vol.49 (8), p.1732-1741 |
| issn | 0012-186X 1432-0428 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68620708 |
| source | MEDLINE; SpringerLink Journals (MCLS) |
| subjects | Animals Biological and medical sciences Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance DNA-Binding Proteins - physiology Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fatty acids Fatty Liver - metabolism Gastroenterology. Liver. Pancreas. Abdomen Glucose Glucose - metabolism Homeostasis Humans Insulin resistance Kinases Lipids Lipids - physiology Liver Liver - metabolism Liver X Receptors Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Metabolism Metabolites Models, Biological Nutrition Obesity Orphan Nuclear Receptors Other diseases. Semiology Proteins Receptors, Cytoplasmic and Nuclear - physiology Signal Transduction - physiology Sterol Regulatory Element Binding Proteins - metabolism Transcription factors Triglycerides - metabolism |
| title | Signalling mechanisms linking hepatic glucose and lipid metabolism |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T06%3A43%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Signalling%20mechanisms%20linking%20hepatic%20glucose%20and%20lipid%20metabolism&rft.jtitle=Diabetologia&rft.au=WEICKERT,%20M.%20O&rft.date=2006-08-01&rft.volume=49&rft.issue=8&rft.spage=1732&rft.epage=1741&rft.pages=1732-1741&rft.issn=0012-186X&rft.eissn=1432-0428&rft_id=info:doi/10.1007/s00125-006-0295-3&rft_dat=%3Cproquest_cross%3E1075011171%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213848142&rft_id=info:pmid/16718463&rfr_iscdi=true |