Multi-residue liquid chromatography/tandem mass spectrometric analysis of beta-agonists in urine using molecular imprinted polymers
Ion suppression, a matrix effect that affects quantitative mass spectrometry, is one of the main problems encountered in liquid chromatography/tandem mass spectrometry. Two different clean‐up steps for the multi‐residue analysis of beta‐agonists in urine were evaluated with respect to minimisation o...
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| Veröffentlicht in: | Rapid communications in mass spectrometry 2005-01, Vol.19 (19), p.2801-2808 |
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| container_title | Rapid communications in mass spectrometry |
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| creator | Van Hoof, Nathalie Courtheyn, Dirk Antignac, Jean-Philippe Van de Wiele, Mieke Poelmans, Sofie Noppe, Herlinde De Brabander, Hubert |
| description | Ion suppression, a matrix effect that affects quantitative mass spectrometry, is one of the main problems encountered in liquid chromatography/tandem mass spectrometry. Two different clean‐up steps for the multi‐residue analysis of beta‐agonists in urine were evaluated with respect to minimisation of ion suppression, namely, a mixed‐phase solid phase extraction (SPE) column, i.e., clean screen Dau (CSD), and a molecular imprinted polymer (MIP) SPE column. Ion suppression experiments revealed that CSD sample clean‐up can lead to false negative results for some beta‐agonists, and that clean‐up using MIP columns is more selective for beta‐agonists than the use of CSD columns. Copyright © 2005 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/rcm.2126 |
| format | Article |
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Mass Spectrom</addtitle><description>Ion suppression, a matrix effect that affects quantitative mass spectrometry, is one of the main problems encountered in liquid chromatography/tandem mass spectrometry. Two different clean‐up steps for the multi‐residue analysis of beta‐agonists in urine were evaluated with respect to minimisation of ion suppression, namely, a mixed‐phase solid phase extraction (SPE) column, i.e., clean screen Dau (CSD), and a molecular imprinted polymer (MIP) SPE column. Ion suppression experiments revealed that CSD sample clean‐up can lead to false negative results for some beta‐agonists, and that clean‐up using MIP columns is more selective for beta‐agonists than the use of CSD columns. Copyright © 2005 John Wiley & Sons, Ltd.</description><subject>Adrenergic beta-Agonists - urine</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>False Negative Reactions</subject><subject>Polymers</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Spectrometry, Mass, Electrospray Ionization - methods</subject><subject>Surface Properties</subject><issn>0951-4198</issn><issn>1097-0231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kFFr1TAUgIM43HUK_gLJk_jSLUnbpH3Uy7wKdwq6IewlpMnpXTRpuqRB--wft-OW-eTTgXM-Pg4fQq8oOaeEsIuo_TmjjD9BG0paURBW0qdoQ9qaFhVtm1P0PKUfhFBaM_IMnVJOq5pXYoP-XGU32SJCsiYDdvY-W4P1XQxeTeEQ1Xg3X0xqMOCxVynhNIKelitM0WqsBuXmZBMOPe5gUoU6hMGmKWE74BztADgnOxywDw50dipi68dlP4HBY3Czh5heoJNeuQQv13mGbj5cXm8_Fvsvu0_bd_tCV6zkRSOgokZ3nTIl9Fzwvq4Y6VhT1oo2xhjW1SBELxTpK8EU9D2wtgNNoeQc2vIMvTl6xxjuM6RJeps0OKcGCDlJ3nBGOBEL-PYI6hhSitDL5WWv4iwpkQ_B5RJcPgRf0NerM3cezD9wLbwAxRH4ZR3M_xXJr9urVbjyS0X4_cir-FNyUYpafv-8k7fV_v03eruTpPwLmRudsw</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>Van Hoof, Nathalie</creator><creator>Courtheyn, Dirk</creator><creator>Antignac, Jean-Philippe</creator><creator>Van de Wiele, Mieke</creator><creator>Poelmans, Sofie</creator><creator>Noppe, Herlinde</creator><creator>De Brabander, Hubert</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050101</creationdate><title>Multi-residue liquid chromatography/tandem mass spectrometric analysis of beta-agonists in urine using molecular imprinted polymers</title><author>Van Hoof, Nathalie ; Courtheyn, Dirk ; Antignac, Jean-Philippe ; Van de Wiele, Mieke ; Poelmans, Sofie ; Noppe, Herlinde ; De Brabander, Hubert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4236-87e41dcbbad3ef676f5420b2835a18ddd2b5e77f7a0f472aeffe29bec1e366e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adrenergic beta-Agonists - urine</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>False Negative Reactions</topic><topic>Polymers</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Spectrometry, Mass, Electrospray Ionization - methods</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Hoof, Nathalie</creatorcontrib><creatorcontrib>Courtheyn, Dirk</creatorcontrib><creatorcontrib>Antignac, Jean-Philippe</creatorcontrib><creatorcontrib>Van de Wiele, Mieke</creatorcontrib><creatorcontrib>Poelmans, Sofie</creatorcontrib><creatorcontrib>Noppe, Herlinde</creatorcontrib><creatorcontrib>De Brabander, Hubert</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Rapid communications in mass spectrometry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Hoof, Nathalie</au><au>Courtheyn, Dirk</au><au>Antignac, Jean-Philippe</au><au>Van de Wiele, Mieke</au><au>Poelmans, Sofie</au><au>Noppe, Herlinde</au><au>De Brabander, Hubert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multi-residue liquid chromatography/tandem mass spectrometric analysis of beta-agonists in urine using molecular imprinted polymers</atitle><jtitle>Rapid communications in mass spectrometry</jtitle><addtitle>Rapid Commun. Mass Spectrom</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>19</volume><issue>19</issue><spage>2801</spage><epage>2808</epage><pages>2801-2808</pages><issn>0951-4198</issn><eissn>1097-0231</eissn><abstract>Ion suppression, a matrix effect that affects quantitative mass spectrometry, is one of the main problems encountered in liquid chromatography/tandem mass spectrometry. Two different clean‐up steps for the multi‐residue analysis of beta‐agonists in urine were evaluated with respect to minimisation of ion suppression, namely, a mixed‐phase solid phase extraction (SPE) column, i.e., clean screen Dau (CSD), and a molecular imprinted polymer (MIP) SPE column. Ion suppression experiments revealed that CSD sample clean‐up can lead to false negative results for some beta‐agonists, and that clean‐up using MIP columns is more selective for beta‐agonists than the use of CSD columns. Copyright © 2005 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>16145647</pmid><doi>10.1002/rcm.2126</doi><tpages>8</tpages></addata></record> |
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| ispartof | Rapid communications in mass spectrometry, 2005-01, Vol.19 (19), p.2801-2808 |
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| subjects | Adrenergic beta-Agonists - urine Chromatography, High Pressure Liquid - methods False Negative Reactions Polymers Reproducibility of Results Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods Surface Properties |
| title | Multi-residue liquid chromatography/tandem mass spectrometric analysis of beta-agonists in urine using molecular imprinted polymers |
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