Sesquiterpenoid Metabolites with Antiplasmodial Activity from a Caribbean Gorgonian Coral, Eunicea sp
A chemical investigation of the Caribbean gorgonian octocoral Eunicea sp. collected along the northwest coast of Puerto Rico has afforded seven new secondary metabolites, 1−7, belonging to several types of sesquiterpenes, including elemane, eudesmane, and germacrane types, along with the known stero...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2005-09, Vol.68 (9), p.1354-1359 |
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| container_issue | 9 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | GARZON, Sandra P RODRIGUEZ, Abimael D SANCHEZ, Juan A ORTEGA-BARRIA, Eduardo |
| description | A chemical investigation of the Caribbean gorgonian octocoral Eunicea sp. collected along the northwest coast of Puerto Rico has afforded seven new secondary metabolites, 1−7, belonging to several types of sesquiterpenes, including elemane, eudesmane, and germacrane types, along with the known steroidal glycoside 8. Some of the new metabolites, 4−7, carry an unusual ester side chain at the C-6 position. The structures of all compounds, including their relative stereochemistry, were determined by combined spectroscopic methods. The present compounds exhibited a significant inhibitory effect upon the growth of the malarial parasite Plasmodium falciparum. |
| doi_str_mv | 10.1021/np0501684 |
| format | Article |
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Some of the new metabolites, 4−7, carry an unusual ester side chain at the C-6 position. The structures of all compounds, including their relative stereochemistry, were determined by combined spectroscopic methods. The present compounds exhibited a significant inhibitory effect upon the growth of the malarial parasite Plasmodium falciparum.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np0501684</identifier><identifier>PMID: 16180813</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Animals ; Anthozoa - chemistry ; Antimalarials - chemistry ; Antimalarials - isolation & purification ; Antimalarials - pharmacology ; Biological and medical sciences ; Eunicea ; General pharmacology ; Gorgonacea ; Medical sciences ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Pharmacognosy. Homeopathy. 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Nat. Prod</addtitle><description>A chemical investigation of the Caribbean gorgonian octocoral Eunicea sp. collected along the northwest coast of Puerto Rico has afforded seven new secondary metabolites, 1−7, belonging to several types of sesquiterpenes, including elemane, eudesmane, and germacrane types, along with the known steroidal glycoside 8. Some of the new metabolites, 4−7, carry an unusual ester side chain at the C-6 position. The structures of all compounds, including their relative stereochemistry, were determined by combined spectroscopic methods. The present compounds exhibited a significant inhibitory effect upon the growth of the malarial parasite Plasmodium falciparum.</description><subject>Animals</subject><subject>Anthozoa - chemistry</subject><subject>Antimalarials - chemistry</subject><subject>Antimalarials - isolation & purification</subject><subject>Antimalarials - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Eunicea</subject><subject>General pharmacology</subject><subject>Gorgonacea</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Nuclear Magnetic Resonance, Biomolecular</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasmodium falciparum</subject><subject>Plasmodium falciparum - drug effects</subject><subject>Puerto Rico</subject><subject>Sesquiterpenes - chemistry</subject><subject>Sesquiterpenes - isolation & purification</subject><subject>Sesquiterpenes - pharmacology</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0Mtu1DAUBmALgehQWPACyBuQkAjYTuLLcjQqA2W4SC3q0jpJTsAlsVM7Afr2GM2os0FiZev40y-fn5CnnL3mTPA3fmI141JX98iK14IVkon6PlnlWVmUWlYn5FFK14yxkpn6ITnhkmumebkieIHpZnEzxgl9cB39iDM0YciTRH-5-Ttd-9lNA6QxdA4Gum5n99PNt7SPYaRANxBd0yB4ug3xW_Au3zYhwvCKni3etQg0TY_Jgx6GhE8O5yn5-vbscvOu2H3evt-sdwVUXMwFr6U0paorpsB0reISUXW1MkwpJRoUva44A2OEMKLh2EDFKlMpiQ3roC_LU_JinzvFcLNgmu3oUovDAB7DkqzUeXGp5H8hN0KbUtcZvtzDNoaUIvZ2im6EeGs5s3_Lt3flZ_vsELo0I3ZHeWg7g-cHAKmFoY_gW5eOTvFKs1pnV-ydSzP-vnuH-MNKlfuxl18ubHm1-7C9-nRuz4-50CZ7HZboc8n_-OAfTa6mTw</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>GARZON, Sandra P</creator><creator>RODRIGUEZ, Abimael D</creator><creator>SANCHEZ, Juan A</creator><creator>ORTEGA-BARRIA, Eduardo</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Sesquiterpenoid Metabolites with Antiplasmodial Activity from a Caribbean Gorgonian Coral, Eunicea sp</title><author>GARZON, Sandra P ; RODRIGUEZ, Abimael D ; SANCHEZ, Juan A ; ORTEGA-BARRIA, Eduardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a412t-15669375407a9dc716ee7d57907772be2f8410a992292b1eba4049476eb0daf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Anthozoa - chemistry</topic><topic>Antimalarials - chemistry</topic><topic>Antimalarials - isolation & purification</topic><topic>Antimalarials - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Eunicea</topic><topic>General pharmacology</topic><topic>Gorgonacea</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Nuclear Magnetic Resonance, Biomolecular</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plasmodium falciparum</topic><topic>Plasmodium falciparum - drug effects</topic><topic>Puerto Rico</topic><topic>Sesquiterpenes - chemistry</topic><topic>Sesquiterpenes - isolation & purification</topic><topic>Sesquiterpenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GARZON, Sandra P</creatorcontrib><creatorcontrib>RODRIGUEZ, Abimael D</creatorcontrib><creatorcontrib>SANCHEZ, Juan A</creatorcontrib><creatorcontrib>ORTEGA-BARRIA, Eduardo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GARZON, Sandra P</au><au>RODRIGUEZ, Abimael D</au><au>SANCHEZ, Juan A</au><au>ORTEGA-BARRIA, Eduardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sesquiterpenoid Metabolites with Antiplasmodial Activity from a Caribbean Gorgonian Coral, Eunicea sp</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>68</volume><issue>9</issue><spage>1354</spage><epage>1359</epage><pages>1354-1359</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>A chemical investigation of the Caribbean gorgonian octocoral Eunicea sp. collected along the northwest coast of Puerto Rico has afforded seven new secondary metabolites, 1−7, belonging to several types of sesquiterpenes, including elemane, eudesmane, and germacrane types, along with the known steroidal glycoside 8. Some of the new metabolites, 4−7, carry an unusual ester side chain at the C-6 position. The structures of all compounds, including their relative stereochemistry, were determined by combined spectroscopic methods. The present compounds exhibited a significant inhibitory effect upon the growth of the malarial parasite Plasmodium falciparum.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>16180813</pmid><doi>10.1021/np0501684</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of natural products (Washington, D.C.), 2005-09, Vol.68 (9), p.1354-1359 |
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| subjects | Animals Anthozoa - chemistry Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Biological and medical sciences Eunicea General pharmacology Gorgonacea Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plasmodium falciparum Plasmodium falciparum - drug effects Puerto Rico Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology |
| title | Sesquiterpenoid Metabolites with Antiplasmodial Activity from a Caribbean Gorgonian Coral, Eunicea sp |
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