Spontaneously acquired haemophilia: report of a patient with prostatic adenoma
We report the case of a 86-year-old man admitted in a local hospital with spontaneous haematoma, an isolated prolonged activated partial prothrombin time (114/32 seconds; ratio = 3.6), an anemia and a normal platelet count. Two diagnosis were suspected: a coagulation factor defect, or the presence o...
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| Veröffentlicht in: | Annales de biologie clinique (Paris) 2006-07, Vol.64 (4), p.347-352 |
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| container_title | Annales de biologie clinique (Paris) |
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| creator | Barrier, F de La Guerenne, A Semjen, E Wierre, L Horrent, S Decaudin, B Resibois, J P Weillaert, M P Azar, R Odou, P |
| description | We report the case of a 86-year-old man admitted in a local hospital with spontaneous haematoma, an isolated prolonged activated partial prothrombin time (114/32 seconds; ratio = 3.6), an anemia and a normal platelet count. Two diagnosis were suspected: a coagulation factor defect, or the presence of a lupus anticoagulant or of anti-factor antibodies. An acquired haemophilia A was confirmed with a factor VIII activity level < 1 U/dL associated with the presence of an anti-factor VIII inhibitor. The factor VIII inhibitor titer reached 195 Bethesda U/mL. A prostatic adenocarcinoma was suspected: a 5 cm prostatic tumour was found and the PSA level was 113 ng/mL. The patient was treated with recombinant factor VIIa: Novoseven (90 microg/kg). None immunosuppressive agents were prescribed in this elderly patient. The patient's disease was identified as a spontaneously acquired haemophilia A associated with prostatic adenocarcinoma. |
| format | Article |
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Two diagnosis were suspected: a coagulation factor defect, or the presence of a lupus anticoagulant or of anti-factor antibodies. An acquired haemophilia A was confirmed with a factor VIII activity level < 1 U/dL associated with the presence of an anti-factor VIII inhibitor. The factor VIII inhibitor titer reached 195 Bethesda U/mL. A prostatic adenocarcinoma was suspected: a 5 cm prostatic tumour was found and the PSA level was 113 ng/mL. The patient was treated with recombinant factor VIIa: Novoseven (90 microg/kg). None immunosuppressive agents were prescribed in this elderly patient. The patient's disease was identified as a spontaneously acquired haemophilia A associated with prostatic adenocarcinoma.</description><identifier>ISSN: 0003-3898</identifier><identifier>PMID: 16829479</identifier><language>fre</language><publisher>France</publisher><subject>Adenoma - complications ; Aged, 80 and over ; Anemia - etiology ; Diagnosis, Differential ; Factor VIII - analysis ; Hematoma ; Hemophilia A - diagnosis ; Hemophilia A - etiology ; Humans ; Male ; Prostate-Specific Antigen - blood ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - complications ; Triazines</subject><ispartof>Annales de biologie clinique (Paris), 2006-07, Vol.64 (4), p.347-352</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16829479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barrier, F</creatorcontrib><creatorcontrib>de La Guerenne, A</creatorcontrib><creatorcontrib>Semjen, E</creatorcontrib><creatorcontrib>Wierre, L</creatorcontrib><creatorcontrib>Horrent, S</creatorcontrib><creatorcontrib>Decaudin, B</creatorcontrib><creatorcontrib>Resibois, J P</creatorcontrib><creatorcontrib>Weillaert, M P</creatorcontrib><creatorcontrib>Azar, R</creatorcontrib><creatorcontrib>Odou, P</creatorcontrib><title>Spontaneously acquired haemophilia: report of a patient with prostatic adenoma</title><title>Annales de biologie clinique (Paris)</title><addtitle>Ann Biol Clin (Paris)</addtitle><description>We report the case of a 86-year-old man admitted in a local hospital with spontaneous haematoma, an isolated prolonged activated partial prothrombin time (114/32 seconds; ratio = 3.6), an anemia and a normal platelet count. Two diagnosis were suspected: a coagulation factor defect, or the presence of a lupus anticoagulant or of anti-factor antibodies. An acquired haemophilia A was confirmed with a factor VIII activity level < 1 U/dL associated with the presence of an anti-factor VIII inhibitor. The factor VIII inhibitor titer reached 195 Bethesda U/mL. A prostatic adenocarcinoma was suspected: a 5 cm prostatic tumour was found and the PSA level was 113 ng/mL. The patient was treated with recombinant factor VIIa: Novoseven (90 microg/kg). None immunosuppressive agents were prescribed in this elderly patient. The patient's disease was identified as a spontaneously acquired haemophilia A associated with prostatic adenocarcinoma.</description><subject>Adenoma - complications</subject><subject>Aged, 80 and over</subject><subject>Anemia - etiology</subject><subject>Diagnosis, Differential</subject><subject>Factor VIII - analysis</subject><subject>Hematoma</subject><subject>Hemophilia A - diagnosis</subject><subject>Hemophilia A - etiology</subject><subject>Humans</subject><subject>Male</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - complications</subject><subject>Triazines</subject><issn>0003-3898</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtLxDAcxHNQ3HX1K0hO3gp5tGniTRZfsOhBPZc8_mUjbZNNUmS_vYVdTwPDj2FmLtCaEMIrLpVcoeucfwihTHJ-hVZUSKbqVq3R-2cMU9EThDkPR6ztYfYJHN5rGEPc-8HrB5wghlRw6LHGURcPU8G_vuxxTCGXxbBYO5jCqG_QZa-HDLdn3aDv56ev7Wu1-3h52z7uqki5KlUjpAFgYBrWQy25I7zltKHSEmd7aSi0ygkDTApdG2rcAhJKrHW6ZdxSvkH3p9ylwWGGXLrRZwvDcFrSCSloy1W9gHdncDYjuC4mP-p07P4f4H_ihFgB</recordid><startdate>200607</startdate><enddate>200607</enddate><creator>Barrier, F</creator><creator>de La Guerenne, A</creator><creator>Semjen, E</creator><creator>Wierre, L</creator><creator>Horrent, S</creator><creator>Decaudin, B</creator><creator>Resibois, J P</creator><creator>Weillaert, M P</creator><creator>Azar, R</creator><creator>Odou, P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200607</creationdate><title>Spontaneously acquired haemophilia: report of a patient with prostatic adenoma</title><author>Barrier, F ; de La Guerenne, A ; Semjen, E ; Wierre, L ; Horrent, S ; Decaudin, B ; Resibois, J P ; Weillaert, M P ; Azar, R ; Odou, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-568bee2eb52fe483d03731518c0dcf8b1e79d6be286a4b1bdb52010ccda723c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2006</creationdate><topic>Adenoma - complications</topic><topic>Aged, 80 and over</topic><topic>Anemia - etiology</topic><topic>Diagnosis, Differential</topic><topic>Factor VIII - analysis</topic><topic>Hematoma</topic><topic>Hemophilia A - diagnosis</topic><topic>Hemophilia A - etiology</topic><topic>Humans</topic><topic>Male</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - complications</topic><topic>Triazines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barrier, F</creatorcontrib><creatorcontrib>de La Guerenne, A</creatorcontrib><creatorcontrib>Semjen, E</creatorcontrib><creatorcontrib>Wierre, L</creatorcontrib><creatorcontrib>Horrent, S</creatorcontrib><creatorcontrib>Decaudin, B</creatorcontrib><creatorcontrib>Resibois, J P</creatorcontrib><creatorcontrib>Weillaert, M P</creatorcontrib><creatorcontrib>Azar, R</creatorcontrib><creatorcontrib>Odou, P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Annales de biologie clinique (Paris)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barrier, F</au><au>de La Guerenne, A</au><au>Semjen, E</au><au>Wierre, L</au><au>Horrent, S</au><au>Decaudin, B</au><au>Resibois, J P</au><au>Weillaert, M P</au><au>Azar, R</au><au>Odou, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneously acquired haemophilia: report of a patient with prostatic adenoma</atitle><jtitle>Annales de biologie clinique (Paris)</jtitle><addtitle>Ann Biol Clin (Paris)</addtitle><date>2006-07</date><risdate>2006</risdate><volume>64</volume><issue>4</issue><spage>347</spage><epage>352</epage><pages>347-352</pages><issn>0003-3898</issn><abstract>We report the case of a 86-year-old man admitted in a local hospital with spontaneous haematoma, an isolated prolonged activated partial prothrombin time (114/32 seconds; ratio = 3.6), an anemia and a normal platelet count. Two diagnosis were suspected: a coagulation factor defect, or the presence of a lupus anticoagulant or of anti-factor antibodies. An acquired haemophilia A was confirmed with a factor VIII activity level < 1 U/dL associated with the presence of an anti-factor VIII inhibitor. The factor VIII inhibitor titer reached 195 Bethesda U/mL. A prostatic adenocarcinoma was suspected: a 5 cm prostatic tumour was found and the PSA level was 113 ng/mL. The patient was treated with recombinant factor VIIa: Novoseven (90 microg/kg). None immunosuppressive agents were prescribed in this elderly patient. The patient's disease was identified as a spontaneously acquired haemophilia A associated with prostatic adenocarcinoma.</abstract><cop>France</cop><pmid>16829479</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Annales de biologie clinique (Paris), 2006-07, Vol.64 (4), p.347-352 |
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| language | fre |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adenoma - complications Aged, 80 and over Anemia - etiology Diagnosis, Differential Factor VIII - analysis Hematoma Hemophilia A - diagnosis Hemophilia A - etiology Humans Male Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - complications Triazines |
| title | Spontaneously acquired haemophilia: report of a patient with prostatic adenoma |
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