Decreased sepsis related to indwelling venous access devices coincident with implementation of universal leukoreduction of blood transfusions
BACKGROUND: Randomized trials and animal models demonstrate that leukoreduction of transfusions can reduce the risk of post‐operative infections. We performed a retrospective study of sepsis related to indwelling venous access devices (line related infections) before and after the July 2000 implemen...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2005-10, Vol.45 (10), p.1632-1639 |
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| creator | Blumberg, Neil Fine, Lynn Gettings, Kelly F. Heal, Joanna M. |
| description | BACKGROUND: Randomized trials and animal models demonstrate that leukoreduction of transfusions can reduce the risk of post‐operative infections. We performed a retrospective study of sepsis related to indwelling venous access devices (line related infections) before and after the July 2000 implementation of universal leukoreduction.
METHODS: Line related infection data were collected from hospital infection control records for an 18‐month period before and after July 2000. Transfusion histories were obtained from transfusion service records.
RESULTS: Line related infections decreased in number from 150 to 98 (−35%) in transfused patients after implementation of universal leukoreduction, whereas line related infections increased from 41 to 45 (+10%) in nontransfused patients (p = 0.04). This corresponded to a decrease from 5.3 to 3.3 infections/10,000 patient days in transfused patients (p = 0.002). The infection rate remained stable in nontransfused patients at 1.5 infections/10,000 patient days both pre‐ and postimplementation of universal leukoreduction. Quantitatively similar decreases (33–45%) were seen in transfused surgical, medical and pediatric patients.
CONCLUSIONs: A substantial and statistically significant decrease in line related infections occurred coincident with implementation of universal leukore‐duction. These improved outcomes were observed in transfused but not nontransfused patients, across all clinical services, suggesting a causal relationship with universal leukoreduction. |
| doi_str_mv | 10.1111/j.1537-2995.2005.00565.x |
| format | Article |
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METHODS: Line related infection data were collected from hospital infection control records for an 18‐month period before and after July 2000. Transfusion histories were obtained from transfusion service records.
RESULTS: Line related infections decreased in number from 150 to 98 (−35%) in transfused patients after implementation of universal leukoreduction, whereas line related infections increased from 41 to 45 (+10%) in nontransfused patients (p = 0.04). This corresponded to a decrease from 5.3 to 3.3 infections/10,000 patient days in transfused patients (p = 0.002). The infection rate remained stable in nontransfused patients at 1.5 infections/10,000 patient days both pre‐ and postimplementation of universal leukoreduction. Quantitatively similar decreases (33–45%) were seen in transfused surgical, medical and pediatric patients.
CONCLUSIONs: A substantial and statistically significant decrease in line related infections occurred coincident with implementation of universal leukore‐duction. These improved outcomes were observed in transfused but not nontransfused patients, across all clinical services, suggesting a causal relationship with universal leukoreduction.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/j.1537-2995.2005.00565.x</identifier><identifier>PMID: 16181215</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Oxford, UK and Malden, USA: Blackwell Science Inc</publisher><subject>Adolescent ; Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Transfusion ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Cardiology. Vascular system ; Catheters, Indwelling - adverse effects ; Child ; Child, Preschool ; Cross Infection - epidemiology ; Cross Infection - etiology ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Emergency and intensive care: infection, septic shock ; Erythrocyte Transfusion ; Female ; Humans ; Incidence ; Infant ; Infant, Newborn ; Infant, Premature ; Intensive care medicine ; Length of Stay - statistics & numerical data ; Leukocyte Reduction Procedures ; Male ; Medical sciences ; Middle Aged ; New York - epidemiology ; Platelet Transfusion ; Retrospective Studies ; Sepsis - epidemiology ; Sepsis - etiology ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Transfusion (Philadelphia, Pa.), 2005-10, Vol.45 (10), p.1632-1639</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4365-74022751f89ff93ea3fda58be1be418578600c949988822b484d5c86c5072ed83</citedby><cites>FETCH-LOGICAL-c4365-74022751f89ff93ea3fda58be1be418578600c949988822b484d5c86c5072ed83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1537-2995.2005.00565.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1537-2995.2005.00565.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17179440$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16181215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blumberg, Neil</creatorcontrib><creatorcontrib>Fine, Lynn</creatorcontrib><creatorcontrib>Gettings, Kelly F.</creatorcontrib><creatorcontrib>Heal, Joanna M.</creatorcontrib><title>Decreased sepsis related to indwelling venous access devices coincident with implementation of universal leukoreduction of blood transfusions</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: Randomized trials and animal models demonstrate that leukoreduction of transfusions can reduce the risk of post‐operative infections. We performed a retrospective study of sepsis related to indwelling venous access devices (line related infections) before and after the July 2000 implementation of universal leukoreduction.
METHODS: Line related infection data were collected from hospital infection control records for an 18‐month period before and after July 2000. Transfusion histories were obtained from transfusion service records.
RESULTS: Line related infections decreased in number from 150 to 98 (−35%) in transfused patients after implementation of universal leukoreduction, whereas line related infections increased from 41 to 45 (+10%) in nontransfused patients (p = 0.04). This corresponded to a decrease from 5.3 to 3.3 infections/10,000 patient days in transfused patients (p = 0.002). The infection rate remained stable in nontransfused patients at 1.5 infections/10,000 patient days both pre‐ and postimplementation of universal leukoreduction. Quantitatively similar decreases (33–45%) were seen in transfused surgical, medical and pediatric patients.
CONCLUSIONs: A substantial and statistically significant decrease in line related infections occurred coincident with implementation of universal leukore‐duction. These improved outcomes were observed in transfused but not nontransfused patients, across all clinical services, suggesting a causal relationship with universal leukoreduction.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Transfusion</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Cardiology. Vascular system</subject><subject>Catheters, Indwelling - adverse effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - etiology</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Erythrocyte Transfusion</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Intensive care medicine</subject><subject>Length of Stay - statistics & numerical data</subject><subject>Leukocyte Reduction Procedures</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>New York - epidemiology</subject><subject>Platelet Transfusion</subject><subject>Retrospective Studies</subject><subject>Sepsis - epidemiology</subject><subject>Sepsis - etiology</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUU1v1DAQtRCILoW_gHyBW4LtxB-5INFCt0gFJLSoR8txJuBtNtl6kt3tj-A_19td2iuWRp7xvHnjeUMI5Szn6XxY5lwWOhNVJXPBmMyTKZnvnpHZY-I5mTFW8ozzQpyQV4hLxpioGH9JTrjihgsuZ-TvZ_ARHEJDEdYYkEbo3JjCcaChb7bQdaH_TTfQDxNS5z0g0gY2ITnUD6H3oYF-pNsw_qFhte5glUI3hqGnQ0unPmwgoutoB9PNEKGZ_L9c3Q1D6hNdj-2E6RFfkxet6xDeHO9T8uviy-L8Mrv6Mf96_ukq82WhZKZLJoSWvDVV21YFuKJtnDQ18BpKbqQ2ijFflVVljBGiLk3ZSG-Ul0wLaExxSt4feNdxuJ0AR7sK6NOoroc0plVGcc25SkBzAPo4IEZo7TqGlYt3ljO7X4Vd2r3idq-43a_CPqzC7lLp22OPqV5B81R41D4B3h0BDr3r2qSDD_iE01xXZckS7uMBtw0d3P33B-zi58WDmwiyA0HAEXaPBC7eWKULLe3197md62v17WxxZoviHtYxtxI</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Blumberg, Neil</creator><creator>Fine, Lynn</creator><creator>Gettings, Kelly F.</creator><creator>Heal, Joanna M.</creator><general>Blackwell Science Inc</general><general>Blackwell Publishing</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>Decreased sepsis related to indwelling venous access devices coincident with implementation of universal leukoreduction of blood transfusions</title><author>Blumberg, Neil ; Fine, Lynn ; Gettings, Kelly F. ; Heal, Joanna M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4365-74022751f89ff93ea3fda58be1be418578600c949988822b484d5c86c5072ed83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Transfusion</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Cardiology. Vascular system</topic><topic>Catheters, Indwelling - adverse effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross Infection - epidemiology</topic><topic>Cross Infection - etiology</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Emergency and intensive care: infection, septic shock</topic><topic>Erythrocyte Transfusion</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Intensive care medicine</topic><topic>Length of Stay - statistics & numerical data</topic><topic>Leukocyte Reduction Procedures</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>New York - epidemiology</topic><topic>Platelet Transfusion</topic><topic>Retrospective Studies</topic><topic>Sepsis - epidemiology</topic><topic>Sepsis - etiology</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blumberg, Neil</creatorcontrib><creatorcontrib>Fine, Lynn</creatorcontrib><creatorcontrib>Gettings, Kelly F.</creatorcontrib><creatorcontrib>Heal, Joanna M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blumberg, Neil</au><au>Fine, Lynn</au><au>Gettings, Kelly F.</au><au>Heal, Joanna M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased sepsis related to indwelling venous access devices coincident with implementation of universal leukoreduction of blood transfusions</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2005-10</date><risdate>2005</risdate><volume>45</volume><issue>10</issue><spage>1632</spage><epage>1639</epage><pages>1632-1639</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: Randomized trials and animal models demonstrate that leukoreduction of transfusions can reduce the risk of post‐operative infections. We performed a retrospective study of sepsis related to indwelling venous access devices (line related infections) before and after the July 2000 implementation of universal leukoreduction.
METHODS: Line related infection data were collected from hospital infection control records for an 18‐month period before and after July 2000. Transfusion histories were obtained from transfusion service records.
RESULTS: Line related infections decreased in number from 150 to 98 (−35%) in transfused patients after implementation of universal leukoreduction, whereas line related infections increased from 41 to 45 (+10%) in nontransfused patients (p = 0.04). This corresponded to a decrease from 5.3 to 3.3 infections/10,000 patient days in transfused patients (p = 0.002). The infection rate remained stable in nontransfused patients at 1.5 infections/10,000 patient days both pre‐ and postimplementation of universal leukoreduction. Quantitatively similar decreases (33–45%) were seen in transfused surgical, medical and pediatric patients.
CONCLUSIONs: A substantial and statistically significant decrease in line related infections occurred coincident with implementation of universal leukore‐duction. These improved outcomes were observed in transfused but not nontransfused patients, across all clinical services, suggesting a causal relationship with universal leukoreduction.</abstract><cop>Oxford, UK and Malden, USA</cop><pub>Blackwell Science Inc</pub><pmid>16181215</pmid><doi>10.1111/j.1537-2995.2005.00565.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Transfusion (Philadelphia, Pa.), 2005-10, Vol.45 (10), p.1632-1639 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood and lymphatic vessels Blood Transfusion Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Cardiology. Vascular system Catheters, Indwelling - adverse effects Child Child, Preschool Cross Infection - epidemiology Cross Infection - etiology Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Emergency and intensive care: infection, septic shock Erythrocyte Transfusion Female Humans Incidence Infant Infant, Newborn Infant, Premature Intensive care medicine Length of Stay - statistics & numerical data Leukocyte Reduction Procedures Male Medical sciences Middle Aged New York - epidemiology Platelet Transfusion Retrospective Studies Sepsis - epidemiology Sepsis - etiology Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Decreased sepsis related to indwelling venous access devices coincident with implementation of universal leukoreduction of blood transfusions |
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