Retinoid/arsenic combination therapy of promyelocytic leukemia : induction of telomerase-dependent cell death

Acute promyelocytic leukemia (APL) is efficiently treated with a cell differentiation inducer, all-trans retinoic acid (ATRA). However, a significant percentage of patients still develop resistance to this treatment. Recently, arsenic trioxide (As2O3), alone or in combination with ATRA, has been ide...

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Veröffentlicht in:	Leukemia 2005-10, Vol.19 (10), p.1806-1811
Hauptverfasser:	TARKANYI, I, DUDOGNON, C, HILLION, J, PENDINO, F, LANOTTE, M, ARADI, J, SEGAL-BENDIRDJIAN, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute promyeloid leukemia Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Apoptosis - drug effects Arsenic Arsenic trioxide Arsenicals - administration & dosage Biological and medical sciences Cell death Cell differentiation Combination therapy Combinatorial analysis Differentiation (biology) DNA-Binding Proteins - metabolism Drug Resistance, Neoplasm Hematologic and hematopoietic diseases Humans Leukemia Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - enzymology Leukemia, Promyelocytic, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Neoplasm Proteins - metabolism Oncogene Proteins, Fusion - metabolism Oxides - administration & dosage Patients Promyeloid leukemia Remission Induction Retinoic acid Side effects Synergism Synergistic effect Telomerase Telomerase - metabolism Telomere - metabolism Telomeres Therapy Tretinoin - administration & dosage Tumor Cells, Cultured
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