Recombinant adenovirus-p21 attenuates proliferative responses associated with excessive scarring

Excessive cutaneous scarring is an important clinical disorder resulting in adverse tissue growth and function as well as undesirable cosmetic appearance. p21WAF−1/Cip−1 is a cyclin‐dependent kinase inhibitor that blocks cell cycle progression and inhibits cell proliferation. We used a recombinant a...

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Veröffentlicht in:	Wound repair and regeneration 2005-09, Vol.13 (5), p.480-490
Hauptverfasser:	Gu, Danling, Atencio, Isabella, Kang, David W., Looper, L. David, Ahmed, C. M. I., Levy, Alina, Maneval, Dan, Zepeda, Monica L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adult Animals Cell Proliferation Cells, Cultured Cicatrix - genetics Cicatrix - therapy Cyclin-Dependent Kinase Inhibitor p21 - genetics Fibroblasts Gene Transfer Techniques Genetic Vectors Humans Models, Animal Procollagen - genetics Rats Skin - physiopathology Wound Healing - genetics
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