The Abnormal Spindle-like, Microcephaly-associated (ASPM) Gene Encodes a Centrosomal Protein
Homozygous mutations in the abnormal spindle-like, microcephaly-associated ASPM gene are the leading cause of autosomal recessive primary microcephaly. ASPM is the putative human ortholog of the Drosophila melanogaster abnormal spindles gene (asp), which is essential for mitotic spindle function. He...
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| Veröffentlicht in: | Cell cycle (Georgetown, Tex.) Tex.), 2005-09, Vol.4 (9), p.1227-1229 |
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| creator | Zhong, Xueyan Liu, Limin Zhao, Ailian Pfeifer, Gerd P Xu, Xingzhi |
| description | Homozygous mutations in the abnormal spindle-like, microcephaly-associated
ASPM gene are the leading cause of autosomal recessive primary microcephaly. ASPM is
the putative human ortholog of the Drosophila melanogaster abnormal spindles gene
(asp), which is essential for mitotic spindle function. Here, we report that
downregulation of endogenous ASPM by siRNA decreases protein levels of endogenous
BRCA1. ASPM localizes to the centrosome in interphase and to the spindle poles from
prophase through telophase. These findings indicate that ASPM may be involved in
mitotic spindle function, possibly, through regulation of BRCA1. |
| doi_str_mv | 10.4161/cc.4.9.2029 |
| format | Article |
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ASPM gene are the leading cause of autosomal recessive primary microcephaly. ASPM is
the putative human ortholog of the Drosophila melanogaster abnormal spindles gene
(asp), which is essential for mitotic spindle function. Here, we report that
downregulation of endogenous ASPM by siRNA decreases protein levels of endogenous
BRCA1. ASPM localizes to the centrosome in interphase and to the spindle poles from
prophase through telophase. These findings indicate that ASPM may be involved in
mitotic spindle function, possibly, through regulation of BRCA1.</description><identifier>ISSN: 1538-4101</identifier><identifier>EISSN: 1551-4005</identifier><identifier>DOI: 10.4161/cc.4.9.2029</identifier><identifier>PMID: 16123590</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Binding ; Biology ; Bioscience ; BRCA1 Protein - biosynthesis ; Calcium ; Cancer ; Cell ; Cell Line ; Cell Line, Tumor ; Centrosome - metabolism ; Centrosome - ultrastructure ; Cycle ; DNA - chemistry ; Drosophila melanogaster ; Fluorescent Antibody Technique, Indirect ; Humans ; Immunoblotting ; Landes ; Microscopy, Fluorescence ; Mutation ; Nerve Tissue Proteins - metabolism ; Nerve Tissue Proteins - physiology ; Organogenesis ; Prophase ; Proteins ; RNA, Small Interfering - metabolism ; Spindle Apparatus - metabolism ; Telophase ; Transfection</subject><ispartof>Cell cycle (Georgetown, Tex.), 2005-09, Vol.4 (9), p.1227-1229</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-d02b9a847e5bab31ee46b536997a775a025b0f59a9ac95148cdf721c1da4f9b43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16123590$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhong, Xueyan</creatorcontrib><creatorcontrib>Liu, Limin</creatorcontrib><creatorcontrib>Zhao, Ailian</creatorcontrib><creatorcontrib>Pfeifer, Gerd P</creatorcontrib><creatorcontrib>Xu, Xingzhi</creatorcontrib><title>The Abnormal Spindle-like, Microcephaly-associated (ASPM) Gene Encodes a Centrosomal Protein</title><title>Cell cycle (Georgetown, Tex.)</title><addtitle>Cell Cycle</addtitle><description>Homozygous mutations in the abnormal spindle-like, microcephaly-associated
ASPM gene are the leading cause of autosomal recessive primary microcephaly. ASPM is
the putative human ortholog of the Drosophila melanogaster abnormal spindles gene
(asp), which is essential for mitotic spindle function. Here, we report that
downregulation of endogenous ASPM by siRNA decreases protein levels of endogenous
BRCA1. ASPM localizes to the centrosome in interphase and to the spindle poles from
prophase through telophase. These findings indicate that ASPM may be involved in
mitotic spindle function, possibly, through regulation of BRCA1.</description><subject>Animals</subject><subject>Binding</subject><subject>Biology</subject><subject>Bioscience</subject><subject>BRCA1 Protein - biosynthesis</subject><subject>Calcium</subject><subject>Cancer</subject><subject>Cell</subject><subject>Cell Line</subject><subject>Cell Line, Tumor</subject><subject>Centrosome - metabolism</subject><subject>Centrosome - ultrastructure</subject><subject>Cycle</subject><subject>DNA - chemistry</subject><subject>Drosophila melanogaster</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Landes</subject><subject>Microscopy, Fluorescence</subject><subject>Mutation</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Organogenesis</subject><subject>Prophase</subject><subject>Proteins</subject><subject>RNA, Small Interfering - metabolism</subject><subject>Spindle Apparatus - metabolism</subject><subject>Telophase</subject><subject>Transfection</subject><issn>1538-4101</issn><issn>1551-4005</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFLwzAUgIMobk5P3qUnUbRd0iZtcxxjTmHDweZNCEn6yqJtU5PusH9vx4ae8g7f-x75ELolOKIkJWOtIxrxKMYxP0NDwhgJKcbs_DAneUgJJgN05f0XxnGecXKJBv1anDCOh-hzs4VgohrralkF69Y0RQVhZb7hOVga7ayGdiurfSi9t9rIDorgYbJeLR-DOTQQzBptC_CBDKbQdM56e_CsnO3ANNfoopSVh5vTO0IfL7PN9DVcvM_fppNFqGmCu7DAseIypxkwJVVCAGiqWJJynsksYxLHTOGSccml5ozQXBdlFhNNCklLrmgyQvdHb-vszw58J2rjNVSVbMDuvEjzlCRpznrw6Qj2H_PeQSlaZ2rp9oJgcYgptBZUcHGI2dN3J-1O1VD8s6d6PTA-Av2hPoIy1msDjYY_tNdJ1xldwVH5Cy6dgFI</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Zhong, Xueyan</creator><creator>Liu, Limin</creator><creator>Zhao, Ailian</creator><creator>Pfeifer, Gerd P</creator><creator>Xu, Xingzhi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>The Abnormal Spindle-like, Microcephaly-associated (ASPM) Gene Encodes a Centrosomal Protein</title><author>Zhong, Xueyan ; Liu, Limin ; Zhao, Ailian ; Pfeifer, Gerd P ; Xu, Xingzhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-d02b9a847e5bab31ee46b536997a775a025b0f59a9ac95148cdf721c1da4f9b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Binding</topic><topic>Biology</topic><topic>Bioscience</topic><topic>BRCA1 Protein - biosynthesis</topic><topic>Calcium</topic><topic>Cancer</topic><topic>Cell</topic><topic>Cell Line</topic><topic>Cell Line, Tumor</topic><topic>Centrosome - metabolism</topic><topic>Centrosome - ultrastructure</topic><topic>Cycle</topic><topic>DNA - chemistry</topic><topic>Drosophila melanogaster</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Landes</topic><topic>Microscopy, Fluorescence</topic><topic>Mutation</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>Organogenesis</topic><topic>Prophase</topic><topic>Proteins</topic><topic>RNA, Small Interfering - metabolism</topic><topic>Spindle Apparatus - metabolism</topic><topic>Telophase</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhong, Xueyan</creatorcontrib><creatorcontrib>Liu, Limin</creatorcontrib><creatorcontrib>Zhao, Ailian</creatorcontrib><creatorcontrib>Pfeifer, Gerd P</creatorcontrib><creatorcontrib>Xu, Xingzhi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell cycle (Georgetown, Tex.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhong, Xueyan</au><au>Liu, Limin</au><au>Zhao, Ailian</au><au>Pfeifer, Gerd P</au><au>Xu, Xingzhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Abnormal Spindle-like, Microcephaly-associated (ASPM) Gene Encodes a Centrosomal Protein</atitle><jtitle>Cell cycle (Georgetown, Tex.)</jtitle><addtitle>Cell Cycle</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>4</volume><issue>9</issue><spage>1227</spage><epage>1229</epage><pages>1227-1229</pages><issn>1538-4101</issn><eissn>1551-4005</eissn><abstract>Homozygous mutations in the abnormal spindle-like, microcephaly-associated
ASPM gene are the leading cause of autosomal recessive primary microcephaly. ASPM is
the putative human ortholog of the Drosophila melanogaster abnormal spindles gene
(asp), which is essential for mitotic spindle function. Here, we report that
downregulation of endogenous ASPM by siRNA decreases protein levels of endogenous
BRCA1. ASPM localizes to the centrosome in interphase and to the spindle poles from
prophase through telophase. These findings indicate that ASPM may be involved in
mitotic spindle function, possibly, through regulation of BRCA1.</abstract><cop>United States</cop><pmid>16123590</pmid><doi>10.4161/cc.4.9.2029</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Binding Biology Bioscience BRCA1 Protein - biosynthesis Calcium Cancer Cell Cell Line Cell Line, Tumor Centrosome - metabolism Centrosome - ultrastructure Cycle DNA - chemistry Drosophila melanogaster Fluorescent Antibody Technique, Indirect Humans Immunoblotting Landes Microscopy, Fluorescence Mutation Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - physiology Organogenesis Prophase Proteins RNA, Small Interfering - metabolism Spindle Apparatus - metabolism Telophase Transfection |
| title | The Abnormal Spindle-like, Microcephaly-associated (ASPM) Gene Encodes a Centrosomal Protein |
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