AAV delivery of mineralocorticoid receptor shRNA prevents progression of cold-induced hypertension and attenuates renal damage

The aim of this study was to determine the effect of RNA interference inhibition of mineralocorticoid receptor (MR) on cold-induced hypertension (CIH) and renal damage. Recombinant adeno-associated virus (AAV) carrying short hairpin small interference (si)RNA for MR (AAV.MR-shRNA) was constructed an...

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Veröffentlicht in:	Gene therapy 2006-07, Vol.13 (14), p.1097-1103
Hauptverfasser:	Wang, X, Skelley, L, Cade, R, Sun, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus Adenoviruses Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antihypertensives Aorta - chemistry Applied cell therapy and gene therapy Atrophy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Blood pressure Care and treatment Cell Biology Cell receptors Cell structures and functions Cold Temperature - adverse effects Creatinine Dependovirus - genetics Disease Progression Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genetic aspects Genetic Therapy - methods Health. Pharmaceutical industry Human Genetics Hypertension Hypertension - etiology Hypertension - pathology Hypertension - therapy Hypertrophy Immunohistochemistry - methods Industrial applications and implications. Economical aspects Inhibitor drugs Intravenous administration Kidney - chemistry Kidney - pathology Kidney diseases Kidney Diseases - pathology Kidney Diseases - therapy Kidneys Medical sciences Miscellaneous Molecular and cellular biology Myocardium - chemistry Nanotechnology original-article Proteinuria Rats Rats, Sprague-Dawley Receptors, Androgen - analysis Receptors, Glucocorticoid - analysis Receptors, Mineralocorticoid - analysis Receptors, Mineralocorticoid - genetics Receptors, Mineralocorticoid - metabolism Renal function Renal tubules Ribonucleic acid RNA RNA, Small Interfering - genetics RNA-mediated interference Rodents siRNA Transfusions. Complications. Transfusion reactions. Cell and gene therapy Viruses
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