A novel N‐terminal hydrophobic motif mediates constitutive degradation of serum‐ and glucocorticoid‐induced kinase‐1 by the ubiquitin–proteasome pathway

Serum‐ and glucocorticoid‐induced protein kinase‐1 (SGK‐1) plays a critical role in regulation of the epithelial sodium channel, ENaC. SGK‐1 also shares significant catalytic domain homology with protein kinase B (PKB/AKT‐1) and is a downstream effector of antiapoptotic phosphoinositide 3‐kinase sig...

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