Glycaemic control in relation to xanthine oxidase and antioxidant indices in Malaysian Type 2 diabetes patients
Aims Increased oxidative stress and oxidative damage are present in Type 2 diabetes mellitus (DM). The aim of this study was to assess the oxidative stress levels in the three major ethnic groups in Malaysia and to study the association between glycaemic control and oxidant–antioxidant levels in th...
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| Veröffentlicht in: | Diabetic medicine 2005-10, Vol.22 (10), p.1343-1346 |
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| creator | Kuppusamy, U. R. Indran, M. Rokiah, P. |
| description | Aims Increased oxidative stress and oxidative damage are present in Type 2 diabetes mellitus (DM). The aim of this study was to assess the oxidative stress levels in the three major ethnic groups in Malaysia and to study the association between glycaemic control and oxidant–antioxidant levels in these patients.
Methods Oxidative indices and glycaemic control were assessed in 650 Type 2 DM patients and 280 healthy age‐matched controls by known established methods.
Results Type 2 DM patients had significantly lower levels of antioxidant enzymes and non‐enzymatic antioxidant (FRAP) and increased levels of HbA1c, fasting blood glucose (FBG), malondialdehyde (MDA) and xanthine oxidase (XO) when compared with control subjects. Markers of oxidative stress were more apparent in Indian patients compared with Malay and Chinese patients. Correlation analysis of oxidant–antioxidant parameters as a function of HbA1c in each ethnic group revealed a strong association of HbA1c with oxidative indices.
Conclusions The present study provides evidence for the possible contribution of XO to oxidative stress and the pathophysiology of diabetes. HbA1c remains an important marker of glycaemic control for the management of Type 2 DM, but other confounding factors that predispose or lead to oxidative stress should also be taken into consideration. |
| doi_str_mv | 10.1111/j.1464-5491.2005.01630.x |
| format | Article |
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Methods Oxidative indices and glycaemic control were assessed in 650 Type 2 DM patients and 280 healthy age‐matched controls by known established methods.
Results Type 2 DM patients had significantly lower levels of antioxidant enzymes and non‐enzymatic antioxidant (FRAP) and increased levels of HbA1c, fasting blood glucose (FBG), malondialdehyde (MDA) and xanthine oxidase (XO) when compared with control subjects. Markers of oxidative stress were more apparent in Indian patients compared with Malay and Chinese patients. Correlation analysis of oxidant–antioxidant parameters as a function of HbA1c in each ethnic group revealed a strong association of HbA1c with oxidative indices.
Conclusions The present study provides evidence for the possible contribution of XO to oxidative stress and the pathophysiology of diabetes. HbA1c remains an important marker of glycaemic control for the management of Type 2 DM, but other confounding factors that predispose or lead to oxidative stress should also be taken into consideration.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/j.1464-5491.2005.01630.x</identifier><identifier>PMID: 16176194</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antioxidants - analysis ; Biological and medical sciences ; Biomarkers - blood ; Blood Glucose - analysis ; China - ethnology ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - ethnology ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; ethnicity ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; glycaemic control ; Glycated Hemoglobin A - analysis ; Humans ; India - ethnology ; Malaysia - epidemiology ; Male ; Medical sciences ; Middle Aged ; oxidant-antioxidant indices ; Oxidative Stress - physiology ; Xanthine Oxidase - blood</subject><ispartof>Diabetic medicine, 2005-10, Vol.22 (10), p.1343-1346</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5010-f36119f24d77d72c74c627435cafb6847a41156c3a3ea183e3897151606330b23</citedby><cites>FETCH-LOGICAL-c5010-f36119f24d77d72c74c627435cafb6847a41156c3a3ea183e3897151606330b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-5491.2005.01630.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-5491.2005.01630.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17097615$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16176194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuppusamy, U. R.</creatorcontrib><creatorcontrib>Indran, M.</creatorcontrib><creatorcontrib>Rokiah, P.</creatorcontrib><title>Glycaemic control in relation to xanthine oxidase and antioxidant indices in Malaysian Type 2 diabetes patients</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Aims Increased oxidative stress and oxidative damage are present in Type 2 diabetes mellitus (DM). The aim of this study was to assess the oxidative stress levels in the three major ethnic groups in Malaysia and to study the association between glycaemic control and oxidant–antioxidant levels in these patients.
Methods Oxidative indices and glycaemic control were assessed in 650 Type 2 DM patients and 280 healthy age‐matched controls by known established methods.
Results Type 2 DM patients had significantly lower levels of antioxidant enzymes and non‐enzymatic antioxidant (FRAP) and increased levels of HbA1c, fasting blood glucose (FBG), malondialdehyde (MDA) and xanthine oxidase (XO) when compared with control subjects. Markers of oxidative stress were more apparent in Indian patients compared with Malay and Chinese patients. Correlation analysis of oxidant–antioxidant parameters as a function of HbA1c in each ethnic group revealed a strong association of HbA1c with oxidative indices.
Conclusions The present study provides evidence for the possible contribution of XO to oxidative stress and the pathophysiology of diabetes. HbA1c remains an important marker of glycaemic control for the management of Type 2 DM, but other confounding factors that predispose or lead to oxidative stress should also be taken into consideration.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antioxidants - analysis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - analysis</subject><subject>China - ethnology</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - ethnology</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>ethnicity</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>glycaemic control</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>India - ethnology</subject><subject>Malaysia - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>oxidant-antioxidant indices</subject><subject>Oxidative Stress - physiology</subject><subject>Xanthine Oxidase - blood</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMGO0zAQhi0EYrsLr4B8gVuCJ3bs5MABlSWL1IU9FHG0po4jXFynxKlI3h6HVrtXLI1sa75vbP2EUGA5pPV-n4OQIitFDXnBWJkzkJzl0zOyemw8JyumRJFxpuCKXMe4ZwyKmtcvyRVIUBJqsSJ942eD9uAMNX0Yh95TF-hgPY6uD3Ts6YRh_OmCpf3kWoyWYmhTpfZyD2PiW2dsXLx79DhHh4Fu56OlBW0d7uyYmsc0z4YxviIvOvTRvr7sN-T759vt-i7bfGu-rD9uMlMyYFnHJUDdFaJVqlWFUcLIQgleGux2shIKBUApDUduESpueVUrKEEyyTnbFfyGvDvPPQ7975ONoz64aKz3GGx_ilpWklWpElidQTP0MQ6208fBHXCYNTC9hK33eslUL5nqJWz9L2w9JfXN5Y3T7mDbJ_GSbgLeXgCMBn03YDAuPnGK1QksE_fhzP1x3s7__QH96f52OSU_O_sujnZ69HH4paXiqtQ_vjZ6_QDbh03T6JL_Bfj9qTY</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Kuppusamy, U. R.</creator><creator>Indran, M.</creator><creator>Rokiah, P.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>Glycaemic control in relation to xanthine oxidase and antioxidant indices in Malaysian Type 2 diabetes patients</title><author>Kuppusamy, U. R. ; Indran, M. ; Rokiah, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5010-f36119f24d77d72c74c627435cafb6847a41156c3a3ea183e3897151606330b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antioxidants - analysis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - analysis</topic><topic>China - ethnology</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - ethnology</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>ethnicity</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>glycaemic control</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>India - ethnology</topic><topic>Malaysia - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>oxidant-antioxidant indices</topic><topic>Oxidative Stress - physiology</topic><topic>Xanthine Oxidase - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuppusamy, U. R.</creatorcontrib><creatorcontrib>Indran, M.</creatorcontrib><creatorcontrib>Rokiah, P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuppusamy, U. R.</au><au>Indran, M.</au><au>Rokiah, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycaemic control in relation to xanthine oxidase and antioxidant indices in Malaysian Type 2 diabetes patients</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2005-10</date><risdate>2005</risdate><volume>22</volume><issue>10</issue><spage>1343</spage><epage>1346</epage><pages>1343-1346</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aims Increased oxidative stress and oxidative damage are present in Type 2 diabetes mellitus (DM). The aim of this study was to assess the oxidative stress levels in the three major ethnic groups in Malaysia and to study the association between glycaemic control and oxidant–antioxidant levels in these patients.
Methods Oxidative indices and glycaemic control were assessed in 650 Type 2 DM patients and 280 healthy age‐matched controls by known established methods.
Results Type 2 DM patients had significantly lower levels of antioxidant enzymes and non‐enzymatic antioxidant (FRAP) and increased levels of HbA1c, fasting blood glucose (FBG), malondialdehyde (MDA) and xanthine oxidase (XO) when compared with control subjects. Markers of oxidative stress were more apparent in Indian patients compared with Malay and Chinese patients. Correlation analysis of oxidant–antioxidant parameters as a function of HbA1c in each ethnic group revealed a strong association of HbA1c with oxidative indices.
Conclusions The present study provides evidence for the possible contribution of XO to oxidative stress and the pathophysiology of diabetes. HbA1c remains an important marker of glycaemic control for the management of Type 2 DM, but other confounding factors that predispose or lead to oxidative stress should also be taken into consideration.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16176194</pmid><doi>10.1111/j.1464-5491.2005.01630.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antioxidants - analysis Biological and medical sciences Biomarkers - blood Blood Glucose - analysis China - ethnology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies ethnicity Etiopathogenesis. Screening. Investigations. Target tissue resistance Female glycaemic control Glycated Hemoglobin A - analysis Humans India - ethnology Malaysia - epidemiology Male Medical sciences Middle Aged oxidant-antioxidant indices Oxidative Stress - physiology Xanthine Oxidase - blood |
| title | Glycaemic control in relation to xanthine oxidase and antioxidant indices in Malaysian Type 2 diabetes patients |
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