Iron Binding Dendrimers: A Novel Approach for the Treatment of Haemochromatosis

A range of iron binding dendrimers terminated with hexadentate ligands formed from hydroxypyridinone, hydroxypyranone, and catechol moieties have been synthesized in order to investigate their potential as clinically useful iron(III)-selective chelators capable of removing dietary iron from the gast...

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Veröffentlicht in:	Journal of medicinal chemistry 2006-07, Vol.49 (14), p.4171-4182
Hauptverfasser:	Zhou, Tao, Neubert, Hendrik, Liu, Ding Yong, Liu, Zu Dong, Ma, Yong Min, Kong, Xiao Le, Luo, Wei, Mark, Sykes, Hider, Robert C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dendrimers - chemical synthesis Dendrimers - chemistry Dendrimers - pharmacology General and cellular metabolism. Vitamins Hemochromatosis - drug therapy In Vitro Techniques Intestinal Absorption - drug effects Iron - metabolism Iron Chelating Agents - chemical synthesis Iron Chelating Agents - chemistry Iron Chelating Agents - pharmacology Male Medical sciences Pharmacology. Drug treatments Pyridones - chemical synthesis Pyridones - chemistry Pyridones - pharmacology Rats Rats, Wistar Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectrophotometry, Ultraviolet Structure-Activity Relationship
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