Expression of MAGE-A Cancer/Testis Antigens in Esophageal Squamous Cell Carcinomas
Background: Although the diagnosis and therapy of esophageal cancer have improved over the past decade, the prognosis remains dismal. Since MAGE-A cancer/testis antigens (CTA) are potential targets for immunotherapy, this study was aimed at evaluating their expression in these patients and its progn...
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| Veröffentlicht in: | Anticancer research 2006-05, Vol.26 (3B), p.2281-2287 |
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| creator | HAIER, J OWZCARECK, M GULLER, U SPAGNOLI, G. C BÜRGER, H SENNINGER, N KOCHER, Th |
| description | Background: Although the diagnosis and therapy of esophageal cancer have improved over the past decade, the prognosis remains
dismal. Since MAGE-A cancer/testis antigens (CTA) are potential targets for immunotherapy, this study was aimed at evaluating
their expression in these patients and its prognostic value. Materials and Methods: Using 57B monoclonal antibody, MAGE-A
CTA expression was analyzed in paraffin-embedded tumor specimens of 98 patients with esophageal squamous cell carcinoma or
adenocarcinomas who had undergone surgical resection. For all patients, a postoperative follow-up of at least 4 years was
available. The expression was quantified using a scoring system considering intensity and homogeneity of the immunostaining.
The prognostic relevance of MAGE-A expression was analyzed in univariate analyses as well as Cox proportional hazard regression
analysis. Results: 57B positivity could be detected in 38 tumors (38.8%). Positive staining was observed in five out of 32
adenocarcinomas (15.2%) and in 33 out of 66 (50%) squamous cell carcinomas. MAGE-A expression did not correlate with the TNM
classification, grading or age of the patients. Both univariate (p=0.88) and multivariate analyses (p=0.82) revealed that
MAGE-A expression lacked prognostic significance in esophageal carcinomas. Conclusion: MAGE-A was expressed in half of the
squamous cell carcinomas of the esophagus, but rarely in adenocarcinomas. Although its immunodetection was insufficient for
prognostic evaluation, the high expression rate suggests MAGE-A as a potential target for immunotherapy in the first group
with the ability for pretherapeutic testing. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68608216</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68608216</sourcerecordid><originalsourceid>FETCH-LOGICAL-h301t-da1dde1210f6ad4c24ea29e059eccc79110e8d85dfa013222ee36d44b1a2cfe73</originalsourceid><addsrcrecordid>eNqFkE1Pg0AQhonR2Fr9C4aL3oizu7DAEQlWkxoTrWcyXYayhi93S9R_7xpr9OZpLs-8XwfenMUpC-JIwKE3Bx5BEANEM-_E2hcAKdNEHHszJhPOJIi591i8j4as1UPvD7V_ny2LIPNz7BWZqzXZnbZ-1u_0lnrr694v7DA2uCVs_afXCbthsn5ObetejNL90KE99Y5qbC2d7e_Ce74p1vltsHpY3uXZKmgEsF1QIasqYpxBLbEKFQ8JeUoQpaSUci0YUFIlUVUjMME5JxKyCsMNQ65qisXCu_zWHc3wOrmoZaetclmwJxerlImEr5r_gizmITCZOvB8D06bjqpyNLpD81H-zOWAiz2AVmFbG7eTtr9cnAKEyR_HRm-bN22otB22rZMVJRouS3Fdcp4w8QleQoCO</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17240169</pqid></control><display><type>article</type><title>Expression of MAGE-A Cancer/Testis Antigens in Esophageal Squamous Cell Carcinomas</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>HAIER, J ; OWZCARECK, M ; GULLER, U ; SPAGNOLI, G. C ; BÜRGER, H ; SENNINGER, N ; KOCHER, Th</creator><creatorcontrib>HAIER, J ; OWZCARECK, M ; GULLER, U ; SPAGNOLI, G. C ; BÜRGER, H ; SENNINGER, N ; KOCHER, Th</creatorcontrib><description>Background: Although the diagnosis and therapy of esophageal cancer have improved over the past decade, the prognosis remains
dismal. Since MAGE-A cancer/testis antigens (CTA) are potential targets for immunotherapy, this study was aimed at evaluating
their expression in these patients and its prognostic value. Materials and Methods: Using 57B monoclonal antibody, MAGE-A
CTA expression was analyzed in paraffin-embedded tumor specimens of 98 patients with esophageal squamous cell carcinoma or
adenocarcinomas who had undergone surgical resection. For all patients, a postoperative follow-up of at least 4 years was
available. The expression was quantified using a scoring system considering intensity and homogeneity of the immunostaining.
The prognostic relevance of MAGE-A expression was analyzed in univariate analyses as well as Cox proportional hazard regression
analysis. Results: 57B positivity could be detected in 38 tumors (38.8%). Positive staining was observed in five out of 32
adenocarcinomas (15.2%) and in 33 out of 66 (50%) squamous cell carcinomas. MAGE-A expression did not correlate with the TNM
classification, grading or age of the patients. Both univariate (p=0.88) and multivariate analyses (p=0.82) revealed that
MAGE-A expression lacked prognostic significance in esophageal carcinomas. Conclusion: MAGE-A was expressed in half of the
squamous cell carcinomas of the esophagus, but rarely in adenocarcinomas. Although its immunodetection was insufficient for
prognostic evaluation, the high expression rate suggests MAGE-A as a potential target for immunotherapy in the first group
with the ability for pretherapeutic testing.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 16821603</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Adult ; Aged ; Antigens, Neoplasm - biosynthesis ; Biological and medical sciences ; Esophageal Neoplasms - immunology ; Esophageal Neoplasms - pathology ; Esophagus ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Melanoma-Specific Antigens ; Membrane Proteins - biosynthesis ; Middle Aged ; Neoplasm Proteins - biosynthesis ; Neoplasm Staging ; Neoplasms, Squamous Cell - immunology ; Neoplasms, Squamous Cell - pathology ; Proportional Hazards Models ; Tumors</subject><ispartof>Anticancer research, 2006-05, Vol.26 (3B), p.2281-2287</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17900486$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16821603$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HAIER, J</creatorcontrib><creatorcontrib>OWZCARECK, M</creatorcontrib><creatorcontrib>GULLER, U</creatorcontrib><creatorcontrib>SPAGNOLI, G. C</creatorcontrib><creatorcontrib>BÜRGER, H</creatorcontrib><creatorcontrib>SENNINGER, N</creatorcontrib><creatorcontrib>KOCHER, Th</creatorcontrib><title>Expression of MAGE-A Cancer/Testis Antigens in Esophageal Squamous Cell Carcinomas</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: Although the diagnosis and therapy of esophageal cancer have improved over the past decade, the prognosis remains
dismal. Since MAGE-A cancer/testis antigens (CTA) are potential targets for immunotherapy, this study was aimed at evaluating
their expression in these patients and its prognostic value. Materials and Methods: Using 57B monoclonal antibody, MAGE-A
CTA expression was analyzed in paraffin-embedded tumor specimens of 98 patients with esophageal squamous cell carcinoma or
adenocarcinomas who had undergone surgical resection. For all patients, a postoperative follow-up of at least 4 years was
available. The expression was quantified using a scoring system considering intensity and homogeneity of the immunostaining.
The prognostic relevance of MAGE-A expression was analyzed in univariate analyses as well as Cox proportional hazard regression
analysis. Results: 57B positivity could be detected in 38 tumors (38.8%). Positive staining was observed in five out of 32
adenocarcinomas (15.2%) and in 33 out of 66 (50%) squamous cell carcinomas. MAGE-A expression did not correlate with the TNM
classification, grading or age of the patients. Both univariate (p=0.88) and multivariate analyses (p=0.82) revealed that
MAGE-A expression lacked prognostic significance in esophageal carcinomas. Conclusion: MAGE-A was expressed in half of the
squamous cell carcinomas of the esophagus, but rarely in adenocarcinomas. Although its immunodetection was insufficient for
prognostic evaluation, the high expression rate suggests MAGE-A as a potential target for immunotherapy in the first group
with the ability for pretherapeutic testing.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens, Neoplasm - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Esophageal Neoplasms - immunology</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma-Specific Antigens</subject><subject>Membrane Proteins - biosynthesis</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Squamous Cell - immunology</subject><subject>Neoplasms, Squamous Cell - pathology</subject><subject>Proportional Hazards Models</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Pg0AQhonR2Fr9C4aL3oizu7DAEQlWkxoTrWcyXYayhi93S9R_7xpr9OZpLs-8XwfenMUpC-JIwKE3Bx5BEANEM-_E2hcAKdNEHHszJhPOJIi591i8j4as1UPvD7V_ny2LIPNz7BWZqzXZnbZ-1u_0lnrr694v7DA2uCVs_afXCbthsn5ObetejNL90KE99Y5qbC2d7e_Ce74p1vltsHpY3uXZKmgEsF1QIasqYpxBLbEKFQ8JeUoQpaSUci0YUFIlUVUjMME5JxKyCsMNQ65qisXCu_zWHc3wOrmoZaetclmwJxerlImEr5r_gizmITCZOvB8D06bjqpyNLpD81H-zOWAiz2AVmFbG7eTtr9cnAKEyR_HRm-bN22otB22rZMVJRouS3Fdcp4w8QleQoCO</recordid><startdate>20060501</startdate><enddate>20060501</enddate><creator>HAIER, J</creator><creator>OWZCARECK, M</creator><creator>GULLER, U</creator><creator>SPAGNOLI, G. C</creator><creator>BÜRGER, H</creator><creator>SENNINGER, N</creator><creator>KOCHER, Th</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20060501</creationdate><title>Expression of MAGE-A Cancer/Testis Antigens in Esophageal Squamous Cell Carcinomas</title><author>HAIER, J ; OWZCARECK, M ; GULLER, U ; SPAGNOLI, G. C ; BÜRGER, H ; SENNINGER, N ; KOCHER, Th</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h301t-da1dde1210f6ad4c24ea29e059eccc79110e8d85dfa013222ee36d44b1a2cfe73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens, Neoplasm - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>Esophageal Neoplasms - immunology</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma-Specific Antigens</topic><topic>Membrane Proteins - biosynthesis</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Squamous Cell - immunology</topic><topic>Neoplasms, Squamous Cell - pathology</topic><topic>Proportional Hazards Models</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HAIER, J</creatorcontrib><creatorcontrib>OWZCARECK, M</creatorcontrib><creatorcontrib>GULLER, U</creatorcontrib><creatorcontrib>SPAGNOLI, G. C</creatorcontrib><creatorcontrib>BÜRGER, H</creatorcontrib><creatorcontrib>SENNINGER, N</creatorcontrib><creatorcontrib>KOCHER, Th</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HAIER, J</au><au>OWZCARECK, M</au><au>GULLER, U</au><au>SPAGNOLI, G. C</au><au>BÜRGER, H</au><au>SENNINGER, N</au><au>KOCHER, Th</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of MAGE-A Cancer/Testis Antigens in Esophageal Squamous Cell Carcinomas</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2006-05-01</date><risdate>2006</risdate><volume>26</volume><issue>3B</issue><spage>2281</spage><epage>2287</epage><pages>2281-2287</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Although the diagnosis and therapy of esophageal cancer have improved over the past decade, the prognosis remains
dismal. Since MAGE-A cancer/testis antigens (CTA) are potential targets for immunotherapy, this study was aimed at evaluating
their expression in these patients and its prognostic value. Materials and Methods: Using 57B monoclonal antibody, MAGE-A
CTA expression was analyzed in paraffin-embedded tumor specimens of 98 patients with esophageal squamous cell carcinoma or
adenocarcinomas who had undergone surgical resection. For all patients, a postoperative follow-up of at least 4 years was
available. The expression was quantified using a scoring system considering intensity and homogeneity of the immunostaining.
The prognostic relevance of MAGE-A expression was analyzed in univariate analyses as well as Cox proportional hazard regression
analysis. Results: 57B positivity could be detected in 38 tumors (38.8%). Positive staining was observed in five out of 32
adenocarcinomas (15.2%) and in 33 out of 66 (50%) squamous cell carcinomas. MAGE-A expression did not correlate with the TNM
classification, grading or age of the patients. Both univariate (p=0.88) and multivariate analyses (p=0.82) revealed that
MAGE-A expression lacked prognostic significance in esophageal carcinomas. Conclusion: MAGE-A was expressed in half of the
squamous cell carcinomas of the esophagus, but rarely in adenocarcinomas. Although its immunodetection was insufficient for
prognostic evaluation, the high expression rate suggests MAGE-A as a potential target for immunotherapy in the first group
with the ability for pretherapeutic testing.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>16821603</pmid><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Antigens, Neoplasm - biosynthesis Biological and medical sciences Esophageal Neoplasms - immunology Esophageal Neoplasms - pathology Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Melanoma-Specific Antigens Membrane Proteins - biosynthesis Middle Aged Neoplasm Proteins - biosynthesis Neoplasm Staging Neoplasms, Squamous Cell - immunology Neoplasms, Squamous Cell - pathology Proportional Hazards Models Tumors |
| title | Expression of MAGE-A Cancer/Testis Antigens in Esophageal Squamous Cell Carcinomas |
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