Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma

Promoter hypermethylation and histone deacetylation are common epigenetic mechanisms implicated in the transcriptional silencing of tumor suppressor genes in human cancer. We treated two immortalized glioma cell lines, T98 and U87, and 10 patient-derived primary glioma cell lines with trichostatin A...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-07, Vol.66 (13), p.6665-6674
Hauptverfasser:	Foltz, Greg, Ryu, Gi-Yung, Yoon, Jae-Geun, Nelson, Timothy, Fahey, Jessica, Frakes, Amanda, Lee, Hwahyung, Field, Lorie, Zander, Kaitlin, Sibenaller, Zita, Ryken, Timothy C, Vibhakar, Rajeev, Hood, Leroy, Madan, Anup
Format:	Artikel
Sprache:	eng
Schlagworte:	Azacitidine - analogs & derivatives Azacitidine - pharmacology Brain Neoplasms - genetics Brain Neoplasms - pathology DNA Methylation Gene Expression - drug effects Gene Expression Profiling Gene Silencing Genes, Tumor Suppressor Genome, Human Glioma - genetics Glioma - pathology Histones - genetics Histones - metabolism Humans Hydroxamic Acids - pharmacology Nerve Tissue Proteins - genetics Promoter Regions, Genetic
Online-Zugang:	Volltext
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