Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo

Toll-like receptors (TLRs) are able to interact with pathogen-derived products and their signals induce the coordinated activation of innate and adaptive immune mechanisms. Dendritic cells (DCs) play a central role in these events. As the different TLRs are able to trigger MyD88/TRIF-dependent and -...

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Veröffentlicht in:	Blood 2006-07, Vol.108 (2), p.544-550
Hauptverfasser:	Warger, Tobias, Osterloh, Philipp, Rechtsteiner, Gerd, Fassbender, Melanie, Heib, Valeska, Schmid, Beate, Schmitt, Edgar, Schild, Hansjörg, Radsak, Markus P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Biological and medical sciences Bone Marrow Cells Dendritic Cells - immunology Dendritic Cells - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Immunity Immunobiology Ligands Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Modulation of the immune response (stimulation, suppression) Myeloid Differentiation Factor 88 Signal Transduction T-Lymphocytes T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Regulatory Toll-Like Receptor 3 - immunology Toll-Like Receptor 3 - metabolism Toll-Like Receptor 7 - immunology Toll-Like Receptor 7 - metabolism Toll-Like Receptors - immunology Toll-Like Receptors - metabolism
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