Discovery of Potent and Orally Available Malonyl-CoA Decarboxylase Inhibitors as Cardioprotective Agents

Discovery of 5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamides as a new class of malonyl-coenzyme A decarboxylase (MCD) inhibitors is described. tert-Butyl 3-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-4,5-dihydroisoxazole-3-carboxamido)butanoate (5, CBM-301940...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2006-07, Vol.49 (14), p.4055-4058
Hauptverfasser:	Cheng, Jie-Fei, Huang, Yujin, Penuliar, Richard, Nishimoto, Masahiro, Liu, Larry, Arrhenius, Thomas, Yang, Guang, O'Leary, Eoin, Barbosa, Miguel, Barr, Rick, Dyck, Jason R. B, Lopaschuk, Gary D, Nadzan, Alex M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Biological Availability Carboxy-Lyases - antagonists & inhibitors Cardiotonic Agents - chemical synthesis Cardiotonic Agents - pharmacokinetics Cardiotonic Agents - pharmacology Cardiovascular system Crystallography, X-Ray Isoxazoles - chemical synthesis Isoxazoles - pharmacokinetics Isoxazoles - pharmacology Medical sciences Miscellaneous Molecular Conformation Myocardial Ischemia - drug therapy Myocardial Ischemia - physiopathology Myocardial Reperfusion Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Stereoisomerism Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!