Invasive group A streptococcal infection with pancarditis caused by a new emm-type 12 allele of Streptococcus pyogenes

Throughout the 1980s, a progressive increase in the incidence of Streptococcus pyogenes-related invasive infections has occurred. It has been suggested that a host-related immunogenetic background, as well as bacterial virulence factors may play an important role in the outcome of streptococcal infe...

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Veröffentlicht in:The Journal of infection 2006-07, Vol.53 (1), p.e1-e4
Hauptverfasser: Özkaya, Gülşen, Shorbagi, Ali, Ülger, Zekeriya, Saglam, Arzu, Aybar, Melda, Şardan, Yeşim Çetinkaya, Uzun, Ömrüm
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container_issue 1
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container_title The Journal of infection
container_volume 53
creator Özkaya, Gülşen
Shorbagi, Ali
Ülger, Zekeriya
Saglam, Arzu
Aybar, Melda
Şardan, Yeşim Çetinkaya
Uzun, Ömrüm
description Throughout the 1980s, a progressive increase in the incidence of Streptococcus pyogenes-related invasive infections has occurred. It has been suggested that a host-related immunogenetic background, as well as bacterial virulence factors may play an important role in the outcome of streptococcal infections. Here, we present the first case of pancarditis in the literature caused by direct bacterial invasion due to a new emm-type 12 allele of S. pyogenes in an immunocompetent patient. The pathogenesis of this invasive infection, as well as predictors of poor prognosis are discussed.
doi_str_mv 10.1016/j.jinf.2005.10.006
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subjects Adult
Alleles
Antigens, Bacterial - genetics
Bacterial Outer Membrane Proteins - genetics
Carrier Proteins - genetics
emm-Type 12 allele
Fatal Outcome
Female
Humans
Invasive infection
Myocarditis - microbiology
Pancarditis
Sepsis - microbiology
Streptococcal Infections - microbiology
Streptococcus pyogenes
Streptococcus pyogenes - classification
Streptococcus pyogenes - genetics
Streptococcus pyogenes - isolation & purification
title Invasive group A streptococcal infection with pancarditis caused by a new emm-type 12 allele of Streptococcus pyogenes
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