MGMT Promoter Methylation and Field Defect in Sporadic Colorectal Cancer

Background: Sporadic colorectal cancers often arise from a region of cells characterized by a “field defect” that has not been well defined molecularly. DNA methylation has been proposed as a candidate mediator of this field defect. The DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) i...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2005-09, Vol.97 (18), p.1330-1338
Hauptverfasser:	Shen, Lanlan, Kondo, Yutaka, Rosner, Gary L., Xiao, Lianchun, Hernandez, Natalie Supunpong, Vilaythong, Jill, Houlihan, P. Scott, Krouse, Robert S., Prasad, Anil R., Einspahr, Janine G., Buckmeier, Julie, Alberts, David S., Hamilton, Stanley R., Issa, Jean-Pierre J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - genetics Cell Line, Tumor Clinical trials Colorectal cancer Colorectal Neoplasms - enzymology Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Deoxyribonucleic acid DNA DNA Methylation Epigenesis, Genetic Gastroenterology. Liver. Pancreas. Abdomen Gene Silencing Humans Intestinal Mucosa - enzymology Intestinal Mucosa - pathology Medical sciences Mutation O-Methylguanine-DNA Methyltransferase - genetics Polymerase Chain Reaction - methods Promoter Regions, Genetic Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins Risk Factors Sensitivity and Specificity Sequence Analysis, DNA Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Sulfites Tumor Suppressor Protein p53 - genetics Tumors
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