Inhibition of Luteinizing Hormone Secretion by Localized Administration of Estrogen, but not Dihydrotestosterone, Is Enhanced in the Ventromedial Hypothalamus During Feed Restriction in the Young Wether
The ability of steroids to inhibit LH secretion is enhanced during undernutrition. To identify potential hypothalamic sites at which this enhancement may occur, we examined LH secretion in feed-restricted or fed young wethers treated with locally administered metabolites of testosterone. In experime...
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| Veröffentlicht in: | Biology of reproduction 2005-10, Vol.73 (4), p.781-789 |
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| creator | MCMANUS, Christina J GOODMAN, Robert L LLANZA, Nancy V VALENT, Miroslav DOBBINS, Adam B CONNORS, John M HILEMAN, Stanley M |
| description | The ability of steroids to inhibit LH secretion is enhanced during undernutrition. To identify potential hypothalamic sites
at which this enhancement may occur, we examined LH secretion in feed-restricted or fed young wethers treated with locally
administered metabolites of testosterone. In experiment 1, microimplants containing crystalline estradiol-17β (E) or cholesterol
were administered via chronic guide tubes directed to the preoptic area (POA) or ventromedial hypothalamus (VMH) in fed or
feed-restricted wethers. E treatment in the VMH decreased LH pulse frequency, pulse amplitude, and mean LH concentration in
feed-restricted, but not fed, wethers. E may act in the POA to suppress LH under feed restriction, but definite conclusions
cannot be drawn because of steroid-independent effects of feed restriction on LH pulse frequency. In experiment 2, the effect
of dihydrotestosterone (DHT) in the VMH was determined. DHT administration to the VMH did not alter LH secretion in either
feed-restricted or fed wethers. Thus the VMH is one site wherein E negative feedback is enhanced during feed restriction in
the wether. In contrast, we found no evidence for enhanced responsiveness to androgen negative feedback within the VMH of
feed-restricted wethers. We suggest that increased sensitivity within the VMH to E, but not to DHT, is important for suppressing
LH secretion in undernourished male sheep.
Abstract
Increased sensitivity within the ventrolmedial hypothalamus to E, but not to DHT, is important for suppressing LH secretion
in undernourished male sheep |
| doi_str_mv | 10.1095/biolreprod.105.042275 |
| format | Article |
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at which this enhancement may occur, we examined LH secretion in feed-restricted or fed young wethers treated with locally
administered metabolites of testosterone. In experiment 1, microimplants containing crystalline estradiol-17β (E) or cholesterol
were administered via chronic guide tubes directed to the preoptic area (POA) or ventromedial hypothalamus (VMH) in fed or
feed-restricted wethers. E treatment in the VMH decreased LH pulse frequency, pulse amplitude, and mean LH concentration in
feed-restricted, but not fed, wethers. E may act in the POA to suppress LH under feed restriction, but definite conclusions
cannot be drawn because of steroid-independent effects of feed restriction on LH pulse frequency. In experiment 2, the effect
of dihydrotestosterone (DHT) in the VMH was determined. DHT administration to the VMH did not alter LH secretion in either
feed-restricted or fed wethers. Thus the VMH is one site wherein E negative feedback is enhanced during feed restriction in
the wether. In contrast, we found no evidence for enhanced responsiveness to androgen negative feedback within the VMH of
feed-restricted wethers. We suggest that increased sensitivity within the VMH to E, but not to DHT, is important for suppressing
LH secretion in undernourished male sheep.
Abstract
Increased sensitivity within the ventrolmedial hypothalamus to E, but not to DHT, is important for suppressing LH secretion
in undernourished male sheep</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod.105.042275</identifier><identifier>PMID: 15972883</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Animals ; Biological and medical sciences ; Diet ; Dihydrotestosterone - administration & dosage ; Dihydrotestosterone - pharmacology ; Dopamine Antagonists - pharmacology ; Drug Implants ; Estradiol - administration & dosage ; Estradiol - pharmacology ; Fundamental and applied biological sciences. Psychology ; Hormone metabolism and regulation ; Luteinizing Hormone - drug effects ; Luteinizing Hormone - secretion ; Male ; Mammalian female genital system ; Orchiectomy ; Preoptic Area - drug effects ; Preoptic Area - metabolism ; Sheep ; Sulpiride - pharmacology ; Ventromedial Hypothalamic Nucleus - drug effects ; Ventromedial Hypothalamic Nucleus - metabolism ; Vertebrates: reproduction</subject><ispartof>Biology of reproduction, 2005-10, Vol.73 (4), p.781-789</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17126851$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15972883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MCMANUS, Christina J</creatorcontrib><creatorcontrib>GOODMAN, Robert L</creatorcontrib><creatorcontrib>LLANZA, Nancy V</creatorcontrib><creatorcontrib>VALENT, Miroslav</creatorcontrib><creatorcontrib>DOBBINS, Adam B</creatorcontrib><creatorcontrib>CONNORS, John M</creatorcontrib><creatorcontrib>HILEMAN, Stanley M</creatorcontrib><title>Inhibition of Luteinizing Hormone Secretion by Localized Administration of Estrogen, but not Dihydrotestosterone, Is Enhanced in the Ventromedial Hypothalamus During Feed Restriction in the Young Wether</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>The ability of steroids to inhibit LH secretion is enhanced during undernutrition. To identify potential hypothalamic sites
at which this enhancement may occur, we examined LH secretion in feed-restricted or fed young wethers treated with locally
administered metabolites of testosterone. In experiment 1, microimplants containing crystalline estradiol-17β (E) or cholesterol
were administered via chronic guide tubes directed to the preoptic area (POA) or ventromedial hypothalamus (VMH) in fed or
feed-restricted wethers. E treatment in the VMH decreased LH pulse frequency, pulse amplitude, and mean LH concentration in
feed-restricted, but not fed, wethers. E may act in the POA to suppress LH under feed restriction, but definite conclusions
cannot be drawn because of steroid-independent effects of feed restriction on LH pulse frequency. In experiment 2, the effect
of dihydrotestosterone (DHT) in the VMH was determined. DHT administration to the VMH did not alter LH secretion in either
feed-restricted or fed wethers. Thus the VMH is one site wherein E negative feedback is enhanced during feed restriction in
the wether. In contrast, we found no evidence for enhanced responsiveness to androgen negative feedback within the VMH of
feed-restricted wethers. We suggest that increased sensitivity within the VMH to E, but not to DHT, is important for suppressing
LH secretion in undernourished male sheep.
Abstract
Increased sensitivity within the ventrolmedial hypothalamus to E, but not to DHT, is important for suppressing LH secretion
in undernourished male sheep</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diet</subject><subject>Dihydrotestosterone - administration & dosage</subject><subject>Dihydrotestosterone - pharmacology</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Drug Implants</subject><subject>Estradiol - administration & dosage</subject><subject>Estradiol - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone metabolism and regulation</subject><subject>Luteinizing Hormone - drug effects</subject><subject>Luteinizing Hormone - secretion</subject><subject>Male</subject><subject>Mammalian female genital system</subject><subject>Orchiectomy</subject><subject>Preoptic Area - drug effects</subject><subject>Preoptic Area - metabolism</subject><subject>Sheep</subject><subject>Sulpiride - pharmacology</subject><subject>Ventromedial Hypothalamic Nucleus - drug effects</subject><subject>Ventromedial Hypothalamic Nucleus - metabolism</subject><subject>Vertebrates: reproduction</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EokPhEUDewKpT_BPHzrJqp8xIIyHxK1aRk9xMjBJ7sB2Npo_IU3EpU3XJyr7yd46vziHkNWeXnFXqfePCGGEfQ4ezumSFEFo9IQuuRLXUojRPyYIxVi6lLOUZeZHST8Z4IYV8Ts64qrQwRi7I740fXOOyC56Gnm7nDM67O-d3dB3iFDzQz9BGuAeaI92G1o7uDjp61U1Iphztg3iFQ9iBv6DNnKkPmd644djFkCHlkDJEtLugm0RXfrC-RRPnaR6AfgOP0gk6Z0e6Pu5DHuxopznRmzn-3eUWEP6ENtG199-dhD_CjK_fAe_xJXnW2zHBq9N5Tr7err5cr5fbjx8211fb5SAZy0tluNJdL8qmaQvWQwOsrKTpiqqQWipheSF4W_UMhAUBVS-kAVmCNEJD0TN5Tt7988Xwf824Uz251MI4Wg9hTnVpSqa0-T_ItTTYToHgmxM4NxhCvY9usvFYP9SEwNsTYBPm30dMz6VHTnMsXPFHbnC74eAi1Gmy44i2sj4cDlrWRa0Nl38AOd210w</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>MCMANUS, Christina J</creator><creator>GOODMAN, Robert L</creator><creator>LLANZA, Nancy V</creator><creator>VALENT, Miroslav</creator><creator>DOBBINS, Adam B</creator><creator>CONNORS, John M</creator><creator>HILEMAN, Stanley M</creator><general>Society for the Study of Reproduction</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20051001</creationdate><title>Inhibition of Luteinizing Hormone Secretion by Localized Administration of Estrogen, but not Dihydrotestosterone, Is Enhanced in the Ventromedial Hypothalamus During Feed Restriction in the Young Wether</title><author>MCMANUS, Christina J ; GOODMAN, Robert L ; LLANZA, Nancy V ; VALENT, Miroslav ; DOBBINS, Adam B ; CONNORS, John M ; HILEMAN, Stanley M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h300t-58157df26bbc40febe06938d49437352a1421c9f0e2ae2e9f238e36e3827e4f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diet</topic><topic>Dihydrotestosterone - administration & dosage</topic><topic>Dihydrotestosterone - pharmacology</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Drug Implants</topic><topic>Estradiol - administration & dosage</topic><topic>Estradiol - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone metabolism and regulation</topic><topic>Luteinizing Hormone - drug effects</topic><topic>Luteinizing Hormone - secretion</topic><topic>Male</topic><topic>Mammalian female genital system</topic><topic>Orchiectomy</topic><topic>Preoptic Area - drug effects</topic><topic>Preoptic Area - metabolism</topic><topic>Sheep</topic><topic>Sulpiride - pharmacology</topic><topic>Ventromedial Hypothalamic Nucleus - drug effects</topic><topic>Ventromedial Hypothalamic Nucleus - metabolism</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MCMANUS, Christina J</creatorcontrib><creatorcontrib>GOODMAN, Robert L</creatorcontrib><creatorcontrib>LLANZA, Nancy V</creatorcontrib><creatorcontrib>VALENT, Miroslav</creatorcontrib><creatorcontrib>DOBBINS, Adam B</creatorcontrib><creatorcontrib>CONNORS, John M</creatorcontrib><creatorcontrib>HILEMAN, Stanley M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MCMANUS, Christina J</au><au>GOODMAN, Robert L</au><au>LLANZA, Nancy V</au><au>VALENT, Miroslav</au><au>DOBBINS, Adam B</au><au>CONNORS, John M</au><au>HILEMAN, Stanley M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Luteinizing Hormone Secretion by Localized Administration of Estrogen, but not Dihydrotestosterone, Is Enhanced in the Ventromedial Hypothalamus During Feed Restriction in the Young Wether</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>73</volume><issue>4</issue><spage>781</spage><epage>789</epage><pages>781-789</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>The ability of steroids to inhibit LH secretion is enhanced during undernutrition. To identify potential hypothalamic sites
at which this enhancement may occur, we examined LH secretion in feed-restricted or fed young wethers treated with locally
administered metabolites of testosterone. In experiment 1, microimplants containing crystalline estradiol-17β (E) or cholesterol
were administered via chronic guide tubes directed to the preoptic area (POA) or ventromedial hypothalamus (VMH) in fed or
feed-restricted wethers. E treatment in the VMH decreased LH pulse frequency, pulse amplitude, and mean LH concentration in
feed-restricted, but not fed, wethers. E may act in the POA to suppress LH under feed restriction, but definite conclusions
cannot be drawn because of steroid-independent effects of feed restriction on LH pulse frequency. In experiment 2, the effect
of dihydrotestosterone (DHT) in the VMH was determined. DHT administration to the VMH did not alter LH secretion in either
feed-restricted or fed wethers. Thus the VMH is one site wherein E negative feedback is enhanced during feed restriction in
the wether. In contrast, we found no evidence for enhanced responsiveness to androgen negative feedback within the VMH of
feed-restricted wethers. We suggest that increased sensitivity within the VMH to E, but not to DHT, is important for suppressing
LH secretion in undernourished male sheep.
Abstract
Increased sensitivity within the ventrolmedial hypothalamus to E, but not to DHT, is important for suppressing LH secretion
in undernourished male sheep</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>15972883</pmid><doi>10.1095/biolreprod.105.042275</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biology of reproduction, 2005-10, Vol.73 (4), p.781-789 |
| issn | 0006-3363 1529-7268 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; BioOne Complete |
| subjects | Animals Biological and medical sciences Diet Dihydrotestosterone - administration & dosage Dihydrotestosterone - pharmacology Dopamine Antagonists - pharmacology Drug Implants Estradiol - administration & dosage Estradiol - pharmacology Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Luteinizing Hormone - drug effects Luteinizing Hormone - secretion Male Mammalian female genital system Orchiectomy Preoptic Area - drug effects Preoptic Area - metabolism Sheep Sulpiride - pharmacology Ventromedial Hypothalamic Nucleus - drug effects Ventromedial Hypothalamic Nucleus - metabolism Vertebrates: reproduction |
| title | Inhibition of Luteinizing Hormone Secretion by Localized Administration of Estrogen, but not Dihydrotestosterone, Is Enhanced in the Ventromedial Hypothalamus During Feed Restriction in the Young Wether |
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