Occurrence of aminoglycoside-modifying-enzyme genes aac(6')-aph(2"), aph(3'), ant(4') and ant(6) in clinical isolates of Enterococcus faecalis resistant to high-level of gentamicin and amikacin
The genes coding for 4 aminoglycoside-modifying enzymes AAC(6')-APH(2"), APH(3'), ANT(4') and ANT(6) were determined in 44 Slovak clinical isolates of Enterococcus faecalis with high-level resistance to gentamicin (HLGR, collection 1) and 48 E. faecalis isolates with resistance t...
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| Veröffentlicht in: | Folia microbiologica 2006, Vol.51 (1), p.57-61 |
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| creator | Filipová, M Bujdákova, H Drahovská, H Lisková, A Hanzen, J |
| description | The genes coding for 4 aminoglycoside-modifying enzymes AAC(6')-APH(2"), APH(3'), ANT(4') and ANT(6) were determined in 44 Slovak clinical isolates of Enterococcus faecalis with high-level resistance to gentamicin (HLGR, collection 1) and 48 E. faecalis isolates with resistance to amikacin (AR, collection 2). The occurrence of spotted genes was (collection 1 vs. collection 2): aac(6)-aph(2") 81.8 vs. 8.3 %, ant(4') 52.3 vs. 81.3 %, aph(3') 50 vs. 56.3 % and ant(6) 6.8 vs. 4.2 %, the most frequent combinations of genes in the HLGR collection were aac(6')-aph(2") + ant(4') and aac(6')-aph(2") + aph(3). In contrast, the aph(3') + ant(4') gene profile was predominant in AR isolates. None of the isolates contained all four AGME genes simultaneously. |
| doi_str_mv | 10.1007/BF02931451 |
| format | Article |
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The occurrence of spotted genes was (collection 1 vs. collection 2): aac(6)-aph(2") 81.8 vs. 8.3 %, ant(4') 52.3 vs. 81.3 %, aph(3') 50 vs. 56.3 % and ant(6) 6.8 vs. 4.2 %, the most frequent combinations of genes in the HLGR collection were aac(6')-aph(2") + ant(4') and aac(6')-aph(2") + aph(3). In contrast, the aph(3') + ant(4') gene profile was predominant in AR isolates. 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The occurrence of spotted genes was (collection 1 vs. collection 2): aac(6)-aph(2") 81.8 vs. 8.3 %, ant(4') 52.3 vs. 81.3 %, aph(3') 50 vs. 56.3 % and ant(6) 6.8 vs. 4.2 %, the most frequent combinations of genes in the HLGR collection were aac(6')-aph(2") + ant(4') and aac(6')-aph(2") + aph(3). In contrast, the aph(3') + ant(4') gene profile was predominant in AR isolates. None of the isolates contained all four AGME genes simultaneously.</description><subject>Acetyltransferases - genetics</subject><subject>Amikacin - pharmacology</subject><subject>Aminoglycosides - pharmacology</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>DNA, Bacterial - analysis</subject><subject>DNA, Bacterial - genetics</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Enterococcus faecalis</subject><subject>Enterococcus faecalis - drug effects</subject><subject>Enterococcus faecalis - enzymology</subject><subject>Enterococcus faecalis - genetics</subject><subject>Enterococcus faecalis - isolation & purification</subject><subject>Gentamicins - pharmacology</subject><subject>Gram-Positive Bacterial Infections - microbiology</subject><subject>Humans</subject><subject>Microbial Sensitivity Tests</subject><subject>Nucleotidyltransferases - genetics</subject><subject>Phosphotransferases (Alcohol Group Acceptor) - genetics</subject><subject>Polymerase Chain Reaction</subject><issn>0015-5632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctOwzAQ9AHEo3DhA5DFgbYSAb_iJkeoykNC6gXOlWNvWoNjlzhFKn_Hn-GWckZ72Fnt7MxqF6EzSq4pIaObu3vCSk5FTvfQESE0z3LJ2SE6jvGNEEkEZwfokMqC0RHlR-h7qvWqbcFrwKHGqrE-zN1ah2gNZE0wtl5bP8_Af60bwHPwELFSeiD7w0wtFwN2MbzCG8D7G-C7gegPUzZbLIfYeqyd9VYrh20MTnVJIVlNfAdt0CH5R1wrSH0bcQvRxi6N4i7ghZ0vMgef4DYDybtL--kkuJVv7LtKxQnar5WLcLrLPfR6P3kZP2bP04en8e1ztmSCdJk2zGgtgdaVEDQvqYFS5qIo6kITanQ14mAoqSQTGpQshRxBVUvOCaRgwHvo8ld32YaPFcRu1tiowTnlIaziTBaS5FzQf4np8KWkpEjE8x1xVTVgZsvWNqpdz_6-w38AhuKPFg</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Filipová, M</creator><creator>Bujdákova, H</creator><creator>Drahovská, H</creator><creator>Lisková, A</creator><creator>Hanzen, J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Occurrence of aminoglycoside-modifying-enzyme genes aac(6')-aph(2"), aph(3'), ant(4') and ant(6) in clinical isolates of Enterococcus faecalis resistant to high-level of gentamicin and amikacin</title><author>Filipová, M ; Bujdákova, H ; Drahovská, H ; Lisková, A ; Hanzen, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p240t-cd2dcc6e1fb441591de965488f8c01dcb73ed10b624cea69467ebf6330e0e02e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acetyltransferases - genetics</topic><topic>Amikacin - pharmacology</topic><topic>Aminoglycosides - pharmacology</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>DNA, Bacterial - analysis</topic><topic>DNA, Bacterial - genetics</topic><topic>Drug Resistance, Multiple, Bacterial - genetics</topic><topic>Enterococcus faecalis</topic><topic>Enterococcus faecalis - drug effects</topic><topic>Enterococcus faecalis - enzymology</topic><topic>Enterococcus faecalis - genetics</topic><topic>Enterococcus faecalis - isolation & purification</topic><topic>Gentamicins - pharmacology</topic><topic>Gram-Positive Bacterial Infections - microbiology</topic><topic>Humans</topic><topic>Microbial Sensitivity Tests</topic><topic>Nucleotidyltransferases - genetics</topic><topic>Phosphotransferases (Alcohol Group Acceptor) - genetics</topic><topic>Polymerase Chain Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Filipová, M</creatorcontrib><creatorcontrib>Bujdákova, H</creatorcontrib><creatorcontrib>Drahovská, H</creatorcontrib><creatorcontrib>Lisková, A</creatorcontrib><creatorcontrib>Hanzen, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Folia microbiologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Filipová, M</au><au>Bujdákova, H</au><au>Drahovská, H</au><au>Lisková, A</au><au>Hanzen, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Occurrence of aminoglycoside-modifying-enzyme genes aac(6')-aph(2"), aph(3'), ant(4') and ant(6) in clinical isolates of Enterococcus faecalis resistant to high-level of gentamicin and amikacin</atitle><jtitle>Folia microbiologica</jtitle><addtitle>Folia Microbiol (Praha)</addtitle><date>2006</date><risdate>2006</risdate><volume>51</volume><issue>1</issue><spage>57</spage><epage>61</epage><pages>57-61</pages><issn>0015-5632</issn><abstract>The genes coding for 4 aminoglycoside-modifying enzymes AAC(6')-APH(2"), APH(3'), ANT(4') and ANT(6) were determined in 44 Slovak clinical isolates of Enterococcus faecalis with high-level resistance to gentamicin (HLGR, collection 1) and 48 E. faecalis isolates with resistance to amikacin (AR, collection 2). The occurrence of spotted genes was (collection 1 vs. collection 2): aac(6)-aph(2") 81.8 vs. 8.3 %, ant(4') 52.3 vs. 81.3 %, aph(3') 50 vs. 56.3 % and ant(6) 6.8 vs. 4.2 %, the most frequent combinations of genes in the HLGR collection were aac(6')-aph(2") + ant(4') and aac(6')-aph(2") + aph(3). In contrast, the aph(3') + ant(4') gene profile was predominant in AR isolates. None of the isolates contained all four AGME genes simultaneously.</abstract><cop>United States</cop><pmid>16821713</pmid><doi>10.1007/BF02931451</doi><tpages>5</tpages></addata></record> |
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| subjects | Acetyltransferases - genetics Amikacin - pharmacology Aminoglycosides - pharmacology Anti-Bacterial Agents - pharmacology DNA, Bacterial - analysis DNA, Bacterial - genetics Drug Resistance, Multiple, Bacterial - genetics Enterococcus faecalis Enterococcus faecalis - drug effects Enterococcus faecalis - enzymology Enterococcus faecalis - genetics Enterococcus faecalis - isolation & purification Gentamicins - pharmacology Gram-Positive Bacterial Infections - microbiology Humans Microbial Sensitivity Tests Nucleotidyltransferases - genetics Phosphotransferases (Alcohol Group Acceptor) - genetics Polymerase Chain Reaction |
| title | Occurrence of aminoglycoside-modifying-enzyme genes aac(6')-aph(2"), aph(3'), ant(4') and ant(6) in clinical isolates of Enterococcus faecalis resistant to high-level of gentamicin and amikacin |
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